Proprotein convertase
Proprotein convertase subtilisin/kexin type 9: A new target molecule for gene therapy
... 29. Chan, J.C., Piper, D.E., Cao, Q., Liu, D., King, C., Wang, W., Tang, J., Liu, Q., Higbee, J., Xia, Z., Di, Y., Shetterly, S., Arimura, Z., Salomonis, H., Romanow, W.G., Thibault, S.T., Zhang, R., Cao, P., Yang, X.P., ...
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Correlation between serum levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) and atherogenic lipoproteins in patients with coronary artery disease
... against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment with ...
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The Regulation of Proprotein Convertase Subtilisin/ Kexin Type 9 and Its Liver Involvement
... Introduction: Anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies have been very effective to lower low-density lipoprotein (LDL)-cholesterol. They attracted the attention on PCSK9 enzyme ...
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Small intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
... We have previously described the only reported case of human proprotein convertase 1 (PC1) deficiency, in a female (Subject A) with obesity, hypogonadism, hypoadrenalism, and reactive hypoglycemia. We now ...
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Hepatocellular carcinoma-associated hypercholesterolemia: involvement of proprotein-convertase-subtilisin-kexin type-9 (PCSK9)
... Proprotein-convertase-subtilisin-kexin type-9 (PCSK9) is a serine protease, primarily synthesized by the liver. Follow- ing the autocatalysis in endoplasmic reticulum, it is secreted as a catalytically ...
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Phylogenetic analysis of Amphioxus genes of the proprotein convertase family, including aPC6C, a marker of epithelial fusions during embryology
... As we have proposed above, aPC6C could be involved in epithelial fusions during embryology. In the same way, the mouse PC6 gene shows a prominent expression in the site of fusion of the two decidual lobes, a ...
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Development of proprotein convertase subtilisin/kexin type 9 inhibitors and the clinical potential of monoclonal antibodies in the management of lipid disorders
... Abstract: The aim of this manuscript is to review available data to evaluate the present status of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in the treatment of hypercho- ...
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Egyptian Association of Vascular Biology and Atherosclerosis (EAVA) consensus on the usage of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors
... The role of low-density lipoprotein cholesterol lowering in atherosclerotic cardiovascular disease prevention Among all lipid profile parameters, low-density lipopro- tein cholesterol (LDL-C) remains the primary analyte ...
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The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
... Proprotein convertase subtilisin-like kexin type 9 (PCSK9, OMIM 607786) is a newly discovered serine protease that plays a key role in LDL-C homeostasis by mediating LDL receptor (LDLR) breakdown through a ...
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The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis
... Proprotein convertase subtilisin/kexin type 9 (PCSK9), originally named neural apoptosis regulated convertase- 1 (NARC-1), is the ninth member of the proprotein con- vertase family ...
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Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates
... Proprotein convertase protein expression in epidermis and keratinocytes Antibodies to the catalytic domain and cytoplasmic domains of both furin and PC7/8 were used to further examine ex[r] ...
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The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells
... Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Success of current therapies is still limited and outcome is particularly poor for metastatic alveolar rhabdomyosarcoma (aRMS). We previously ...
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<p>Demographic And Clinical Characteristics Of Patients Prescribed Proprotein Convertase Subtilisin/kexin Type 9 Inhibitor Therapy And Patients Whose Current Lipid-Lowering Therapy Was Modified</p>
... The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor monoclonal antibodies represent an additional option for lowering of LDL-C levels in patients with ASCVD for whom maximally tolerated ...
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Proprotein convertase furin regulates osteocalcin and bone endocrine function
... and glucose tolerance. The cDNA sequence of OCN predicts that, like many other peptide hormones, OCN is first synthesized as a prohormone (pro-OCN). The importance of pro-OCN maturation in regulating OCN and the identity ...
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Myeloid cell expressed proprotein convertase FURIN attenuates inflammation
... pro-cytokine, which is converted into an active factor via a complex post-translational cascade involving a cleavage step catalyzed by FURIN [6, 54]. Further, undermined TGF-β1 signaling has been associated with an ...
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Efficacy and safety of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, alirocumab and evolocumab, a post-commercialization study
... Post-commercially, in 69 patients with heterozygous familial hypercholesterolemia (HeFH) and/or cardiovascular disease (CVD) with suboptimal LDL cholesterol (LDLC) lowering on maximal to[r] ...
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Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
... Finally, we show that PAR1 activation in the setting of high-tidal-volume ventilation causes an α v β 6-dependent increase in lung edema, whereas in Par1 –/– mice there is reduced [r] ...
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Structure and properties of proprotein convertase inhibitors
... Изучение действия указанных соедине ний на другие ПК показало, что синтезирован ные тетрапептиды действуют на РАСЕ4, РС5/6 и РС1/3 человека сходным образом (значения K i для соедине[r] ...
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The association of the PCSK9 rs562556 polymorphism with serum lipids level: a meta-analysis
... Proprotein convertase subtilisin/kexin type 9 (PCSK9), the ninth member of the subtilisin family of kexin-like proconvertases, was formerly known as neural apoptosis regulated convertase 1 (NARC-1) ...
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Serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with CAD risk and lipid profiles in southern Chinese Han population
... Proprotein convertase subtilisin/kexin type 9 (PCSK9), the ninth member of the proprotein convertase family, has been investigated extensively in the field of lipid me- tabolism ...
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