prostaglandin I2
Prostaglandin I2 is not a major metabolite of arachidonic acid in cultured endothelial cells from human foreskin microvessels
... Prostaglandin I2 (PGI2), a potent vasodilator and inhibitor of platelet aggregation, is a major product of arachidonic acid metabolism in endothelial cells that are derived from large blood vessels ...for ...
7
Beraprost Sodium, a Prostaglandin I2 Analogue, Protects Against Advanced Glycation End Products-induced Injury in Cultured Retinal Pericytes
... Beraprost sodium is a newly developed orally active prostaglandin I2 analogue with antiplatelet and vasodilating properties (1). Recently, beraprost sodium has been reported to exhibit beneficial effects on ...
5
Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta
... Platelets adhere to the subendothelial layer of newly deendothelialized arteries. Attachment can be reduced with exogenous prostacyclin (PGI2). Thus, the subendothelium may be unable to produce sufficient PGI2 to prevent ...
8
Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents
... The effects of neutrophil elastase on endothelial prostacyclin PGI2 production, nucleotide release, and responsiveness to vasoactive agents were compared with the effects of cathepsin G [r] ...
9
Effect of Prostaglandin I2 Analogs on Cytokine Expression in Human Myeloid Dendritic Cells via Epigenetic Regulation
... Prostaglandin I 2 (PGI 2 ) analog is regarded as a potential candidate for treating asthma. Human myeloid dendritic cells (mDCs) play a critical role in the pathogenesis of asthma. However, the effects of PGI 2 ...
12
Thrombogenic Effect of High Dose Aspirin in Rabbits: RELATIONSHIP TO INHIBITION OF VESSEL WALL SYNTHESIS OF PROSTAGLANDIN I2 LIKE ACTIVITY
... vessel wall using the thrombin-induced [ 14 C]serotonin release assay. A 200-mg/kg dose of aspirin significantly augmented thrombus size when compared to (a) sodium salicylate administered in equal doses, (b) aspirin in ...
5
Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells
... Statins inhibit 3-hydroxy-3-methylglutaryl (HMG-CoA) reductase, the rate limiting step in cholesterol synthesis. They are, therefore, used clinically to lower cholesterol and prevent atherosclerosis. Statins have ...
9
Cardiac and Renal Prostaglandin I2: BIOSYNTHESIS AND BIOLOGICAL EFFECTS IN ISOLATED PERFUSED RABBIT TISSUES
... prostaglandin (PG) I 2 . The evidence that supports this finding includes: (a) radiochemical identification of the stable end-product of PGI 2 , 6-keto-PGF 1a , in the venous effluent after arachidonic acid ...
12
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP
... PGI2 is produced by COX-2 and a selective inhibitor of this enzyme, SC-58125, also significantly reduced the increases in plasma renin activity and renin mRNA expression in WT mice with [r] ...
9
Variants in Human Prostacyclin Receptor Gene in Patients with Migraine Headache
... Objective: Prostaglandin I2 receptor plays a major physiologic role in the relaxation of arterial smooth muscle and vasodilation and possibly during migraine ...of Prostaglandin I2 receptor ...
5
<p>Prostaglandins as the Agents That Modulate the Course of Brain Disorders</p>
... Abstract: Neurologic and neuropsychiatric diseases are associated with great morbidity and mortality. Prostaglandins (PGs) are formed by sequential oxygenation of arachidonic acid in physiologic and pathologic ...
13
Rough I2-Lacunary Statistical Convergence of Double Sequences
... Abstract: In this paper, we introduce and study the notion of rough I 2 -lacunary statistical convergence of double sequences in normed linear spaces1. We also introduce the[r] ...
14
Mapping the predictors of single word recognition:a research synthesis
... • I2 reflects how much variation would remain if sampling error was removed Borenstein, 2017 • Points at 0 are interaction effect I2 values • Greater proportion of effect sizes are in th[r] ...
51
Volume 2, Issue 7, July 2013 Page 136
... The problem with this approach is that the section modulus EI for the beam must remain constant. The upper support collar introduces a change in I for the system, thus violating this requirement. The decision was made to ...
6
Impacts of Cytosolic Phospholipase A2, 15 Prostaglandin Dehydrogenase, and Cyclooxygenase 2 Expressions on Tumor Progression in Colorectal Cancer
... Purpose: In addition to cyclooxygenase-2 COX-2 which is related to prostaglandin E2 synthesis, other enzymes such as cytosolic phospholipase A2 cPLA2, microsomal prostaglandin E2 synthas[r] ...
8
Induction of Murine Mucosal CCR5-Reactive Antibodies as an Anti-Human Immunodeficiency Virus Strategy
... Cloning and expression of a chimeric FHV-CCR5 immunogen. The FHV Epitope Presenting System (6, 7, 32, 35), based on a modified capsid precursor protein of the Flock House virus (FHV), was obtained through the courtesy of ...
11
Clinical Decision Making of Nurses Regarding Elder Abuse
... phosphate buffer perchloric acid pars distalis of the pituitary gland 3’5’cyclic AMP phosphodiesterase pars distalis removal pelvic ganglia prostaglandins prostaglandin E2 prostaglandin [r] ...
120
[Phthalocyaninato(2–)]arsenic(III) triiodide
... than the central iodine (I1). This interaction correlates well with the charge on the I atoms (ÿ0.419 on both terminal I atoms and ÿ0.163 on the central I atom) calculated by Landrum et al. (1997). The As I3 (terminal) ...
11
Airway response to acute mechanical stress in a human bronchial model of stretch
... Effect of stretch 5 minutes, 2.5 × basal tone on the production of leukotriene E4 LTE4, prostaglandin screening PG, and prostaglandin E2 PGE2 in an organ bath assessed by ELISA during th[r] ...
11
95% CI=1.03 1.79, I2=0%, fixed model) and renal carcinoma (OR=4.86, 95% CI=2.72 8.67, I2=0%, fixed model).
... Abstract: Background: The prognostic value of CD117 expression in cancers has been evaluated for several years while the results remain controversial. We thus performed a systematic review and meta-analysis of studies ...
10