prostaglandin/s
Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine derived human interleukin 1 and inhibitor(s)
... Interleukin 1 (IL-1) possesses multiple biological activities that may be blocked selectively by different inhibitors. Some known inhibitors block the lymphocyte activating factor (LAF/IL- 1) but not the mononuclear cell ...
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Interleukin 1 stimulates its own receptor expression on human fibroblasts through the endogenous production of prostaglandin(s)
... forskolin increased the specific binding of 125I-IL 1 alpha to fibroblasts. Scatchard analysis indicated that PGE2 increased the number of IL 1R from approximately 1.6 X 10(3) to 5.4 X 10(3) per cell without change in ...
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<p>Prostaglandins as the Agents That Modulate the Course of Brain Disorders</p>
... sing prostaglandin ’ s action on neuronal metabolism is asso- ciated with less neuronal injury and lower secretion of proin fl ammatory cytokines, TNF α , and ...’ s disease is mainly mediated through ...
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Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation
... on prostate cancer cells, to investiagte whether it has an effect on radiation resistance, we performed the clonogenic assay. Both Control and AKR1C3-over cells were pretreated with a series concentration of PGF2α after ...
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Effect of prostaglandin E2 injection on the structural properties of the rat patellar tendon
... In support of PGE2 ’ s positive role in stimulating tendon remodeling, recent studies have shown that inhibitors of prostaglandin pro- duction, cyclooxgenase (COX) inhibitors, can impair[r] ...
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Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta
... Platelets adhere to the subendothelial layer of newly deendothelialized arteries. Attachment can be reduced with exogenous prostacyclin (PGI2). Thus, the subendothelium may be unable to produce sufficient PGI2 to prevent ...
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Suppression of immune complex vasculitis in rats by prostaglandin
... Immune complex-induced vascular damage can be markedly suppressed by treatment of rats with either prostaglandin (PG)E1 or its stable derivative, 15-(S)-15-methyl PGE1, but not with PGF2 alpha. In addition, ...
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Effect of ACTH and CRH on Plasma Levels of Cortisol and Prostaglandin F2α Metabolite in Cycling Gilts and Castrated Boars
... Madej A, Mwanza AM, Kindahl H, Einarsson S: Effect of ACTH and CRH on plasma levels of cortisol and prostaglandin F 2αα metabolite in cycling gilts and cas- trated boars. Acta vet. scand. 2005, 46, 249-256. ...
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Epac1 links prostaglandin E
... PGE 2 exerts its effects through activation of E-type prostanoid receptors. A549 cells mainly express the EP 2 and EP 4 receptor subtype which are Gα s -coupled and enhance formation of intracellular cyclic AMP. ...
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Adenovirus Triggers Reorganization of Vimentin-Containing Intermediate Filaments Resulting in the Perinuclear Movement of cPLA2 and Suppression of Prostaglandin Production
... Construction of the mutant adenovirus dl309 and dl758 has been described previously (26, 27). The mutant dl309 was derived from Ad5 and lacks the 10.4K, 14.5K and 14.7K genes of the E3 transcription unit. The mutant ...
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Characterization of the Platelet Prostaglandin D2 Receptor: LOSS OF PROSTAGLANDIN D2 RECEPTORS IN PLATELETS OF PATIENTS WITH MYELOPROLIFERATIVE DISORDERS
... This PGD2 receptor assay was then used to study platelets from five patients with myeloproliferative disorders polycythemia vera, essential thrombocythemia, and chronic myelogenous leuke[r] ...
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Identification of prostaglandin receptors in human ureters
... of prostaglandin receptor expression profiles in obstructed human ureters plays an important role in the attempt to implement new therapy strategies with better ef- ficiency and reduced side effects in comparison ...
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Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
... b Number of principal components that explain ≥80% of the variance in polyp risk c Likelihood ratio test comparing a model with principle components + age and sex to a model containi[r] ...
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Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
... significant association for a tagSNP in EP2 and in EP4, but no other associations between tagSNPs in PGES or PGDH and risk of colorectal adenomas. Further, we observed several statistically significant or marginally ...
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Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches
... Molecular mechanisms underlying bipolar affective disorders are unknown. Difficulties arise from genetic and phenotypic heterogeneity of patients and the lack of animal models. Thus, we focused on only one patient (n = ...
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Prostaglandin D 2strengthens human endothelial
... barrier disruption in primary human pulmonary and dermal microvascular endothelial cells as well 85.. as in pulmonary artery endothelial cells by activating EP4 and only to a small exte[r] ...
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APPROACHES TO OVERCOME NSAID INDUCED ULCERATION IN ARTHRITIC PAIN MANAGEMENT: PERSPECTIVES AND PROSPECTS
... Rheumatoid arthritis is an auto-immune joint disorder involving pain and inflammation. Various approaches are used for pain management and relief from arthritis with single and multiple dose therapy. In single dose ...
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Studies on the Anti-Inflammatory, Analgesic and Antipyretic Properties of Pavonia Zeylanica
... to prostaglandin synthesis inhibition, as described for the anti-inflammatory mechanism of non- steroidal anti-inflammatory drugs in the inhibition of inflammatory process induced by ...
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Effect of prostaglandin analogs on matrix metalloproteinases and tissue inhibitor of metalloproteinases in eyelid muscle specimens
... Purpose: To characterize the effect of prostaglandin analogs (PAs) on tissue specific expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinas[r] ...
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Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases
... Fig. 1 Quantitative PCR shows gene expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in human non-pigmented ciliary epithelial cells (HNPCECs). MMP-1, MMP-2, MMP-3, MMP-9, ...
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