Prostate Specific Membrane Antigen (PSMA)
Alterations in androgen deprivation enhanced prostate-specific membrane antigen (PSMA) expression in prostate cancer cells as a target for diagnostics and therapy
... cently, prostate-specific membrane antigen (PSMA) has been introduced as an indicator of androgen re- ceptor signalling in PCa by PET imaging ...
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Histopathological Analysis and Study of Expression of Prostate Specific Membrane Antigen (PSMA) in Thyroid Follicular Neoplasms
... Prostate Specific Membrane Antigen (PSMA) is an integral membrane protein, anchored to the epithelial cells which were used to detect prostatic ...for prostate imaging yielded a ...
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Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases
... transmembrane prostate specific membrane antigen (PSMA) is robustly expressed by the tumor vascular endothelium in a variety of solid cancers, including GBM and primary adenocarcinoma of the ...
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Co-expression and impact of prostate specific membrane antigen and prostate specific antigen in prostatic pathologies
... normal prostate glandular architecture including benign prostatic hyperplasia and prostate cancer and its associated ...Aberrant prostate epithelial cells growth may result in direct production of ...
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Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent
... Prostate-specific membrane antigen (PSMA) is a well-established target for nuclear imaging and therapy of prostate cancer (PCa). Radiolabeled small-molecule PSMA inhibitors are ...
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Biodistribution and radiation dosimetry of [18F]-JK-PSMA-7 as a novel prostate-specific membrane antigen-specific ligand for PET/CT imaging of prostate cancer
... A decisive breakthrough was achieved with low-molecu- lar ligands that bind to the active center of the extracellu- lar domain of prostate-specific membrane antigen [2, 3]. It is therefore not ...
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Targeting of prostate specific membrane antigen for radio ligand therapy of triple negative breast cancer
... of prostate-specific membrane antigen (PSMA) addressing small molecules initiated applica- tion of their radiolabeled derivatives for theranostics of prostate cancer (PrCa) ...in ...
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A Modular Strategy to Prepare Multivalent Inhibitors of Prostate- Specific Membrane Antigen (PSMA)
... integral membrane protein prostate-specific membrane antigen (PSMA) is becoming increasingly recognized as a viable target for imaging and therapy of prostate and other forms of ...
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Anti-tumor effects of a recombinant anti-prostate specific membrane antigen immunotoxin against prostate cancer cells
... anti-prostate-specific membrane antigen (PSMA) antibody (J591), the furin cleavage sequences of diphtheria toxin (Fdt), and the reverse coding sequences of the large and small subunits of ...
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Engineered Jurkat Cells for Targeting Prostate-Specific Membrane Antigen on Prostate Cancer Cells by Nanobody-Based Chimeric Antigen Receptor
... a specific antigen-binding fragment derived from camelid that has great homology to human VH and low immunogenic ...with prostate cancer cells and analyzed for IL-2 secretion, CD25 expression, and ...
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A dimerized urea-based inhibitor of the prostate-specific membrane antigen for 68Ga-PET imaging of prostate cancer
... It has been previously reported that dimeric peptides such as cyclic arginine-glycine-aspartic acid (RGD) exhibit significant higher tumor uptake and prolonged retention as compared to their corresponding monomeric ...
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PSMA PET for primary lymph node staging of intermediate and high-risk prostate cancer: an expedited systematic review
... (prostate specific membrane antigen OR psma) AND (prostate malignancy OR prostatic carcin- oma OR prostate cancer OR prostatic ...‘prostate specific membrane ...
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Prostate-specific membrane antigen: evidence for the existence of a second related human gene
... Chromosome sublocalisation PCR analysis of a number of cell lines containing fragments of human chromosome 11 was next performed.. The human component of these various cell lines is illu[r] ...
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PubMedCentral-PMC5464417.pdf
... Prostate-specific membrane antigen (PSMA) is an attractive therapeutic target for castration- resistant prostate cancer (CRPC). PSMA is a transmembrane protein expressed on virtually ...
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Quantitative [Fe]MRI of PSMA-targeted SPIONs specifically discriminates among prostate tumor cell types based on their PSMA expression levels
... human prostate tumor ...anti-prostate specific membrane antigen (PSMA) conjugated SPIONs to PSMA-positive LNCaP and PSMA-negative DU145 cells in vitro allowed a facile discrimination ...
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Promise of BLCA38 as a Targeting Antibody for Tissue-Specific Gene Delivery to Prostate Cancer
... showed membrane binding on DU145 (97%), Pc3 (92%) and to a lesser extent, on LN3 cells (82% of cells) by flow cytometry (Figure 1A); both membrane and cytoplasmic staining were seen in these cells grown as ...
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Microtubule inhibitor-based antibody–drug conjugates for cancer therapy
... expressed antigen is PSMA. In contrast to prostate-specific antigen, which is a secreted protein, PSMA is an integral cell-surface membrane ...normal prostate epithelium is not ...
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Prostate specific antigen density values among patients with symptomatic prostatic enlargement in Nigeria
... mean prostate volume was not statistically different between the two ...the prostate; rather, the distortion in the basement membrane could be the likely ...mean prostate vol- ume in our study ...
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Study of Correlation between Prostate Specific Antigen and Matrix Metalloproteinase-2 Activity in Benign and Malignant Prostate Hyperplasia
... rostate cancer (PC) is the second most common cause of cancer death in men in the world. The most threatening and primary cause of death from PC is invasion and metastasis. One of the first events in progression to ...
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Role of Prostate Specific Antigen (PSA) in Pathogenesis of Prostate Cancer
... found prostate-specific antigen might promote pros- tate cancer proliferation via functioning as a coactivator to enhance ARA70-induced androgen receptor transacti- vation without involving its ...
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