protein c
The Role of Protein C, Protein S, and Resistance to Activated Protein C in Legg-Perthes Disease
... ing for protein C, protein S, or APC-R, and transport to regional centers requires careful packaging and handling. This study showed that age-based normal values are critical to identifying ...
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The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness
... of Protein S, however, TNF-α levels remained similar to those seen in animals administered a sublethal dose of ...vated Protein C pathway can control the inflammatory ...
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Assessment of Protein C and Protein S of Pregnancy Loss Victims
... The microtitre plate provided in this kit has been pre-coated with antibody. Standard, samples and HRP conjugated antibody were added to wells according to the manufacturer, Melsin Laboratories, China. After incubation ...
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Detection of protein C activation in humans
... from protein C when this zymogen is activated by thrombin bound to thrombomodulin present on the vascular ...The protein C activation peptide (PCP) was synthesized using the solid-phase method ...
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Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states
... Changes in the Mean Ratio of Protein C Anticoagulant Activity to Protein C Antigen, Protein C Amidolytic Activity, Factor VII Activity, and Factor X Activity in Patients Starting Oral An[r] ...
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Activated protein C resistance in Behcet’s disease
... Behcet ’ s disease is a chronic multi-system disorder of unknown etiology with protean manifestations. Venous thromboembolism is more common than arterial thrombosis, with deep vein thrombosis being the most frequent. ...
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Deficiency of protein C in congenital thrombotic disease
... of protein C antigen, whereas unaffected family members had normal ...activated protein C is a potent in vitro anticoagulant enzyme and an in vivo profibrinolytic agent, it is suggested that ...
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Dissociation of activated protein C functions by elimination of protein S cofactor enhancement
... Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin ...cell protein C receptor can ...
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The protein C pathway : linking inflammation and coagulation
... to hospital. The amputation rate for patients treated with PC within 24 hours o f admission to hospital o f 2/31 (6.5%). These two cases demonstrate that early PC replacement may fail to prevent the morbidity associated ...
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Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency
... Abstract: Protein C is one of the major inhibitors of the coagulation system that downregulate thrombin ...congenital protein C deficiency leads to a hypercoagulability state that usually ...
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Long-term Subcutaneous Protein C Replacement in Neonatal Severe Protein C Deficiency
... administered protein C concentrate may be a good therapeutic tool for the long-term treatment of severe protein C ...studies, protein C activity levels can be much lower than ...
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Impaired secretion of the elongated mutant of protein C (protein C Nagoya) Molecular and cellular basis for hereditary protein C deficiency
... to protein C deficiency, an expression plasmid containing this mutation was transfected into COS 7, BHK, and psi-2 cells, and the secretory process of the expressed Protein C-Nagoya was ...
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Activation of Protein C In Vivo
... An endothelial cell-associated cofactor that greatly enhances the rate of protein C activation by thrombin has recently been described. The observation that the cofactor binds thrombin with unusually high ...
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Severe Acquired Protein C Deficiency in Purpura Fulminans Associated With Disseminated Intravascular Coagulation: Treatment With Protein C Concentrate
... usually seen in three clinical settings: (1) in the new- born period as a manifestation of homozygous pro- tein C deficiency, or rarely protein S deficiency13’14; (2) in individuals with[r] ...
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Inhibition of activated protein C by platelets
... Platelet releasate obtained by stimulation of platelets with thrombin and epinephrine contained an inhibitor that interfered with the ability of phospholipid and washed platelet membrane[r] ...
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Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect
... surfactant protein-B (SP-B) [2,3] and ABCA3, which encodes ATP-binding cassette transporter A3 (ABCA3) typically present as lethal respiratory distress syndrome in neonates ...surfactant protein-C ...
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The Leiden Thrombophilia Study (LETS)
... In this way the role of a deficiency of protein C, protein S or antithrombin and of APC (activated protein C) resistance, elevated von Willebrand factor and factor VIII:c levels, hyperho[r] ...
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Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions
... binding protein (OSBP), which is recruited to the MW along with PI4K (48), and is reported to regulate cholesterol transport to the ...NS5A-host protein interactions, we believe that this study makes a ...
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Bararia, Deepak (2007): Proteomic Identification of the MYST Domain Histone Acetyltransferase TIP60 as a Coactivator of the Myeloid Transcription Factor C/EBPα. Dissertation, LMU München: Medizinische Fakultät
... enhances C/EBPa ...with C/EBPa. (h) Anisomycin-induced JNK activation prolongs C/EBPa half-life; HL60 cells were labelled with methionine and chased with cold methionine for 0–6 h with or without ...
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Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
... AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly ...and protein kinase B (Akt) in cultured human endothelial ...of protein ...
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