Protein C deficiency
Simultaneous Left Ventricular and Deep Vein Thrombi Caused by Protein C Deficiency
... both protein C and protein S ...tomography. Protein C deficiency should be considered as the cause of simulta- neous LV thrombosis and deep vein thrombosis, especially in ...
5
Impaired secretion of the elongated mutant of protein C (protein C Nagoya) Molecular and cellular basis for hereditary protein C deficiency
... to protein C deficiency, an expression plasmid containing this mutation was transfected into COS 7, BHK, and psi-2 cells, and the secretory process of the expressed Protein C-Nagoya was ...
9
Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect
... The relevance of heterozygosity for hereditary protein C deficiency äs a risk factor for venous thrombosis has been disputed because heterozygotes without Symptoms have been identified a[r] ...
5
Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study)
... This population-based, case-control study confirms that, among unselected patients, the prevalence of a (hereditary) protein C deficiency and of lowered protein S and antithrom- bin plas[r] ...
7
Long-term Subcutaneous Protein C Replacement in Neonatal Severe Protein C Deficiency
... administer protein C concentrate every day to pre- vent significant fluctuations in trough levels of protein C concentrate and to minimize the effect of forgetting 1 dos- age on trough ...
7
Genotypic and phenotypic character of Chinese neonates with congenital protein C deficiency: a case report and literature review
... PC deficiency was first described in 1962 as a suspected inherited lesion identified in three siblings with similar skin lesions ...glyco- protein synthesized by the liver as a proenzyme for PC ...PC ...
7
Homozygous Protein C Deficiency: Observations on the Nature of the Molecular Abnormality and the Effectiveness of Warfarin Therapy
... tein C deficiency, warfarin, vitamin K-dependent fac-.. tors, hypercoagulability, disseminated intravascular coagulation.[r] ...
7
Attitudes toward genetic testing for thrombophilia in asymptomatic members of a large family with heritable protein C deficiency
... family screening of individuals with a close relative with thrombophilia can help optimize prophylactic treatment of asymptomatic carriers in high-risk situations (i.e. during surgery or pregnancy in which they would ...
8
Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice
... FVII deficiency is a rare autosomal recessive disease, affecting approximately 1 in 500,000 individuals (7), that is caused by a variety of known mutations that decrease FVII antigen or catalytic ...FVII/PC ...
8
Severe Acquired Protein C Deficiency in Purpura Fulminans Associated With Disseminated Intravascular Coagulation: Treatment With Protein C Concentrate
... usually seen in three clinical settings: (1) in the new- born period as a manifestation of homozygous pro- tein C deficiency, or rarely protein S deficiency13’14; (2) in individuals with[r] ...
7
Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency
... 6 to 12 hours (next to heparin, cryoprecipitate, tissue plas- minogen activator and others), followed by substitution of human PC concentrate, as soon as diagnosis of severe PC deficiency was made and/or the ...
10
Purpura Fulminans in a Chinese Boy With Congenital Protein C Deficiency
... Although one cannot totally exclude the possibility that these extremely low values might have been caused by a consumptive process of coagulation factors during attacks or coumarin-indu[r] ...
9
CASE PRESENTATION
... of protein C, protein S, and antithrombin are reduced in the setting of acute ...normal protein C activity in this setting essentially rules out hereditary protein C ...
11
CASE REPORT: NEONATAL THROMBOSIS
... of protein C, protein S, and antithrombin are reduced in the setting of acute ...normal protein C activity in this setting essentially rules out hereditary protein C ...
5
Lipoprotein (a): Its Role in Childhood Thromboembolism
... showed protein C deficiency, 2 showed antithrombin deficiency, and 4 showed primary antiphospholipid ...additional protein C ...
5
Severe Protein S Deficiency in a Newborn
... Its therapy is similar to that for protein C deficiency with thrombotic episodes controlled by administration of plasma products containing the. missing protein[r] ...
5
Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities
... We derived the cosmid vector, pNDcosI, from superCosI (Stratagene) by modifying the multiple cloning site to contain unique NotI and SacII sites. The transgene cosmid vector was assembled in 4-way ligation of: (a) a ...
11
Deficiency of protein C in congenital thrombotic disease
... of protein C antigen, whereas unaffected family members had normal ...familial deficiency of antithrombin III and plasminogen. Because activated protein C is a potent in vitro ...
5
Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection
... tissue from epidermis to muscle that characterized by extensive and rapidly spreading necrosis. Molecular stud- ies [27] suggested that the injured muscle cells promote the adhesion of S. pyogenes that deteriorate local ...
6
Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study
... The study was approved by ethical committees in Kenya and the Netherlands. We conducted a survey (June 2010) at 15 primary schools in Kibwezi and Makindu Districts in Eastern Province, Kenya, which had been selected from ...
9