Protein disulfide
A Prediction Method of Protein Disulfide Bond Based on Hybrid Strategy
... of protein disulfide bond based on support vector machine and sample selection is proposed in this ...the protein sequences selected are encoded according to a certain encoding, input data for the ...
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Expression of protein disulfide isomerase A3 precursor in colorectal cancer
... Figure 5 Effect of protein disulfide isomerase A3 precursor (PDIA3) knockdown on apoptosis. (A) SW480 cells were treated with small interfering RNA (siRNA)-PDIA3, and then the cells were stained with TUNEL ...
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Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents
... Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein disulfide isomerase (PDI) ...
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The C terminal CGHC motif of protein disulfide isomerase supports thrombosis
... Protein disulfide isomerase (PDI) is the prototypic member of the PDI family of enzymes that catalyze the reversible formation and isomerization of disulfide bonds ...
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Blastomyces Virulence Adhesin 1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase
... (BAD-1) protein mediates the virulence of the yeast Blastomyces dermatitidis, in part by bind- ing host lung tissue, the extracellular matrix, and cellular receptors via glycosaminoglycans (GAGs), such as heparan ...
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Identification and characterization of the protein disulfide isomerase multigene family in plants.
... the Protein Disulfide Isomerase Multigene Family in ...Boston). Protein disulfide isomerases (PDIs) contain thioredoxin domains and aid in the formation of proper disulfide bonds during ...
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Lemon protein disulfide isomerase: cDNA cloning and biochemical characterization
... Protein disulfide isomerase (PDI), a member of thioredoxin- superfamily, plays a key role in catalyzing disulfide bond for- mation, reduction, and ...reported protein folding enzyme ...
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The interaction of protein disulfide isomerase with a substrate protein at different stages along its folding pathway
... If disulfide bond formation is required, both chaperones can associate with the PDI family protein ERp57, via an extended domain known as the P domain (Solda, Garbi et ...A protein can only exit the ...
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Protein disulfide isomerase interacts with a substrate protein at all stages along its folding pathway
... Previous work identified residues within the b’ domain of PDI that form the binding site for peptides and unfolded proteins [26,33–35], but no study has been done with a partly-folded intermediate on an oxidative ...
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Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection
... ABSTRACT Diverse intracellular pathogens rely on eukaryotic cell surface disulfide reductases to invade host cells. Pharmacologic inhibition of these enzymes is cyto- toxic, making it impractical for treatment. ...
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A PDI Family Network Acts Distinctly and Coordinately with ERp29 To Facilitate Polyomavirus Infection
... a protein disulfide isomerase (PDI) member, extrudes the Py VP1 C-terminal arm to initiate ER membrane ...Py’s disulfide bonds in vitro, only ERp57 and PDI operate in concert with ERp29 to unfold the ...
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Selenocystamine improves protein accumulation in chloroplasts of eukaryotic green algae
... and protein disulfide isomerases that facilitate these complex proteins folding and assembly, little has been done to determine which processes serve as rate‑ limiting steps for protein ...
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Disulfide-Based Diblock Copolymer Worm Gels: A Wholly-Synthetic Thermoreversible 3D Matrix for Sheet-Based Cultures
... Conventional cell culture methods require proteases (e.g., trypsin, Accumax, Accutase etc.) to release cells from 2D surfaces or to recover cells from protein based gels. 35 In contrast, cells cultured within ...
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Engineered Intermonomeric Disulfide Bonds in the Globular Domain of Newcastle Disease Virus Hemagglutinin-Neuraminidase Protein: Implications for the Mechanism of Fusion Promotion
... intermonomeric disulfide bond on the func- tions of the mutated protein relative to those of wt hPIV3 HN was ...The disulfide-linked protein is efficiently ex- pressed at the cell surface, as ...
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Development of Interest in Science and Interest in Teaching Elementary Science: Influence of Informal, School, and Inquiry Methods Course Experiences
... The protein structure was embedded in a fine three dimensional grid of points with a spacing 0.5˚ A. Each potential calcium binding site was defined a grid point located not within the van der Waals radius of a ...
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Disulfide Bonds and Membrane Topology of the Vaccinia Virus A17L Envelope Protein
... A17L protein is the best character- ized. Disulfide-linked A17L protein dimers have been reported to form a complex with dimers of the A14L protein (16) and trimers of the A27L protein ...
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Protein-protein interactions within paramyxoviruses identified by native disulfide bonding or reversible chemical cross-linking.
... Homooligomers of the glycoprotein F, the matrix protein M, and the major nucleocapsid protein NP were produced in both Sendai and Newcastle disease viruses after mild cross-linking of al[r] ...
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Addition of high-mannose sugars must precede disulfide bond formation for proper folding of Sendai virus glycoproteins.
... If correct disulfides are essential for the formation of native protein structures, we would predict that i the reduction of disulfide bonds would abolish the native immunoreactivities, [r] ...
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Autophagy is dispensable to overcome ER stress in the filamentous fungus Aspergillus niger
... serine/threonine protein kinase Atg1 forms a part of the regulatory Atg1 kinase complex in yeast which initiates the autophagic process, while Atg8 is a structural component of autophagic vesicle membranes (Cheong ...
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Engineering of therapeutic proteins production in Escherichia coli
... therapeutic protein has to be increased to compensate for the lost activity but also because subsequent aggregation may cause immunogenicity ...a protein may be marketed under different brand names and the ...
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