protein glycosylation
Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma
... of protein glycosylation-based therapies for ...how protein glycosylation and associated glycosyltransferases affect cellular behaviors and treatment outcome of various cancers, especially ...
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Golgb1 regulates protein glycosylation and is crucial for mammalian palate development
... transmembrane protein (Linstedt and Hauri, ...transcytosis-associated protein p115 (also known as Uso1), a cytosolic protein involved in tethering endoplasmic reticulum (ER)-derived vesicles to the ...
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Evolutional and clinical implications of the epigenetic regulation of protein glycosylation
... Since glycosylation is a very complex metabolic process including hundreds of factors encoded by a large group of “glycogenes” (Nairn et ...in protein glycosylation is still limited, but their ...
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Aberrant protein glycosylation in the carbohydrate-deficient glycoprotein syndromes and galactosaemia
... Powell et al. (1994) took an alternative approach and demonstrated that there was indeed a defect in the synthesis of the LLO. They showed that when CDGS type 1 fibroblasts were labelled with a 60 minute pulse o f ...
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Modification of the Hepatitis B Virus Envelope Protein Glycosylation Pattern Interferes with Secretion of Viral Particles, Infectivity, and Susceptibility to Neutralizing Antibodies
... 101 to 117, 125 to 136, and 143 to 145 that we previously docu- mented to be nonessential to the AGL infectivity determinant (8). Within these regions, the 113-SSTTST-118 sequence appears to be the best suited for the ...
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Detection of protein glycosylation using tip enhanced Raman scattering
... correct glycosylation of just a few protein molecules at a time using this powerful high spatial resolution ...of protein samples can be very complex, carefully considered data processing steps can ...
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Effect of brefeldin A on alphaherpesvirus membrane protein glycosylation and virus egress.
... Monensin inhibits the processing of herpes simplex virus glycoproteins, their transport to the cell surface, and the egress of virions from infected cells.. Role of cytoplasmic vacuoles [r] ...
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Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism
... ation could provide a basis for differential strain susceptibility (2, 32, 35). The structural differences between strains are quite substantial, as judged by the strain-specific fluorescence pat- tern of luminescent ...
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Protein-linked glycans in periodontal bacteria : prevalence and role at the immune interface
... of protein glycosylation in periodontal pathogenic bacteria and its role in the modulation of the host immune ...surface-layer protein glycosylation system of the periodontal pathogen ...
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Fear vs Hope: Do Discrete Emotions Mediate Message Frame Effectiveness In Genetic Cancer Screening Appeals
... vitro protein glycosylation because it is a nine-subunit enzyme and is ...for protein N-glycosylation in Campylobacter jejuni, which can be used as a tool for glycoprotein glycosylation ...
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Evidence for glycosylation on a DNA-binding protein of Salmonella enterica
... this protein [34]. In fact, self-aggregation of this protein leads to the formation of oligomers of variable size, which tend to ...nuclear protein glycosylation can be very labile, and J-Dps ...
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Mass spectrometry-based N-glycoproteomics for cancer biomarker discovery
... in glycosylation at a site-specific ...of protein and the site-specific glycosylation profile, which is useful to determine if altered glycosylation profiles in serum/plasma were due to a ...
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Role of N-Linked Glycans on Bunyamwera Virus Glycoproteins in Intracellular Trafficking, Protein Folding, and Virus Infectivity
... N-linked glycosylation is to promoter proper protein folding of glycoproteins (20, 21, ...Gn protein, which is nearest to the N terminus of the BUN glycoprotein precursor, is crucial for achieving ...
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The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM
... 3 Recently, we described the presence of highly sialylated N-linked glycans in the antigen- binding fragment (Fab) of almost all anti-citrullinated protein antibody (ACPA) IgG molecules [1, 2]. These glycans could ...
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Expression of Gp63 Gene from NIH Strain of Leishmania major in Pichia pastoris
... and glycosylation aspects of the expressed protein, gp63 gene from NIH strain of ...recombinant protein was confirmed by Western blotting and electron ...
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Cell- and Protein-Directed Glycosylation of Native Cleaved HIV-1 Envelope
... Env glycosylation includes a dominant popu- lation of oligomannose-type glycans with a population of com- plex-type glycans that are predominantly highly processed bi-, tri-, and tetra-antennary sialylated ...the ...
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Detection of glycosylation and iron binding protein modifications using Raman spectroscopy
... glycosylated, specifically with mannose, to maintain protein stability and immunogenicity. 1-3 Figures 3A and 3B display the averaged Raman spectra of glycosylated and non-glycosylated transferrin, with and ...
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The clinical relevance of glycobiology
... The study of protein-bound glycans dates back to the 19th century (1). Until recently these macromolecules have played second fiddle to their cousins, the nucleic acids and pro- teins. This is not surprising in ...
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Braunger, Katharina Isabelle (2018): Cryo-EM analysis of mammalian co-translational membrane protein insertion and N-linked glycosylation. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... lumen (Wiedmann et al., 1987; Görlich et al., 1990). More recently it has also been indicated to be involved in topology determination of membrane proteins (Som- mer et al., 2013). Moreover, mutations in the ...
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The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes
... Advanced glycosylation end products receptor; AXL: AXL Receptor Tyrosine Kinase; CCL13: Monocyte chemotactic protein 4; CCL2: Monocyte chemotactic protein 1; CCL20: Macrophage inflammatory ...
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