Proton channel
Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest
... FIG 3 Proton channel activity of influenza A virus M2 is required to block the fusion of autophagosomes with lysosomes. (A)TREx-293 cells carrying tetracycline-inducible H5N1-M2 (S31) or H5N1-M2 (N31) were ...
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First International Proton Channel Meeting in Villars, Switzerland, September 13-
... 51. Musset, B., V.V. Cherny, D. Morgan, Y. Okamura, I.S. Ramsey, D.E. Clapham, and T.E. DeCoursey. (2008). Detailed comparison of expressed and native voltage-gated proton channel currents. Journal of ...
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Identification of a vacuolar proton channel that triggers the bioluminescent flash in dinoflagellates
... a proton channel to open only during the action potential in scintillon membranes, it was later realized that the same channel could also mediate the action potential in the tonoplast ...
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Perspective The gp91 phox Component of NADPH Oxidase Is Not a Voltage-gated Proton Channel
... H channel properties change during activation of NADPH oxidase; there is one channel with two gating ...voltage-gated proton channels are radically different than in cells studied under con- ...
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Biophysical properties of the voltage-gated proton channel H 1 Boris Musset and Thomas DeCoursey
... (VCF) to simultaneously measure the changes of a fluorophore at position S242C on top of the S4 domain in the Ciona intestinalis proton channel while recording the current in oocytes with two-electrode ...
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Identification of Thr 29 as a Critical Phosphorylation Site That Activates the Human Proton Channel Hvcn1 in Leukocytes
... Voltage-gated proton channels and NADPH oxidase function cooperatively in phagocytes during the respiratory burst, when reactive oxygen species are produced to kill microbial ...enhance proton chan- nel ...
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Energy Based Pharmacophore Modelling and Docking Studies for Determining Potent Inhibitor Against M2 Proton Channel of Influenza Virus
... In this study, we have made an attempt at finding novel drugs that would inhibit the action of M2 proton channel by using already existing potent anti-viral drugs. Com- putational approaches such as virtual ...
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Structure-Based Design of Inhibitors Targeting Influenza A Virus M2 Proton Channel (A/M2)
... tetramerization, proton channel formation, and drug binding 3 ...N-terminal channel lumen, surrounded by residues mutated in amantadine-resistant viruses, consistent with the X-ray ...
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Construction and validation of a homology model of the human voltage-gated proton channel hH 1
... polarization-activated proton channel (R1 → His), a pro- ton carrier (R2 → His or R3 → His), or a depolarization activation proton channel (R4 → ...
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pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1
... the channel was not discovered until 2006 when two groups cloned human and murine HVCN1 genes [8,9], which prompted a wave of new studies on voltage-gated proton channel function and ...torically, ...
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Voltage-gated proton channel in a dino agellate
... dinoflagellate proton channel gene, express the protein heterologously, characterize the electro- physiological properties of the protein, and compare key struc- tural elements with those elements in known ...
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Detailed comparison of expressed and native voltage-gated proton channel currents
... human proton channel was expressed in HEK-293 cells (downward green triangles), the mouse channel in COS-7 cells ...Native proton currents are from other studies in THP-1 cells (upward ...
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The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma Thomas E. DeCoursey
... a channel with a million-fold preference for protons would still end up allowing other ions to permeate more than half the ...the channel in most ...the proton channel needs a relative ...
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Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hH 1
... That proton selectivity was restored to D112V and D112A mutants by introducing Asp at position 116 sug- gests that the intramolecular interactions at both posi- tions that contribute to proton selectivity ...
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Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hH 1
... produce proton-selective conduction without requiring contribution from the rest of the protein beyond providing a scaffold and focusing aqueous access to the selectivity filter (Dudev et ...to ...
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Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells
... where proton channels sus- tain B-cell receptor (BCR) signaling via regulation of reactive oxygen species production by the NADPH oxidase enzyme com- plex ...cells, proton channels prevent excessive ...
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Selectivity Mechanism of the Voltage-gated Proton Channel, H V
... region that dictates proton selectivity, but the mechanism of proton selectivity is unknown. Here we use a reduced quantum model to elucidate how the Asp–Arg SF selects protons but excludes other ions. ...
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Aspartate 112 is the selectivity filter of the human voltage-gated proton channel
... mutant channel lost proton spe- cificity and became anion-selective or did not ...remained proton-specific. Mutation of the nearby Asp 185 did not impair proton selectivity, indicating that ...
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Consequences of Dimerization of the Voltage-Gated Proton Channel
... of proton channels in phagocytes (neutrophils, mac- rophages, and eosinophils) is to facilitate and sustain NADPH oxidase (or “Nox2”) ...65,67–70 Proton efflux through H V 1 compensates for both the ...
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New Methods To Assess Protein Folding And Conformational Dynamics
... Conformational dynamics studies on biomolecules have gained an explosive growth over the past 50 years since the first crystal structures of myoglobin and DNA were published in the 1950s. 1-3 The reason that ...
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