Protozoan parasite
Characterization of Metacaspases with Trypsin-Like Activity and Their Putative Role in Programmed Cell Death in the Protozoan Parasite Leishmania
... In summary, this represents the first report of the enzymatic properties of native metacaspases purified from a protozoan parasite. Leishmania metacaspases share some similarities with yeast and plant ...
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A Genomewide Overexpression Screen Identifies Genes Involved in the Phosphatidylinositol 3-Kinase Pathway in the Human Protozoan Parasite Entamoeba histolytica
... E ntamoeba histolytica is an enteric protozoan parasite that causes amoebiasis and amoebic liver abscess in humans (1). It is prevalent in developing countries that cannot prevent its fecal- oral spread. E. ...
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Pair of Unusual GCN5 Histone Acetyltransferases and ADA2 Homologues in the Protozoan Parasite Toxoplasma gondii
... GCN5 is a histone acetyltransferase (HAT) essential for development in mammals and critical to stress responses in yeast. The protozoan parasite Toxoplasma gondii is a serious opportunistic pathogen. The ...
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Proteomic Analysis of Phagocytosis in the Enteric Protozoan Parasite Entamoeba histolytica
... The protozoan parasite Entamoeba histolytica is a major cause of morbidity and mortality worldwide (35). E. histolytica is capable of ingesting microorganisms in the large intestine (5), as well as red ...
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The protozoan parasite Trichomonas gallinae causes adult and nestling mortality in a declining population of European Turtle Doves, Streptopelia turtur
... Stockdale, JE, Dunn, JC, Goodman, SJ et al. (4 more authors) (2015) The protozoan parasite Trichomonas gallinae causes adult and nestling mortality in a declining population of European Turtle Doves, ...
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Lysine Acetylation Is Widespread on Proteins of Diverse Function and Localization in the Protozoan Parasite Toxoplasma gondii
... identify parasite peptides enriched by immunopurification with acetyl-lysine antibody, we produced the first proteome-wide analysis of acetylation for a protozoan organism, the opportunistic apicomplexan ...
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The Unfolded Protein Response in the Protozoan Parasite Toxoplasma gondii Features Translational and Transcriptional Control
... RNA purification. Fractions from the polyribosome analysis were pooled into two groups: free and monoribosomal RNA (fractions 1 to 5) and polyribosomal RNA containing three or more associated ribosomes (fractions 7 to ...
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Iron-Inducible Nuclear Translocation of a Myb3 Transcription Factor in the Protozoan Parasite Trichomonas vaginalis
... the protozoan para- site imposes a heavy burden on public health, especially when trichomoniasis is recognized as one of the major risk factors in promoting transmission of the human immunodeficiency virus (HIV) ...
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Systemic and Cutaneous Mucus Antibody Responses of Channel Catfish Immunized against the Protozoan Parasite Ichthyophthirius multifiliis
... against parasite challenge ...by parasite activity or adjuvant seems to play a critical role in eliciting acquired protective immunity against the ...
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Mass Spectrometric Analysis of l Cysteine Metabolism: Physiological Role and Fate of l Cysteine in the Enteric Protozoan Parasite Entamoeba histolytica
... in this parasite. Stable-isotope tracing is a powerful technique to investigate the metabolism of different carbon and nitrogen sources in microbial pathogens, such as Salmonella enterica sero- var Typhimurium ...
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TgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondii
... FIG 1 Ablation of K40 acetylation is not tolerated unless it is replaced with the K40Q acetyl-lysine mimic. (A) Diagram of TgTUBA1 genomic locus aligned with the construct used to replace the endogenous locus by double ...
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The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates
... targeting protozoan parasites remains challenging, partly due to the complex inter- actions between these eukaryotes and the host immune ...apicomplexan parasite that causes enteritis and diarrhea in ...
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Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system
... The integration and transcription of transgenes, both for vvVP2 or gI, was shown in all the transgenic popula- tions and for gI it was possible by Western blotting to identify proteins of the expected mass within ...
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Artemisinin Induces Calcium-Dependent Protein Secretion in the Protozoan Parasite Toxoplasma gondii
... Artemisinin treatment of T. gondii resulted in calcium-de- pendent secretion of microneme proteins as detected by re- lease of MIC2 into the supernatant, similar to the SERCA inhibitor thapsigargin. While artemisinin ...
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A Highly Organized Structure Mediating Nuclear Localization of a Myb2 Transcription Factor in the Protozoan Parasite Trichomonas vaginalis
... Intriguingly, the protein sequence mediating nuclear localiza- tion of Myb2 was mapped to a contiguous region spanning aa 48 to 143, referred to as the nuclear localization domain (NLD), which encompasses nearly the ...
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Proteomic and transcriptomic analysis of the Protozoan Parasite Neospora caninum
... The aim of this experiment was to determine whether there were changes in mRNA expression during stage conversion of N. caninum tachyzoites to bradyzoites. This was seen to be the case, and when subgroups of genes were ...
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Multifarious Transcriptional Regulation of Adhesion Protein Gene ap65-1 by a Novel Myb1 Protein in the Protozoan Parasite Trichomonas vaginalis
... Iron availability, which periodically varies in the human va- gina, where the parasite colonizes, regulates the cytoadherence of T. vaginalis, possibly through controlling the expression of several adhesion ...
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Biosynthesis of Glycosylphosphatidylinositol Is Essential to the Survival of the Protozoan Parasite Toxoplasma gondii
... a product of ⬃4.6 kb from both the wild-type and pseudodiploid PIGA alleles (Fig. 3A). Type I ⌬PIGA pseudodiploids were not detected in any of the six independent populations from the parental parasites. However, they ...
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Transcript Diversity In The Protozoan Parasite Toxoplasma Gondii
... Humans and other vertebrates become infected with T. gondii through the ingestion (or injection) of oocysts from the environment (contaminated soil or water) or tissue cysts from contaminated meat. Excystation is ...
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Transcriptional Regulation of an Iron-Inducible Gene by Differential and Alternate Promoter Entries of Multiple Myb Proteins in the Protozoan Parasite Trichomonas vaginalis
... Myb3 is expressed in T. vaginalis as ⬃ 32-kDa doublet pro- teins with differential distributions in the cytoplasm and nu- cleus (Fig. 2), suggesting that Myb3 likely undergoes posttrans- lational modification(s) before ...
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