PSGL-1
Caveolar Endocytosis Is Required for Human PSGL-1-Mediated Enterovirus 71 Infection
... in 1 ⫻ PBS before run on a FACScan flow cytometer and analyzed using FCS Express V3 (De Novo ...0.5, 1, 3, 6, and 24 ...(Table 1) (C) and protein expression by immunoblotting with anti-clathrin or ...
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Perspectives series: cell adhesion in vascular biology Role of PSGL 1 binding to selectins in leukocyte recruitment
... the PSGL-1 core protein is expressed prima- rily in hematopoietic cells (15, ...platelets. PSGL-1 is ex- pressed on virtually all leukocytes, but at lower levels on B ...to ...
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PSGL 1–mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells
... of PSGL-1 by siRNA reversed the proangiogenic and adhesive effects of EphB4 ...of PSGL-1 expression and adhesion to E selectin and P ...
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Basic Motifs Target PSGL-1, CD43, and CD44 to Plasma Membrane Sites Where HIV-1 Assembles
... among PSGL-1 ...of PSGL-1 enhances coclustering with HIV-1 ...mutant PSGL-1 ...WT PSGL-1 and PSGL-1 mutants were expressed in HeLa cells, and ...
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The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR-/- mice
... 8+8w, 8+12w and 8+16w in order to reveal the effect of PSGL-1 deficiency on atherosclerosis. The HE, Oil red O and Sirius red staining of aortic roots at 8 weeks presented a good preservation of aortic wall ...
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Original Article Expression of P-selectin, VCAM-1, and PSGL-1 in traumatic deep venous thrombosis
... scription. Normally, NF-κB specific inhibitory protein I-κB binding with NF-κB dimers locates in cytoplasm. TNF-α or endotoxin stimulus acti- vates I-κB kinase (IKK), leading to I-κB phos- phorylation and NF-κB ...
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Neutrophil neutrophil interactions under hydrodynamic shear stress involve L selectin and PSGL 1 A mechanism that amplifies initial leukocyte accumulation of P selectin in vitro
... neutrophil PSGL-1, a sialomucin glycoprotein that serves as a ligand for both P- and E-selectin, can also support the attachment and rolling of free flowing neutrophils in ...on PSGL-1 was ...
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The development of salt-sensitive hypertension regulated by PSGL-1 gene in mice
... high salt diet was accompanied with increased expres- sion of serum inflammatory cytokines IL-6, IL-1β and TNFɑ, and renal macrophages and T cells infiltration. IL-6, IL-1β and TNFɑ are mainly secreted by activated ...
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Cell Surface Nucleolin Facilitates Enterovirus 71 Binding and Infection
... SCARB2, PSGL-1 mediates the infection of some, but not all, EV71 strains or geno- types (7, ...addition, PSGL-1 participates in EV71 virus bind- ing but not virus entry and viral RNA release ...
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The cytokine adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney Inhibition by a soluble P selectin ligand
... can serve as a ligand for all three selectin family members: P-, E-, and L-selectin (9, 43–46). A recombinant soluble form of PSGL-1, sPSGL, was used in these experiments to investi- gate the role of these ...
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Selectin ligands: will the real ones please stand up?
... (71, 72). A more promising candidate may be a relatively un- usual Core 2 branched sialylated polyfucosylated O-linked chain found in a small copy number on PSGL-1 (32); however, this has not yet been ...
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Neutrophils use both shared and distinct mechanisms to adhere to selectins under static and flow conditions
... Both P-selectin glycoprotein ligand-1 (PSGL-1) and L-selectin are localized on the microvilli of neutrophils and have been implicated in the attachment of neutrophils to P-selectin or E- selectin. We ...
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Generation of soluble P and E selectins in vivo is dependent on expression of P selectin glycoprotein ligand 1
... between PSGL-1 and P-sel, because mice lacking a(1,3)-fucosyltransferase-VII are also deficient in ...sP-sel. Psgl-1 )/) mice are also deficient in soluble E-selectin (sE-sel) indicating that ...
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Wichmann, Christian (2019): Mechanismen und molekulare Zielstrukturen in der leukämischen CD34+ Blutvorläuferzell-Expansion. Habilitationsschrift, LMU München: Medizinische Fakultät
... beeinflusst PSGL-1 auch das Homing von hämatopoetischen Stammzellen in die ...die PSGL-1-Zelloberflächenexpression deutlich reduzieren, was nahelegt, dass RUNX1/ETO ausreichend ist, die ...
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Gauß, Alexandra (2008): Der Einfluss des Adhäsionsmoleküls GPVI-aCD133 auf die Adhäsion von endothelialen Progenitorzellen in zwei Gefäßverletzungsmodellen der Maus: Untersuchungen mit Hilfe der Intravitalmikroskopie. Dissertation, LMU München: Tierärztliche Fakultät
... Während aktivierte Thrombozyten über P-Selektin mit PSGL-1 (P-selectin glycoprotein ligand-1) der CD34 + Progenitorzellen interagieren und den Prozess des Rollens vermitteln, [r] ...
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P selectin glycoprotein ligand 1–deficient mice have impaired leukocyte tethering to E selectin under flow
... Generation of PSGL-1–deficient mice. Electroporation was used to transfect the targeting vector into CJ7 ES cells (originating in a 129/SvlmJ mouse, a gift from Thomas Sato, University of Texas Southwestern ...
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Heparin’s anti inflammatory effects require glucosamine 6 O sulfation and are mediated by blockade of L and P selectins
... well as recombinant PSGL-1 (61, 62). As these selectin inhibitors have various drawbacks, such as narrow cross-reactivity, weak affinity, relatively little selectivity among the selectins, short circulating ...
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Pyrimidin 2 amine–1 phenylcyclopentane 1 carboxylic acid (1/1)
... For the structure of pyrimidin-2-amine, see: Scheinbeim & Schempp (1976) and for the structure of 1-phenylcyclo- pentane-1-carboxylic acid, see: Margulis (1975). For molecular co-crystals of ...
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1 Acetamido 1 (1 naphthyl)ethylene
... Enamides were extensively studied for practical use as the prochiral materials for the asymmetric synthesis of chiral amines, which can be used as resolving reagents, chiral auxiliaries and intermediates for the ...
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Vol 1, No 1
... It is generally accepted that The Book of Dede Korkut was put down into writing in the ninth century (Ergin 1989: 56) and Beowulf was put down into writing some time between the middle of the seventh and the end of the ...
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