PTEN and Disease
PTEN induced partial epithelial mesenchymal transition drives diabetic kidney disease
... of PTEN in kidney disease remain unclear. We report that PTEN promotes TGF-β, SHH, CTGF, IL-6, and hyperglycemia-induced EMT when PTEN is modified with a K27- linked polyubiquitin chain ...
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Hereditary breast cancer associated with Cowden syndrome-related PTEN mutation with Lhermitte-Duclos disease
... Abstract Background: Cowden syndrome is characterized by multiple hamartomas in various tissues, including the skin, brain, breast, thyroid, mucous membrane, and gastrointestinal tract, and is reported to increase the ...
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PTEN Depletion Decreases Disease Severity and Modestly Prolongs Survival in a Mouse Model of Spinal Muscular Atrophy.
... of disease, and this is clearly a promising therapeutic approach for ...for PTEN knockdown to ameliorate disease pathology in SMA, since we first reported that experimental targeting of PTEN ...
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PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in pulmonary emphysema and chronic obstructive pulmonary disease with resected lung squamous cell carcinoma
... pulmonary disease, GOLD Global Initiative for Chronic Obstructive Lung Disease, PD-L1 Programmed death ligand 1, TC Tumor cells, IC Immune cells, FGFR1 Fibroblast growth factor receptor 1, PIK3CA ...
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PTEN A REVIEW
... in PTEN induces macrocephaly and autistic syndrome in mice 10 ...which PTEN could be a Therapeutic Target: The current study also explains its role in various other diseases such as Parkinson’s, Alzheimer’s ...
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The PTEN conundrum: how to target PTEN-deficient prostate cancer
... suppressor PTEN is a frequent event in prostate cancer that contributes to tumor growth and therapeutic resistance through oncogenic PI3K–AKT–mTOR signaling, increased genomic instability, impaired DNA damage ...
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PTEN deficiency: a role in mammary carcinogenesis
... Cancer is a multi-step process involving the mutation of genes regulating cell proliferation, differentiation, and sur- vival, leading to escape from normal tissue boundaries and sustained angiogenesis [2]. Given the ...
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Regulation of PTEN expression by noncoding RNAs
... artery disease; CASC2: Cancer susceptibility candidate 2; CCRCC: Clear-cell renal cell carcinoma; ceRNAs: Competing endogenous RNAs; CK2: Formerly casein kinase II; CSCs: Cancer stem cells; DNMTs: DNA ...
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PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway
... and PTEN expression in BC tissues and cell lines, and the results showed down- regulation in BC tissues compared with adjacent normal ...and PTEN to be closely re- lated to advanced TNM stage and overall ...
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Studies of the PTEN tumour suppressor in endometrial cancer
... 1.2 PTEN Tumour Suppressor & PI3K Signalling The importance of regulating intracellular s ignalling is dramatically illus trated by the many disorders resulting from mutation or otherwise inactivation of the genes ...
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Pten Function in Postnatal Brain Development and Tumorigenesis
... of Pten at birth resulted in disorganization and hypertrophy of cerebellum which mimics human Lhermitte-Duclos disease We induced the deletion of Pten in the Nestin-CreER T2 ;Pten loxP/loxP ...
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PTEN Methylation Dependent Sinonasal Mucosal Melanoma
... multiple liver and bone metastases, with an epigenetic alter- ation of PTEN promoter. As the patient was not considered amenable for surgical excision due to the presence of distant metastases, she was treated ...
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Differential expression of PTEN gene correlates with phenotypic heterogeneity in three cases of patients showing clinical manifestations of PTEN hamartoma tumour syndrome
... colon carcinoma, showed macrocephaly with a square cra- nium and a broad asymmetry of the cerebral hemispheres, glycogenic acanthosis of the esophagus, penis macules, keratosis of the hands and feet and ilo-splenic ...
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Loss of nuclear PTEN in HCV-infected human hepatocytes
... of PTEN-dependent large lipid droplets in hepatocytes [7] implicates a direct viral role in liver ...of PTEN translocation to the nucleus in HCV-infected ...of PTEN in HCV- infected cells results ...
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Diffuse Gastric Ganglioneuromatosis: Novel Presentation of PTEN Hamartoma Syndrome—Case Report and Review of Gastric Ganglioneuromatous Proliferations and a Novel PTEN Gene Mutation
... pain, and fecal withholding. Her medical history was sig- nificant for prematurity, born at twenty-five weeks gestation and related conditions of prematurity including retinopathy, anemia, and lung disease. She was ...
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Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression
... SPRY2, PTEN, and PP2A ...with PTEN and PP2A (P < 0.001). Furthermore, altered SPRY2, PTEN, and PPP2CB expression was associated with aggressive PC and decreased disease-free ...nuclear ...
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Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer
... metastatic disease. PTEN, a critical tumor and metastasis suppressor gene negatively regulates cell survival, proliferation, migration and angiogenesis via the PI3K/Akt ...pathway. PTEN is mutated, ...
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Medulloblastoma, macrocephaly, and a pathogenic germline PTEN variant : Cause or coincidence?
... Lhermitte-Duclos disease, and autism spectrum disorders with macrocephaly (Pilarski, 2019; Tan et ...germline PTEN mutations has been pro- ...germline PTEN variants followed up by Tan and colleagues ...
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In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself
... functional PTEN, while in 786-O cells the PTEN gene bears a ...of PTEN-Δ overexpression on the analyzed cellular processes could be ...that PTEN-Δ acts as a new tumor suppressor for ...
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The PTEN-PI3K Axis in Cancer
... with specific loss of PTEN protein phosphatase activity only and intact lipid function as observed. 298[r] ...
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