PTEN/PI3K/AKT pathway
JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer
... the PI3K/AKT ...for PTEN developed endometrial hyperplasia, atypical hyperplasia and endometrial carcinoma [35, ...of PTEN is likely an early event in endometrial tumorigenesis and likely ...
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PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway
... signaling pathway, PI3K/Akt pathway plays a pivotal role in the development of many cancers, including BC ...of PI3K/Akt pathway in BC has been declared, ...
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Original Article Evaluation of AKT phosphorylation and PTEN loss and their correlation with the resistance of rituximab in DLBCL
... mortality. PTEN/PI3K/AKT signal pathway is constitutively activated and plays an oncogenic role in most tu- mors including non-Hodgkin’s lymphoma ...of PTEN/PI3K/ AKT ...
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Original Article Curcumin promotes apoptosis of breast cancer cells by down-regulating DJ-1-PTEN/PI3K/AKT signaling pathways
... the PI3K/AKT signal pathway is correlated with ...of PTEN, DJ-1 over-expression is associated with the occurrence of multiple ...the PTEN-PI3K/AKT ...and PTEN mRNA ...
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Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway
... response. PTEN is able to antagonize the activity of PI3K by converting PI (3, 4,5) P3, which plays a leading role in the phosphorylation of AKT, into PI (4,5) P2, achieving negative regulation of ...
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Isatin Inhibits SH-SY5Y Neuroblastoma Cell Invasion and Metastasis through LSD1 Activity Inhibition
... the PI3K/ AKT signaling pathway which is highly related to invasion and metastasis of cancer cells [21, 22] ...instance, PTEN inhibits the migration and invasion of HepG2 cells by coordinately ...
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<p>SPOCD1 accelerates ovarian cancer progression and inhibits cell apoptosis via the PI3K/AKT pathway</p>
... Background: Ovarian cancer (OC) is the most common type of gynecological malignant tumors with poor prognosis. The spen paralogue and orthologue C-terminal domain contain- ing 1 (SPOCD1) is a newly identi fi ed molecule ...
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Regulation of PTEN expression by noncoding RNAs
... stemness. PTEN induces autophagy through repressing PI3K/Akt pathway, while miR-21 elevation was found in human degenerative nucleus pulposus tissues, which in- hibits autophagy and induces ...
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Original Article The expression of PI3K/Akt signaling pathway and PTEN in hippocampus of the brain and the correlation with cognitive impairment after neonatal hypoxic ischemic brain damage in rats
... the PI3K/ Akt signaling pathway that prevents the re- cruitment of AKT to the cellular membrane for phosphorylation ...that PI3K/Akt pathway and PTEN is related to ...
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PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.
... of PTEN in PARK2-mediated regulation of the PI3K/Akt pathway, we performed PARK2 knockdown analysis in cell lines with abundant Parkin, but either WT PTEN present (HCT116 and H460) or ...
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Original Article Lipopolysaccharide activated TLR4/NF-κB signaling pathway of fibroblasts from uterine fibroids
... of PTEN downregulation and PI3K-Akt pathway activation [35], while He ZW inferred that lipopolysaccharide maybe acti- vate rheumatoid synovial fibroblasts via p38 MAPK and NF-κB signaling ...
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Trichilemmomal Horn Arising from a Nevus Sebaceus and Pilar Cyst: A Case Report and Review of the Literature
... Mammalian target of rapamycin (mTOR) is a part of the final common pathway for HRAS and PTEN. As such, mTOR is a likely target for therapies of neoplasms involving the PI3K/Akt pathway ...
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MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K/Akt/eNOS signaling pathway
... the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate [19, ...targeting PTEN through the PI3K/Akt/eNOS signaling ...
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PTEN opathies: from biological insights to evidence based precision medicine
... the PTEN-opathies (Table 3). As such, AKT and PIK3CA inhibitors have been used in PS and PIK3CA-related overgrowth spectrum (PROS) disorders ...of PI3K. Preclinical studies using the allosteric ...
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Original Article PTEN is involved in Kanglaite injection-induced apoptosis of human pancreatic cancer cells
... The PI3K/Akt/mTOR signaling pathway be able to progress cell survival and proliferation in various ...cancers. PTEN (Phosphatase and tensin homolog deleted on the chromosome 10) is a major ...
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Advances in Targeting Signal Transduction Pathways.
... the PI3K/PTEN/Akt/mTORC1 pathway ...and PI3K/PTEN/Akt/mTORC1 pathways are regulated by extensive crosstalk, occurring at different ...alternate pathway is a ...
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Genomic landscape of salivary gland tumors
... the PI3K pathway (PIK3CA, PIK3R1, PTEN or AKT) were commonly seen in salivary gland tumors (28/117 ...and PI3K pathway abnormalities (10/13 ...4). PI3K and RAS are key ...
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MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
... MiR-16-1-3p and miR-16-2-3p together with miR- 16-5p were demonstrated to be down-regulated in OS and mouse model with engineered WWOX gene [101–104], while tumor suppressive effects of 16-1-3p and miR-16-2-3p were ...
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Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
... the PI3K/Akt/mTOR pathway via RAGE Western blot assay shows that the AGEs treatment stimu- lated the RAGE expression, however, inhibited the PI3K/ Akt/mTOR pathway in cultured ...
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Original Article UBE2T silencing inhibits TGF-β1-induced epithelial-to-mesenchymal transition in colon cancer cells
... Abstract: Epithelial-mesenchymal transition (EMT) is considered as the first and key step for the migration and inva- sion of cancers including colon cancer. Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the E2 ...
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