Purinergic receptor
Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection
... Purinergic receptor agonists and ...the purinergic receptor ...anti-P2X7 receptor antibody raised in rabbit (OriGene, Rockville, ...of purinergic receptor agonist and ...
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Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3β/β-catenin axis in mesenchymal stem cells under osteogenic induction
... Among the possible molecular mechanisms of EMF treatments, one of the popular theories is that the therapeutic effect of EMFs against osteoporosis is medi- ated by the production of excessive voltage-gated cal- cium ...
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P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients
... P2 purinergic receptors are overexpressed in certain cancer tissues, but the pathophysiologic relevance of purinergic signaling in hepatocellular carcinoma (HCC) remains ...P2 purinergic signaling in ...
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P2 purinergic receptor agonists inhibit the growth of androgen independent prostate carcinoma cells
... P2-purinergic receptor agonists, including ATP and certain hydrolysis-resistant adenine nucleotides, induced a rapid, transient increase in cytoplasmic free Ca2+ that was detectable at 50 to 100 nM ATP, was ...
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Bradykinin increases resensitization of purinergic receptor signaling in glioma cells
... The effects of bradykinin on ATP-mediated signaling could play multiple functional roles in the nervous sys- tem. B2 receptors are highly expressed on glioma cells, and the expression of these receptors may be correlated ...
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purinergic receptor regulates steroid synthesis and proliferation of ovarian luteal cells
... Abstract: Aim: As an important messenger, Uridine 5’-diphosphate (UDP) is involved in series of physiological and pathological processes through activating P2Y 6 purinergic receptor. However, the detailed ...
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Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation
... Purinergic receptors participate, in almost every cell type, in controlling metabolic activities and many physiological functions including signal transmission, proliferation and differentiation. While most of P2Y ...
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Apical membrane P2Y4 purinergic receptor controls K+ secretion by strial marginal cell epithelium
... The purinergic receptor antagonist, suramin, was tested for effectiveness in blocking the response to apical ...4 receptor subtypes have been reported to undergo desensitization within 5–15 min ...
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H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway
... P2-purinergic receptor family that are coupled to trimeric G proteins ...P2Y6 receptor has also been reported to protect normal cells from apoptosis induced by TNF-α ...to purinergic ...
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Epithelial P2X purinergic receptor channel expression and function
... P2X purinergic receptor (P2XR) channels bind ATP and mediate Ca 2+ influx — 2 signals that stimulate secretory Cl – transport across epithelia. We tested the hypotheses that P2XR channels are expressed by ...
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ATP and purinergic receptor–dependent membrane traffic in bladder umbrella cells
... by purinergic signaling cascades, and these may provide important drug targets for bladder disorders such as interstitial cystitis, urge incontinence, outlet obstruction, and female idiopathic detrusor instability ...
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A purinergic P2Y6 receptor agonist prodrug modulates airway inflammation, remodeling, and hyperreactivity in a mouse model of asthma
... P2Y6 purinergic receptor belongs to the family of P2 receptors which con- sist of P2X ligand-gated ion channels and P2Y G-protein coupled ...P2 receptor family has several recep- tor subtypes with ...
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The role of microglia in viral encephalitis: a review
... the purinergic receptor P2Y12 and are recruited around infected neurons to exert phagocytic ...activating receptor-interacting protein kinases 3 (RIPK3) in a death-independent pathway, the RIPK3 ...
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Hypoxia attenuates purinergic P2X receptor-induced inflammatory gene expression in brainstem microglia
... P2X purinergic receptor ...P2X receptor activation alone affects inflammatory molecule production in brainstem microglia, nor how hypoxia and P2X receptor signaling interact when they occur ...
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The role of the purinergic P2X7 receptor in inflammation
... a purinergic receptor (suggested to be the P2X 7 R) which when inhib- ited, severely decreased cell proliferation ...endogenous receptor expression), sustained their growth in serum-free medium ...
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Lack of a functioning P2X7 receptor leads to increased susceptibility to toxoplasmic ileitis
... These funding bodies played no part in the experimental design, collection of data, interpretation, Principal Findings Mice lacking the purinergic receptor P2X7R are acutely susceptible [r] ...
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P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction
... the purinergic receptor P2Y 2 and the G proteins G q /G 11 mediate fluid shear stress–induced endothelial responses, including [Ca 2+ ] i transients, activation of the endothelial NO synthase (eNOS), ...
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P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice
... through purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P2rx7) induced activation (decryption) of TF procoagulant activity and promoted release of TF + MPs from ...
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Purinergic targeting enhances immunotherapy of CD73+ solid tumors with piggyBac-engineered chimeric antigen receptor natural killer cells
... of purinergic CD73 blockade on NK cell im- munotherapy has not yet been demonstrated, and though it was suggested that NK cells respond to CD73 targeting via mechanisms that are antibody-dependent cellular ...
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Purinergic signalling in bone cells
... P2Ye receptor, pointing to a ‘dual nature’ of agonists at these receptors: low concentrations between ...‘two-site’ receptor model has been proposed, with two distinct ligand-binding sites on one ...
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