Purkinje-Cell
Spatiotemporal Analysis of Purkinje Cell Degeneration Relative to Parasagittal Expression Domains in a Model of Neonatal Viral Infection
... life. Purkinje cell (PC) damage has been reported for several models of early-life viral infection, including NBD; however, the time course and distribution of PC pathology have not been investigated ...
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PCP4 regulates Purkinje cell excitability and cardiac rhythmicity
... Cardiac Purkinje cells are important triggers of ventricular arrhythmias associated with heritable and acquired syndromes; however, the mechanisms responsible for this proarrhythmic behavior are incompletely ...of ...
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Neurogenin 2 regulates progenitor cell cycle progression and Purkinje cell dendritogenesis in cerebellar development
... Tissues were prepared as described (Croci et al., 2006). Mouse primary antibodies: calbindin, parvalbumin (1:1500; Swant, Bellinzona, Switzerland); SMI32 (1:250; Sternberger Monoclonals, Lutherville, MD, USA); NeuN ...
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Mathematical model of bursting in dissociated Purkinje neurons
... full Purkinje cell morphology, its inherent trimodal (or tonic) firing pattern can be eventually replaced with a phase of bursting and then a depolarisation block ...isolated Purkinje somata ...
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Distinct roles of neuroepithelial like and radial glia like progenitor cells in cerebellar regeneration
... few cell types of distinct ...(ML), Purkinje cell layer (PL) and granule cell layer ...contains Purkinje neurons (PN), specialised Bergmann glia (BG), and excitatory eurydendroid cells ...
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Xenografting of human umbilical mesenchymal stem cells from Wharton’s jelly ameliorates mouse spinocerebellar ataxia type 1
... (1:100, Cell Signaling 2177) and anti-human specific nuclei antigen (1:100, Millipore MAB1281) immunohisto- chemical ...of Purkinje cells in the cerebellum also declined in these two ...of Purkinje ...
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Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model
... PF–Purkinje cell synapse was induced in current clamp mode by either pairing PF and CF stimulation at 1 Hz for 5 minutes (PF-LTD protocol) at a near-physiological temperature (34°C ± 1°C) or by PF ...
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Original Article Long non-coding RNA plays a role in aldosterone-producing adenoma through PCP4
... In this study, we first used microarray to obtain the mRNA and lncRNA profiles of 6 APA tissues and 6 normal adrenal cortical (NAC) tissues. Second, we chose Purkinje cell protein 4 (PCP4) as a study target ...
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The sodium potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron
... switches Purkinje cell activity out of the trimodal firing pattern and into a continuous burst ...whole cell patch clamp recording from a Purkinje cell (with 10 mM bicuculline already ...
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AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival
... appeared normal. However, at about 8 weeks, they began to show unsteady gait in the cage. Histological examination of the cerebella from these mice showed dramatic degeneration of PCs over time (Figure 1). Prominent loss ...
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Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster
... model Purkinje cell is switched from a trimodal pattern of spontaneous firing into ...the Purkinje cell model progress through a number of activity states (Figure ...observed Purkinje ...
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Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA damage response in Purkinje neuron progenitors
... The distribution of the Zfp423 transcript in the embryonic CNS has been described previously (Alcaraz et al., 2006; Cheng et al., 2007; Masserdotti et al., 2010; Warming et al., 2006). Here, we report the tissue and ...
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His Purkinje conduction during retrograde stress
... The pattern of retrograde His-Purkinje conduction was evaluated in 28 patients using ventricular extrastimuli. In each patient progressive prolongations of His-Purkinje conduction (S2H2) which appeared as ...
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Nkx2 5 mutation causes anatomic hypoplasia of the cardiac conduction system
... Connexin immunohistochemistry. Hearts were snap-frozen in liquid nitrogen, embedded in OCT, and sectioned (8-µm thickness). Alter- nate consecutive sections were histochemically stained with H&E. Immunofluorescent ...
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The Distribution of the Stress Protein HSP70 in the Cerebellum of Patients with Schizophrenia
... 0.2 g of the brain fresh sections from 5 controls and 3 schizophrenics were homogenized in 2 ml homogeniza- tion buffer (pH 7.5): 50 mM Tris hydroxymethyl ami- nomethane (Merck, Germany), 1 mM EDTA (Bio-Rad, USA), 1% ...
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Efficient Numerical Schemes for Computing Cardiac Electrical Activation over Realistic Purkinje Networks: Method and Verification
... a Purkinje network is based on the bidomain equations [6], or on the cable equation with a reaction term ...the Purkinje con- duction system as a branching tree of conducting segments without ...the ...
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Effect of lidocaine hydrochloride on membrane conductance in mammalian cardiac purkinje fibers
... cardiac Purkinje fibers by decreasing the slope of slow diastolic depolarization, but the mechanisms of this effect are poorly ...in Purkinje fibers perfused with sodium-deficient Tyrode containing choline ...
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Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model
... at 0.3-μm intervals using a PerkinElmer UltraVIEW Spinning Disk Confocal Microscope. Analyses of soma and dendrite area and total mitochondria volume were performed using Volocity 3D Image Anal- ysis Software, version ...
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Antiadrenergic effects of adenosine on His Purkinje automaticity Evidence for accentuated antagonism
... The effects of adenosine on the human His-Purkinje system (HPS) were studied in nine patients with complete atrioventricular (AV) block. Adenosine had minimal effect on the control HPS cycle length, but in the ...
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Effects of alternating cycle lengths on refractoriness of the His Purkinje system
... atrioventricular nodal conduction (699 +/- 90 vs. 743 +/- 87 ms, P less than 0.001), the relative refractory period of the His-Purkinje system was always longer with method II (463 +/- 52 vs. 440 +/- 43 ms, P less ...
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