Pyruvate dehydrogenase kinase
A Comparative Docking Studies of Dichloroacetate Analogues on Four Isozymes of Pyruvate Dehydrogenase Kinase in Humans
... four Pyruvate dehydrogenase kinases (PDKs) that regulate the mammalian Pyruvate dehydrogenase complex (PDC) are a novel class of kinases that are expressed in most ...a pyruvate mimetic ...
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Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model
... of pyruvate dehydrogenase kinase (PDK)-1 and nuclear c-Myc, peroxisome proliferator–activated receptor- γ coactivator (PGC)-1 α and NF-E2-related factor (NRF)2 after T-H and after treatment with ...
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Antisense knockdown of pyruvate dehydrogenase kinase promotes the neutral lipid accumulation in the diatom Phaeodactylum tricornutum
... In PDHK4 knockout mice, the promoted fat accu- mulation and reduced fatty acid oxidation resulted from activation of PDC by lower phosphorylation of PDC through repressing the expression of PDHK (pyruvate ...
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Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells
... Altered metabolism has been recognized as a hallmark of cancer [8]. Tumor cells need to consume more glucose and glutamine to satisfy the energy demand and biosynthesis re- quirement for rapid proliferation. Although ...
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Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle
... What is the mechanism behind high-fat diet-induced insulin resistance? It has been shown that chronic high- fat diet-induced insulin resistance, unlike insulin resist- ance induced by acute increase in plasma free fatty ...
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Molecular docking studies of (4Z, 12Z) cyclopentadeca 4, 12 dienone from Grewia hirsuta with some targets related to type 2 diabetes
... ID-4IXC), pyruvate dehydrogenase kinase (PDB ID-4MP2), peroxisome proliferator-activated receptor- gamma (PDB ID-3DZY), glycogen synthase kinase-3 (PDB ID-3F7Z),11β-Hydroxysteroid ...
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(HR=1.81, 95% CI: 1.42-2.31, P<0.001 ). Moreover, PDK1 was related to T grade (OR=1.72, 95% CI: 1.27-2.31, P<0.001 Conclusion: The present meta-analysis showed that high PDK1 expression predicts poor prognosis and T
... that pyruvate dehydrogenase kinase 1 (PDK1) is dysregu- lated in various tumors and that PDK1 overexpression is associated with survival and clinicopathological features in patients with ...
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Warburg effect hypothesis in autism Spectrum disorders
... (Glut), pyruvate kinase M2 (PKM2), pyruvate dehydrogenase kinase 1(PDK1), monocarboxylate lactate transporter 1 (MCT-1), lactate dehydrogenase kinase-A (LDH-A) and ...
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Pyruvate Dehydrogenase Complex Activity in Normal and Deficient Fibroblasts
... Pyruvate dehydrogenase complex (PDC) activity in human skin fibroblasts appears to be regulated by a phosphorylation-dephosphorylation mechanism, as is the case with other animal ...of pyruvate ...
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Amyloid beta resistance and the Warburg effect: Re-examining Alzheimer's disease
... of pyruvate dehydrogenase kinase 1 (PDK1) (Kim et ...inhibits pyruvate dehydrogenase (PDH), an enzyme responsible for the conversion of pyruvate to acetyl-CoA (Papandreou et ...
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Cilostazol Enhances Oxidative Glucose Metabolism in Both Neurons and Astroglia without Increasing Ros Production
... The direct mechanism of the cAMP-dependent en- hancement of PDH activity was not completely eluci- dated in the present study. PKA is a candidate enzyme that might regulate PDH activity because PKA phos- phorylates ...
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The dilemma for lipid productivity in green microalgae: importance of substrate provision in improving oil yield without sacrificing growth
... of pyruvate in the plastids, rather than acyl assembly into TAGs, was the major contributing factor responsible for its oleagen- icity [65], as transcript levels of enzymes involved in plas- tidial carbon ...
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Central Hypoventilation Syndrome in Pyruvate Dehydrogenase Complex Deficiency
... 74:1034-1040; central hypoventilation syndrome, doxap- ram, almitrine, lactic acidosis, pyruvate dehydrogenase complex.. In recent years, more than 50 patients have been reported with va[r] ...
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Pyruvate-Phosphate Dikinase of Oxymonads and Parabasalia and the Evolution of Pyrophosphate-Dependent Glycolysis in Anaerobic Eukaryotes
... PPDK catalyzes the interconversion between phosphoenol- pyruvate (PEP) and pyruvate. Unlike the reaction catalyzed by PK, this reaction has a small ⌬ G and is reversible, so it can proceed either in the ...
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Phosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells
... The pyruvate dehydrogenase complex (PDC) is an important gatekeeper enzyme connecting glycolysis to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation ...the pyruvate ...
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The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
... The acetyl-CoA and NADH produced by fatty acid oxidation stimulated PDK activity in skeletal muscle [11]. There was also a selective induction of forkhead box O1 (FoxO1) and forkhead box O3 (FoxO3) tran- scripts in ...
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Insulin like growth factor (IGF) signalling and genome wide transcriptional regulation in fast muscle of zebrafish following a single satiating meal
... Growth hormone is synthesized, stored and secreted by specialized cells in the anterior pituitary and plays a central role in controlling feeding behaviour, cell growth, osmoregulation and reproduction in teleosts ...
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Trojans in Wireless Sensor Networks
... supplied, glucose is metabolized through glycolysis and followed by TCA cycle in mitochondria. Glucose is converted to pyruvate and lactate when oxygen in the cell environment is low. Cancer cells, however, ...
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Evaluation of tumor M2 pyruvate kinase (Tumor M2 PK) as a biomarker for pancreatic cancer
... of pyruvate kinase [1 – ...M2- pyruvate kinase as a diagnostic test for pancreatic cancer ...M2-pyruvate kinase had an area under the curve (AUC) of ...
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Pyruvate kinase and the "high ATP syndrome"
... The pyruvate kinase activity was specifically increased (about twice the normal ...the pyruvate kinase activity was found to be increased in all Percoll ...fractions. Pyruvate ...
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