Quaternary Structure
A New Quaternary Structure Epitope on Dengue Virus Serotype 2 Is the Target of Durable Type Specific Neutralizing Antibodies
... and structure-guided design of a chimeric DENV, here we de- scribe the major site on the DENV2 envelope (E) protein targeted by neutralizing ...a quaternary structure ...
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The Role of Collagen Quaternary Structure in the Platelet:Collagen Interaction
... queternary structure is required for the platelet: collagen interaction. Quaternary structure refers to the assembly of collagen monomers (tropocollagen) into polymers (native-type ...
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Immunogenicity of a Prefusion HIV-1 Envelope Trimer in Complex with a Quaternary-Structure-Specific Antibody
... The HIV-1 envelope trimer (Env) is the target of broadly neutralizing antibodies and is being explored as a vaccine candidate to elicit protective antibodies. One of the most promising antigenic and structural mimics of ...
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Quaternary structure of the specific p53 DNA complex reveals the mechanism of p53 mutant dominance
... Figure 2. 3D reconstruction of the p53–DNA complex. (A) Side and top views of the p53–DNA complex. (B) Superimposition of the DNA-free p53 map (gold) on the p53–DNA complex map (blue–grey). The two maps were compared in ...
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Human antibody response to Zika targets type-specific quaternary structure epitopes
... protein quaternary epitopes displayed on the virion but not on recombinantly expressed monomeric E protein ...or quaternary epitopes on E ...against quaternary epitopes, plasma from each of the 4 ...
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Disulfide Bonds and the Quaternary Structure of Factor VIII/von Willebrand Factor
... Although the separation of Factor VIII activity from VWF by gel filtration in 0.25 M CaCl2 is not inconsistent with the hypothesis that two different, noncovalently associated proteins m[r] ...
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Bacteriophage quaternary structure studied with laser light diffraction of periodic electron microscopic images
... A topological analysis of capsid morphology has been presented by Caspar and Klug 1962, This geometric consider ation of virus structure was based on an appraisal of the problem in clos[r] ...
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Quaternary structure of influenza virus hemagglutinin after acid treatment.
... 833 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Hemagglutinin HA, a trimeric spike glycoprotein of influenza virus, mediates fusion between the viral envelope and t[r] ...
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Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs
... BRET assays in cells expressing fusion proteins containing hemi-Rluc8 and hemi-Venus moieties fused to adenosine receptors or containing the ghrelin GHS1a receptor instead of one of the [r] ...
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Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1
... other quaternary-specific an- tibodies. Details of the 2909 structure and functional data from antibody chimeras clarified the relationship of 2909 to other members of the quaternary-specific class ...
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Structure of Parvovirus B19 Decorated by Fabs from a Human Antibody
... The quaternary structure epitope on B19 consists of residues from three VP2 ...a quaternary epitope formed by three neighboring VP2 proteins, which are colored in blue, green, and ...
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PCA and SOM based Dimension Reduction Techniques for Quaternary Protein Structure Prediction
... Protein structure prediction leads to the discovery of different important drugs, enzymes ...the structure of a protein in lesser time and with reduced ...the structure of a protein, as it possesses ...
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Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket
... the structure of the capsid, determined by molecular replacement, we were surprised to find that the quater- nary structure of the HAP18-bound capsid was unlike that of the HAP1-capsid complex and instead ...
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Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus
... The quaternary structure and substrate preferences of MERS-CoV PLpro were determined and compared to those of severe acute respiratory syndrome coronavirus (SARS-CoV) PLpro, revealing prominent differences ...
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Caspase and granzyme regulated events in apoptosis and inflammation
... Figure 5.10 Stabilization of caspase-1 by kosmotropic salts or high molar substrate concentration Figure 5.11 Caspase-1 inactivation is associated with loss of quaternary structure Figur[r] ...
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Combining nano-physical and computational investigations to understand the nature of “aging” in dermal collagen
... Fibrillar structure was fragmented with no overall cohesion; the scaf- fold was porous with a cluster of interstitial gaps appearing in between the fibril ...the quaternary structure of collagen are ...
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Cell adhesion in vascular biology New insights into integrin ligand interaction
... consistent with the idea that activation leads to a hinge motion of the I-domain that unmasks potential ligand binding sites on the propeller. This motion would also allow shape shifting within the I-domain that allows ...
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Aggregation Kinetics for Monoclonal Antibody Products - Volume 5 Number 5 (Oct. 2014) - IJCEA
... Fig. 1. Schematic illustration of common aggregation mechanisms [2]. The extent of aggregation depends on many factors which can be broadly classified as intrinsic (primary, secondary, tertiary or quaternary ...
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PubMedCentral-PMC5123051.pdf
... complex structure shows that the antibody binds to E proteins residues at the intra-dimer interface, and the virus quaternary structure-dependent inter-dimer and inter-raft ...raft structure, ...
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Molecular docking as a popular tool in drug design, an in silico travel
... High-throughput X-ray crystallography of a target alone or in complex with small molecules has significantly grown these last years. With the development of increasingly more sophisticated computational tools, SBDD is ...
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