RAD51 protein
Rad51 Protein from the Thermotolerant Yeast Pichia angusta as a Typical but Thermodependent Member of the Rad51 Family
... of Rad51-related proteins from three yeast species and one Rad51 protein from a ...of Rad51 proteins used for the alignment represents the obvious differ- ence in recombination DNA repair ...
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RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy
... of RAD51 protein expression ...enhanced RAD51 protein instability, sensitizing cells to DNA damage ...reduced RAD51 expression observed with high dose p38 inhibitor, however, this was ...
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Glu-108 in Saccharomyces cerevisiae Rad51 Is Critical for DNA Damage-Induced Nuclear Function
... The protein sequence of Rad51 with entry P25454 and the ATP-dependent molecular chaperone yHsp90 (Hsp82) with entry P02829 of Saccharomyces cerevisiae (strain ATCC 204508/S288c) are publicly available from ...
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Homologous recombination: from model organisms to human disease
... lacking Rad51-paralog genes are not viable ...assisting Rad51 in homologous recombination has shifted from Rad52 in yeast towards the Rad51 paralogs in ...these Rad51-accessory proteins. The ...
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Genetic instability in the RAD51 and BRCA1 regions in breast cancer
... The RAD51 gene located on chromosome ...human RAD51 gene encodes a 339- amino acid protein with a molecular weight of 37 kDa, a homologue of the RecA protein of Escherichia coli and ...
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EuropePMC-PMC5541366.pdf
... and Rad51, with E7 expression alone being sufficient for this increase (Chappell et ...and Rad51 mRNA levels in uninfected HFKs, as well as HFKs containing wild-type HPV31 genomes, or E7 ΔLHCYE mutant ...
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Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer
... of RAD51 protein expression in irradiated HT29 ...of RAD51 protein expression from 3 independent experiments normalized to ...(C) RAD51 was overexpressed using a RAD51 expressing ...
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PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells
... UHRF1 protein interacts with HDAC proteins in the epigenetic repression complex ...histone protein H3 ...BRCA1 protein levels to different extents, and that co-treatment with SAHA and veliparib ...
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Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery
... and Rad51 to repair the replication-associated DSB through homologous recombination ...and Rad51 protein levels, formation of nuclear foci of all three proteins and recovery of stalled or collapsed ...
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Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein
... 4: Rad51 protein level detected by reverse phase protein microarray in different breast cancer cell ...for RAD51 and ...extracted protein from cell lines and probed with the antibodies ...
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Biochemical characterisation of the human RAD51 recombinase
... The cell paste was resuspended in 100 ml HI buffer supplem ented with PMSF (0.5 m g/m l). All subsequent steps were carried out at 4°C. Cells were lysed by one freeze-thaw cycle and 3 bursts (1 minute) in a H eat Systems ...
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Rad51 ATP binding but not hydrolysis is required to recruit Rad10 in synthesis dependent strand annealing sites in S cerevisiae
... Repressor Protein bind- ing site (224 × ...Fluorescent Protein (TetR-RFP) is constitutively expressed from an intergenic region on chromosome VII ...
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Exploring the Association between Network, Cognitive, Structural Social Capital and the Risk of Clinical Depression in Taiwan
... Replication protein A (RPA) binds to the single-stranded DNA (ssDNA) to keep the strands from re-annealing to one another as the topoisomerase-helicase complex and polymerases act in concert to unwind the parental ...
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The sep1 mutant of Saccharomyces cerevisiae arrests in pachytene and is deficient in meiotic recombination.
... Because DMCl and RAD51 are thought to encode redundant functions (BISHOP et al. Both the RAD51 gene and the SEPl gene are ex- pressed during vegetative growth; t[r] ...
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Five RecA-like Proteins of Schizosaccharomyces pombe Are Involved in Meiotic Recombination
... W. D. Heyer et al., 1999 A new recombinational DNA repair Shinohara, A., S. Gasior, T. Ogawa, N. Kleckner and D. K. Bishop, gene from Schizosaccharomyces pombe with homology to Escherichia 1997 Saccharomyces cerevisiae ...
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Bower_unc_0153D_14904.pdf
... (His)6-UP1 protein was affinity purified using ...The protein was quantified by measurement of 280 nm absorbance; aliquoted; flash frozen in liquid nitrogen; and stored at -80°C until ...
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Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins
... and Rad51 in nuclear foci based on the idea that these candidates may represent a typical course of the DSB repair cascade ...and Rad51. Rad51 is the most downstream of these four pro- teins and is ...
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<p>Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair</p>
... family protein and HDAC inhibition synergistically inhibits chondrosarcoma cell growth, induces DNA damage, and subsequent cell apopto- ...the RAD51-related HR repair ...
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RAD51 Is Required for Propagation of the Germinal Nucleus in Tetrahymena thermophila
... of RAD51 form into a highly amplified palindrome during the expression from their macronuclear anlagen during ex- course of macronuclear development (Butler et ...a rad51 ⫺ ⫻ Marsh, E. C. Cole and D. P. ...
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Dynamin impacts homology directed repair and breast cancer response to chemotherapy
... some Rad51, suggesting that Rad51 recruitment to DSBs was reduced rather than ...of Rad51 foci assembly, foci are formed from the available nuclear pool of Rad51 ...of Rad51 (30) and ...
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