Radical Cure
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group
... The perceived need for G6PD testing therefore depends on a balance of the population-level risk of drug induced haemolysis and the benefits of achieving radical cure. The healthcare priority for managing a ...
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Population structure and spatio temporal transmission dynamics of Plasmodium vivax after radical cure treatment in a rural village of the Peruvian Amazon
... Data were double entered and cleaned in Excel (Micro- soft, USA) and then analysed with SPSS v.16 (SPSS Inc, Chicago, IL, USA). A P. vivax recurrence was defined as any symptomatic (i e, fever: axillary temperature ...
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Randomized trial of primaquine hypnozoitocidal efficacy when administered with artemisinin-combined blood schizontocides for radical cure of Plasmodium vivax in Indonesia
... Primary endpoint was incidence density (events/person- year) of first relapse by P. vivax in the year following radical cure. Patients reaching that endpoint contributed time at risk up to that event or ...
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A pilot randomized controlled trial to compare the effectiveness of two 14 day primaquine regimens for the radical cure of vivax malaria in South India
... An estimated 2.5 billion people live in areas where Plas- modium vivax infection is endemic [1]. India, Ethiopia, Indonesia and Pakistan account for > 80% of the world’s vivax malaria [2]. Malaria remains a major ...
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Primaquine radical cure of Plasmodium vivax: a critical review of the literature
... The World Health Organization (WHO) guidelines for the radical cure of vivax malaria currently recommends the use of a daily dose of 0.25 mg/kg/day (3.5 mg/kg total dose) primaquine taken with food once ...
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Improving the radical cure of vivax malaria (IMPROV): a study protocol for a multicentre randomised, placebo controlled comparison of short and long course primaquine regimens
... Background: Plasmodium vivax malaria is a major cause of morbidity and recognised as an important contributor to mortality in some endemic areas. The current recommended treatment regimen for the radical ...
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The challenges of introducing routine G6PD testing into radical cure: a workshop report
... for radical cure in G6PD normal individuals [8] should be monitored for haemolysis during the first 7 days of treatment [42]; alternatively they can be treated with the 8 week 45 mg primaquine/week regimen ...
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A radical cure for Italy’s banking problems: A combination of good banks and soft bail-in. CEPS Policy Brief No. 351 / December 2016
... Taking care of the NPLs in the distressed banks would require a combination of a modest amount €5 billion of ‘hard’ bail-in of some subordinated instruments, whose holders would lose eve[r] ...
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The clinical and public health problem of relapse despite primaquine therapy: case review of repeated relapses of Plasmodium vivax acquired in Papua New Guinea
... Primaquine toxicity in glucose-6-phosphate dehydro- genase (G6PD)-deficient patients imposes several im- portant obstacles to achieving radical cure. Adherence to 14 days of daily dosing may be unlikely ...
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Methods for the field evaluation of quantitative G6PD diagnostics: a review
... Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at risk of severe haemolysis following the administration of 8-aminoquinoline compounds. Primaquine is the only widely available 8-aminoquinoline ...
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ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITIES OF DOLICHANDRONE ATROVIRENS USING VARIOUS IN VITRO ASSAY MODELS
... There is an increased interest in natural antioxidants present in medicinal and dietary plants, which might help to prevent oxidative damage (Silva et al., 2005). Dolichandrone atrovirens is a deciduous tree, belongs to ...
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Radical Republicans: How Radical Were They?
... Republican Party was written in 1910 and analyzes how the Republicans were not trying to emancipate slaves, they merely wanted to seize control of the South by using the freedmen to do so. 1 Dunning emphasizes how ...
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Synergies, tensions and challenges in HIV prevention, treatment and cure research: exploratory conversations with HIV experts in South Africa
... HIV cure re- search, we also asked participants about specific research ethics issues related to HIV cure ...to cure re- search, were issues that are also applicable to HIV and medical research more ...
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Is it necessary to cure prostate cancer when it is possible? (Understanding the role of prostate inflammation resolution to prostate cancer evolution)
... with radical prostatectomy, cryotherapy, or radiation therapy generally follows the initial diagnosis of prostate cancer, particularly when men have at least 10 additional years of life ...
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A cure for AIDS: a matter of timing?
... thus hinting that a complete eradication may have been achieved [61,63]. Despite the enormous excitement gener- ated by the news of this cure, the scarcity of HLA-DR- compatible CCR5 Δ32 donors makes it very ...
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Efficacy of Thermotherapy to Treat Cutaneous Leishmaniasis Caused by Leishmania tropica in Kabul, Afghanistan: A Randomized, Controlled Trial
... experienced cure, the cure rate among patients treated with intralesional SSG would be sig- nificantly larger than that for patients treated with intramus- cular SSG or with thermotherapy; the cure ...
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The psychology of “cure” - unique challenges to consent processes in HIV cure research in South Africa
... “ cure ” intervention study to assess impact would require an extended period of follow-up and monitoring to en- sure that the “cure” had worked and that all the body’s reservoirs were cleared of ...of ...
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Posterior intravaginal slingplasty for vault and uterovaginal prolapse: an initial experience
... We also compared the cure rates between the two groups of vault and uterovaginal prolapse (Table 4). The difference in the median values between the two groups is not great enough to exclude the possibility that ...
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How to Make Impressions for Different Implant...
... 9 compared polyether impressions, splinted with autopolymerizing acrylic resin, dual-cure acrylic resin and impression plaster and reported that dual-cure resin spli[r] ...
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STUDENT UNREST- CAUSES AND CURE
... undesirable activities among students gradually peter out. But it would be wrong to bank upon this seasonal cure. Since what, because of the fear of the examination, has receded in the dormant regions of the mind ...
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