RANK Ligand
Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget’s disease of bone
... compared RANK ligand (RANKL) mRNA expression in a marrow stromal cell line developed from a pagetic lesion (PSV10) with that in a normal stromal cell line (Saka), and expression in marrow samples from ...
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A TNF receptor loop peptide mimic blocks RANK ligand–induced signaling, bone resorption, and bone loss
... critical ligand contact site on the TNFR is partly conserved in ...to RANK ligand ...of RANK-dependent signaling in RAW ...TNFR ligand contact site blocks bone resorption by interfering ...
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A water extract of Malva verticillata seeds suppresses osteoclastogenesis and bone resorption stimulated by RANK ligand
... (RANK) ligand signaling, and the expression of c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) were investigated by western blot ...
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Denosumab, a RANK ligand inhibitor, for the management of bone loss in cancer patients
... Abstract: Bone loss is a common side effect of cancer treatments, especially antihormonal treatments used in the treatment of breast and prostate cancer. Denosumab is a monoclonal antibody given subcutaneously that ...
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RANK ligand (RANKL) expression in young breast cancer patients and during pregnancy
... both RANK and RANKL ...in RANK staining intensity and fraction of positive cells was observed in both tumors and normal ...(a) RANK IHC of a breast tumor sample with relatively low expression ...
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Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
... lifespan of osteoclasts by decreasing apoptosis. In bone marrow, RANKL is expressed on the surfaces of MSCs of the osteoblast lineage (13), T lymphocytes (6), and B lym- phocytes (14). Cell-to-cell contact allows RANKL ...
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TNF α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
... TNF-α, like most osteoclastogenic agents, exerts its effect via receptors on stromal or osteoblastic cells. Hence, determining if the cytokine also directly pro- motes the differentiation of osteoclast precursors ...
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Soluble Rank Ligand Produced by Myeloma Cells Causes Generalised Bone Loss in Multiple Myeloma
... In conclusion, using mouse models of myeloma we have been able to demonstrate that myeloma is associated with both focal osteolytic bone disease and osteoporosis, and this is associated with increased serum ...
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IGF I increases markers of osteoblastic activity and reduces bone resorption via osteoprotegerin and RANK ligand
... The aim of the present work was to study the effect of low doses of IGF-I on bone in this animal model, by determining the following parameters: 1) bone weight, morphometry, densitometry and cortical thickness in ...
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Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli
... by RANK activa- tion is important to prevent the overactivation of TLR sig- nalling in microglial ...the RANK signalling (including the downregulation of RANK expression; ...
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Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
... and RANK ligand (RANKL) were originally shown to be essential for osteoclastogenesis, lymph node development, and forma- tion of lactating mammary glands during ...of RANK and RANKL in various solid ...
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Receptor activator of nuclear factor-kappa B ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells
... (RANK)/ RANK ligand (RANKL)/osteoprotegerin (OPG) are the key regulators of bone ...of RANK in several bone-associated ...functional RANK expression both in a mouse and several human ...
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Giant Cell Tumor Developing in Paget’s Disease of Bone: A Case Report with Review of Literature
... GCT developing in the background of Paget’s disease is a rare occurrence which is commonly seen in polyostotic PDB. GCT-PDB is associated with more severe manifestations of the disease with reduced life expectancy. ...
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Combining RANK/RANKL and ERBB 2 targeting as a novel strategy in ERBB 2 positive breast carcinomas
... between RANK receptor and ERBB family members. RANK dimerization with ERBB2 seems to play a fundamental role in the progress of ERBB2-positive breast ...with RANK, in NF-κB signaling, a key ...
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ES Rank: evolution strategy learning to rank approach
... to Rank (LTR) is one of the current problems in Information Retrieval (IR) that attracts the attention from ...ES- Rank achieves the overall best ...
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Data-driven Rank Breaking for Efficient Rank Aggregation
... for rank aggregation that can take such diverse forms of ordinal data into ...to rank from pairwise comparisons, ...full rank- breaking defined explicitly in (1), where all pairwise comparisons are ...
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Answering questions by learning to rank Learning to rank by answering questions
... In this paper, we highlighted an important problem with many of the current approaches developed for multiple-choice question answering tasks. To overcome the poor performance of the IR engines used to retrieve ...
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Tests of rank
... the rank of a matrix that is unobserved but for which a root-T consistent ~RTC! estimator is available + Gill and Lewbel ~1992! were the first authors to consider this problem + However , their solution based on ...
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New rank detection methods for reduced rank MIMO systems
... reduced rank. Reliable detection of the channel rank is essential in achieving the significant gain provided by MIMO ...channel rank detection assume a static channel model, so the proposed methods ...
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RANKing the importance of measles virus in Paget’s disease
... and RANK-L give rise to numerous functional osteoclasts (7), and this process can be blocked in a dose-dependent manner by OPG ...of RANK-L into mice results in a rapid (< 1 day) increase in serum ...
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