Rapid method development in hydrophilic interaction liquid
Quantitative structure retention relationships for rapid method development in hydrophilic interaction liquid chromatography of pharmaceutical compounds
... QSRR-DoE method is capable of using the chemical structures of new analytes to predict retention times under a new HILIC condition with an acceptably low ...
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Hydrophilic interaction liquid chromatography: An update
... methodology which is common to most samples and does not require analytical development, it suffers from spectral overlap and low sensitivity. Thus, mass spectrometry, which is considerably more sensitive, coupled ...
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Optimization of hydrophilic interaction liquid chromatographic method for simultaneous determination of cetylpyridinium chloride and benzocaine in lozenges
... new Hydrophilic Interaction Liquid Chromatography (HILIC) method was developed for simulta- neous determination of cetylpyridinium chloride and benzocaine as active substances in ...lozenges. ...
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HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY (HILIC) AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS
... HILIC method is better to use with ESI-MS. It is because highly organic mobile phase result in desolvation and hence lower detection limits. For example, retention of nicotine and continine by RP chromatography ...
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Quantitative structure retention relationships for rapid method development in reversed phase liquid chromatography
... ' values was used as the gold standard. An overview of the ranking and probability level can be seen from Figure 4.36. The LSDI and LCT approach were ranked closest to the gold standard, which demonstrated that these two ...
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Development and validation of a rapid liquid chromatographic method for the analysis of Lansoprazole and its related production impurities
... RESULTS AND DISCUSSION Main objective of this analytical method development was to separate Lansoprazole from Impurity A, Impurity B and Impurity C. Different Mobile phases and different stationary phases ...
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Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed phase liquid chromatography
... 4. Conclusions Significant differences in both the reduced and non-reduced axial diffusion behaviour of solutes in the RP and HILIC modes were observed on columns made from the same silica. These differences were ...
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Title: Determination of thiopurine S-methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry
... identification of 6-MMP as well as 6-MP, however, some partial overlapping could not be avoided as it can be seen in Fig. 1. The presence of such interference makes the evaluation of the obtained data difficult and can ...
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DNA hydroxymethylation age of human blood determined by capillary hydrophilic-interaction liquid chromatography/mass spectrometry
... Several studies have investigated the genomic methyla- tion maps of CpG islands in individuals of increasing age. Bocklandt et al. [37] identifies 88 sites in 80 genes for which the degree of DNA cytosine methylation is ...
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A study of column equilibration time in hydrophilic interaction chromatography
... in hydrophilic interaction liquid chromatography (HILIC) was compared using the mobile phase disturbance method, column efficiency measurements and retention time ...
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Development and validation of liquid chromatogrphic method for Trazodone hydrochloride
... isocratic, rapid and sensitive high performance liquid chromatographic method has been developed for quantitative determination of Trazodone Hydrochloride and its three process related ...The ...
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DEVELOPMENT AND VALIDATION OF RAPID STABILITY INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF LINAGLIPTIN AND EMPAGLIFLOZIN IN PURE AND DOSAGE FORMS
... this method represents a strong reduction of the analysis time and it is considered as a stability-indicating ...proposed method ensured a precise and accurate determination of LNG and EMP in tablet ...
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Development of a Rapid and Efficient Liquid Chromatography Method for Determination of Gibberellin A4 in Plant Tissue, with Solid Phase Extraction for Purification and Quantification
... About 1 gr. of each sample was frozen with liquid nitrogen and macerated with a pestle until a fine powder was obtained. 50 mg of powder were accurately weighed with a calibration analytical balance and placed in ...
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Development of a High Throughput (HT) Raman Spectroscopy Method for Rapid Screening of Liquid Blood Plasma From Prostate Cancer Patients
... studying molecular composition and the structure of macromolecules, either in their isolated form 9 or within complex biological systems such as cells and tissues 10 . It can quantitatively or qualitatively analyse ...
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A rapid and sensitive method for determination of carotenoids in plant tissues by high performance liquid chromatography
... pressure liquid chromatog- raphy (HPLC) and combination of HPLC with mass spectrometry including ...used method for identification and quantification of carotenoids utilizes HPLC combined with UV–vis ab- ...
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Rapid and sensitive liquid chromatographic method for determination of paclitaxel from parenteral formulation and nanoparticles
... Formulation Development and Pharmacokinetics Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Pilani-333 031, India Kollipara, et ...RP-HPLC Method for Paclitaxel Estimation A simple ...
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Combined hydrophilic interaction liquid chromatography-scanning field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry for untargeted metabolomics
... comprehensive liquid chromatography-mass spectrometry workflow incorporating a fast-scanning miniaturised high- field asymmetric waveform ion mobility spectrometry separation (LC-FAIMS-MS) is applied to the ...
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Characterization of Red Wine Proanthocyanidins Using a Putative Proanthocyanidin Database, Amide Hydrophilic Interaction Liquid Chromatography (HILIC), and Time-of-Flight Mass Spectrometry.
... novel method for characterizing wine proanthocyanidins using a theoretical database comprised of the chemical formula and exact mass of 996 ...performance liquid chromatography (UHLPC) with a ...
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Development of a rapid and inexpensive method to reveal natural antisense transcripts
... sible interaction between the two forms (see Figure 3), we hypothesised that interactions between sense and antisense OeSLG transcripts occur along the entire length of the sequences, producing one or two bulges ...
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Development of a 3D Code for the Analysis of Fluid-Structure Interaction in the Liquid Storage Tank
... (PCBFC) method, a 3D code was developed for the analysis of free surface flow, which effectiveness was confirmed by the seismic response experiment of liquid sloshing in the annular region formed by coaxial ...
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