Ras GTPase
RAS GTPase AS THE DRUG TARGET FOR ANTI CANCER DESIGNING OF DRUG FROM TEMPLATE
... RESULTS AND DISCUSSIONS: Eight ras GTPase complexes, 1K8R, 2KE5, 2UZI, 2VH5, 4GZL, 4GZM, 3GFT and 3TSO have been identified from the repository. By sequence analysis, the properties such as instability ...
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Ras GTPase-Activating Protein Regulation of Actin Cytoskeleton and Hyphal Polarity in Aspergillus nidulans
... a Ras GTPase-activating ...of Ras signaling at the plasma membrane of these tips is involved in the polarization of the actin cytoskeleton that is required for hyphal growth and, possibly, for ...
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Ras GTPase-Activating Protein Gap1 of the Homobasidiomycete Schizophyllum commune Regulates Hyphal Growth Orientation and Sexual Development
... a Ras GTPase-activating protein. A cDNA fragment encoding a Ras GTPase-activating protein, gap1, had been identified previously in a screen for differentially expressed genes in B-regulated ...
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A Role for the Rap GTPase YlRsr1 in Cellular Morphogenesis and the Involvement of YlRsr1 and the Ras GTPase YlRas2 in Bud Site Selection in the Dimorphic Yeast Yarrowia lipolytica
... Rap GTPase Rsr1 of ...the Ras GTPase YlRas2 caused ...the Ras GTPase YlRas2 is also involved in the control of bud site selection, as Ylras2 ⌬ cells were severely impaired in bipolar ...
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Systems level expression correlation of Ras GTPase regulators
... the RAS GTPase subfamily and their regulatory GEF and GAP proteins using a large set of published data for normal tissues from a wide range of species, human cancer tissues and human cell ...of RAS ...
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Detection of Related Solvent Positions and Multiple Solvent Crystal Structures of Trypsin, Chymotrypsin, and Ras-GTPase.
... of Ras, where there is typically weak electron density for switch II residues when not stabilized by crystal ...of Ras along with the two switch ...in Ras oncogenesis and result in disruption of the ...
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Tfs1p, a Member of the PEBP Family, Inhibits the Ira2p but Not the Ira1p Ras GTPase-Activating Protein in Saccharomyces cerevisiae
... proteins: GTPase-activating proteins (GAPs) inhibit Ras proteins, whereas guanine exchange factors activate ...a Ras GAP, Ira2p, in Saccharomyces ...of Ras demonstrate that Tfs1p interacts ...
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Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae
... GTPase from amino acids 193–401 and a RASGAP C-terminal motif from amino acids 580–699. There are four putative GapA-encoding genes in M. oryzae, and phylogenetic analy- sis (Figure S1) revealed potential SMO1 ...
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Hepatitis C Virus Co-Opts Ras-GTPase-Activating Protein-Binding Protein 1 for Its Genome Replication
... Huh7 cells harboring the S2204I bsd HCV Con1 bicistronic replicon 11, a pHCVrep1b/BB7 HCV subgenomic replicon 5 derivative that expresses blas- 6996 Downloaded from http://jvi.asm.org/ o[r] ...
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Ras GTPase like protein MglA, a controller of bacterial social motility in Myxobacteria, has evolved to control bacterial predation by Bdellovibrio
... a Ras-like GTPase, MglA, which polarises the cell during gliding [6,7], and GTPase- activating protein (GAP) protein MglB, which activates the GTPase activity of MglA to inhibit cellular ...
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Hyphal Guidance and Invasive Growth in Candida albicans Require the Ras-Like GTPase Rsr1p and Its GTPase-Activating Protein Bud2p
... the GTPase-activating protein (GAP) for ...Rsr1p GTPase, the almost identical phenotypes of the rsr1/rsr1 and bud2/bud2 strains suggest that cycling of Rsr1p between GDP- and GTP- bound states is required ...
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Effects of lovastatin on breast cancer cells: a proteo metabonomic study
... Small GTPase-proteins are frequently discussed tar- gets of statins ...of Ras-GTPase activating bind- ing protein G3BP1 (down-regulation of its unmodified and its active phospho form) and CDC42 ...
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The Rab GTPase family
... endosomal GTPase Rab5a has several different effectors, and this is probably true for other Rabs as well ...Rab GTPase may be capable of regulating several molecular events at a restricted membrane ...
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System Wide Characterization of MoArf GTPase Family Proteins and Adaptor Protein MoGga1 Involved in the Development and Pathogenicity of Magnaporthe oryzae
... Human HsGga proteins must interact with HsArf proteins for proper localization and function, whereas these interactions play a minor role in the Golgi localization and in the function of ScGga proteins in S. cerevisiae ...
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WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
... destabilizes RAS in HCC [19], so we examined whether Wdr76 regulates Ras stability in the small intes- ...restricts Ras abundance by regu- lating the stability of the Ras ...of Ras ...
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Quantitative Analysis of Ras Oncogene Isoforms Using Decision Tree and Support Vector Machine
... regarding Ras gene studies; current studies on Ras isoforms have not succeeded in complete classification ...each Ras oncogenes in the various cell lineages and tissues where they are all present and ...
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A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis
... Abbreviations: AHA2, Arabidopsis H +-ATPase 2; ARF GTPase, ADP-ribosylation factor GTPase; AtHKT1, Arabidopsis thaliana high affinity K+ transporter 1; B, boron; BFA, brefeldin A; BHT, b[r] ...
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REVIEW OF MAKARDHWAJA RASA IN INFERTILITY .......
... Objective: to review the impor- and methods: literary study is done Sushrut Samhita, Bhaishajya Ratnavali, Ras Ratna Samucchaya, Ras Tarangini, Ras Prakasha Sudhakar, Rasamrita, Rasendra Sar ...
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Performance of Recycled Asphalt Shingles in Hot Mix Asphalt
... of RAS on the performance of ...of RAS materials and lack of past experiences led to the creation of Transportation Pooled Fund (TPF) Program ...of RAS that include RAS grind size, RAS ...
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Pathogenic Escherichia coli Hijacks GTPase Activated p21 Activated Kinase for Actin Pedestal Formation
... EspG is one such effector protein (15), delivered by both EPEC and EHEC (EPEC also encodes a second EspG homologue, EspG2, which is 42% identical and 62% similar to EspG [16]). Functions reported for EspG include ...
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