ras GTPase-Activating Proteins
Hepatitis C Virus Co-Opts Ras-GTPase-Activating Protein-Binding Protein 1 for Its Genome Replication
... G3BP1 interaction with the HCV minus-strand RNA 5 ⴕ ter- minal region [5 ⴕ ( ⴚ )TR] requires the RRM motif. To deter- mine whether G3BP1 directly binds to HCV 5 ⬘ ( ⫺ )TR RNA, FIG. 1. Interactions between G3BP1 and HCV ...
9
Tfs1p, a Member of the PEBP Family, Inhibits the Ira2p but Not the Ira1p Ras GTPase-Activating Protein in Saccharomyces cerevisiae
... of Ras with an arginine (the finger) localized at the tip of a loop (the finger loop) joining two ␣-helices, thus stabilizing the transition state of the GTPase reaction and playing a crucial role in ...
12
Ras GTPase-Activating Protein Regulation of Actin Cytoskeleton and Hyphal Polarity in Aspergillus nidulans
... nidulans, a threshold of RasA activity is required for the initi- ation of conidiophore development. This activity must subse- quently decrease for progression of aerial hyphae through the developmental pathway (74). In ...
13
RalA, a GTPase targeted by miR‑181a, promotes transformation and progression by activating the Ras‑related signaling pathway in chronic myelogenous leukemia
... pro‑metastatic proteins, downstream of RalA, were reduced by RalA inhibition in K562 ...are ras downstream signaling ...that Ras activation of RalA leads to engagement of multiple effector pathways ...
13
Hyphal Guidance and Invasive Growth in Candida albicans Require the Ras-Like GTPase Rsr1p and Its GTPase-Activating Protein Bud2p
... Rho-type GTPase Cdc42p, cortical actin patches, and the polarisome protein Spa2p all polarize to the site of active growth (29, ...cerevisiae Ras-like GTPase Rsr1p is important for determining the ...
14
Biochemical characterisation of rho/rac GTPases and their GTPase activating proteins in humans and Dictyostelium discoideum
... the GTPase activity and interactions with target proteins have been ...For ras, oncogenic mutants have been found where the most common amino acid substitutions occur in codons 12, 13, or ...
240
Ras GTPase-Activating Protein Gap1 of the Homobasidiomycete Schizophyllum commune Regulates Hyphal Growth Orientation and Sexual Development
... a Ras GTPase-activating ...a Ras GTPase-activating protein, gap1, had been identified previously in a screen for differentially expressed genes in B-regulated development of ...
13
Specific Rab GTPase activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
... Rab GTPase- activating proteins (GAPs) that interfere with this ...of Ras GAPs (Ahmadian et ...domain–containing proteins, the identifi cation of specifi c Rab–Rab GAP pairs is not a ...
12
Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae
... Ras proteins are low-molecular weight monomeric G-proteins, which localize to the plasma membrane (Wennerberg et ...1993). Ras proteins have intrinsic GTPase and GDP/GTP exchange ...
17
Effects of lovastatin on breast cancer cells: a proteo metabonomic study
... Small GTPase-proteins are frequently discussed tar- gets of statins ...of Ras-GTPase activating bind- ing protein G3BP1 (down-regulation of its unmodified and its active phospho form) ...
20
Haas, Alexander (2008): Regulation of endocytosis and secretion by Rab GTPase activating proteins. Dissertation, LMU München: Fakultät für Biologie
... 40 proteins containing a TBC domain, some of which also give rise to splicing ...domain proteins the arginine is shifted, in others the arginine is replaced by other amino ...the Ras super-family not ...
168
GTPase-Activating Proteins for Cdc42
... the Ras superfamily of GTPases, which act as molecular switches and regulate many cellular processes (1, ...of proteins: guanine nucleotide exchange factors (GEFs) and GTPase-activating ...
12
Analysis of Rab GTPase-Activating Proteins Indicates that Rab1a/b and Rab43 Are Important for Herpes Simplex Virus 1 Secondary Envelopment
... Localization of viral glycoproteins in the absence of func- tional Rab43. While the cellular role of Rab1 has been well described, the role for Rab43 is less well understood. Rab43 localizes to the TGN/Golgi complex and ...
10
The function of Ras proteins in Dictyostelium discoideum
... PSF secretion ceases as soon as the food supply is exhausted and is replaced by a second starvation factor. Conditioned Medium Factor (CMF). In contrast to PSF, CMF has been purified and the gene encoding it cloned (Jain ...
193
System Wide Characterization of MoArf GTPase Family Proteins and Adaptor Protein MoGga1 Involved in the Development and Pathogenicity of Magnaporthe oryzae
... small GTPase family proteins are involved in vesicle trafficking and organelle maintenance in eukaryotic ...family proteins in ...Arf proteins and found that they have shared and specific ...
20
Systems level expression correlation of Ras GTPase regulators
... of RAS GTPases must be balanced to achieve the normal physiological function in adult tis- ...of proteins sharing a func- tional ...to proteins sharing a common functional do- main like GEFs and ...
12
RAS GTPase AS THE DRUG TARGET FOR ANTI CANCER DESIGNING OF DRUG FROM TEMPLATE
... ABSTRACT: Ras proteins in association with GTP and GDP act as a bio- molecular switch for signaling cell growth, cell survival and signal ...mutated Ras proteins is found to vary in different ...
5
Opposite Roles of the F-Box Protein Rcy1p and the GTPase-Activating Protein Gyp2p During Recycling of Internalized Proteins in Yeast
... The F-box protein Rcy1p is part of a non-SCF (Skp1p-cullin-F-box protein) complex involved in recycling of internalized material. Like rcy1⌬, cells lacking the Rab-GTPase Ypt6p or its heterodimeric GEFs Rgp1p and ...
10
PHYLOGENETIC ANALYSIS OF RAS SUBFAMILY PROTEINS
... occupied by aliphatic side chains: alanine, valine, isoleucine, and leucine, which is 85.03, 82.96, 81.96, 82.76 and 81.62 for KRAS, NRAS, HRAS, RASSF2 and DIRAS1 respectively. It may be regarded as a positive factor for ...
11
Saccharomyces cerevisiae Putative G Protein, Gtr1p, Which Forms Complexes With Itself and a Novel Protein Designated as Gtr2p, Negatively Regulates the Ran/Gsp1p G Protein Cycle Through Gtr2p
... and GTPase-activating factors of Gsp1p, respectively, and their mutations, prp20-1 and rna1-1, can both be suppressed by Saccharomyces cerevisiae ...Ran/Gsp1p GTPase cycle through ...
15