rat aorta
Relaxant effects of Lippia microphylla Cham. (Verbenaceae) on isolated rat aorta and trachea
... Isolated rat aorta: After endothelium removal the vasorelaxation effect of LM-EtOH (3 - 243 µg/mL) was concentration-dependent either by phenyleph- rine or KCl contractions ...
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Vasodilator Effect of Olive Leaf Aqueous Extract and Involvment of Cyclooxygenase in the Rat Aorta
... We have investigated some mechanism of vasorelaxant effect of olive leaf aqueous extract in rat aorta ring. In the isolated aorta pre-contracted with phenylephrine cumulative concentration of extract ...
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The dihydropyridine calcium channel blocker benidipine prevents lysophosphatidylcholine-induced endothelial dysfunction in rat aorta
... Tracings showing relaxant response to ACh (endothelium-dependent vasodilator) in isolated rat aorta. Benidipine or vehicle was administered orally to rats. Thoracic aortas were isolated at 90 min following ...
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Regulation of insulin like growth factor I and its receptor in rat aorta after balloon denudation Evidence for local bioactivity
... Local production of growth factors may play a major role in vascular repair after injury. We examined the regulation of insulin-like growth factor-I (IGF-I) and its specific membrane receptor in balloon-denuded ...
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Effects of the Aqueous Extract Leaves of Celtis Durandii Engler (Ulmaceae) on Constriction of Rat Aorta
... Celtis durandii is a medicinal plant highly used in Cameroon for the treatment of cardiovascular disorders. The vasorelaxant effects of the aqueous extract leaves of C. durandii were examined on isolated rat ...
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Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta
... Our intensive training program did not potentiate and/ or reverse the ACh and ADPβS-induced EDR in both groups. This phenomenon could be explained by an ex- cessive ROS production as compared to the positive shear stress ...
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Effect of cymbopogon citratus and citral on vascular smooth muscle of the isolated thoracic rat aorta
... involving vasodilatation or specifically vascular smooth muscles are often performed using isolated blood vessels. Isolated blood vessel pharmacology research allows scientists to explore mechanisms of action and to ...
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Inhibitory Effect of Fentanyl on Phenylephrine Induced Contraction of the Rat Aorta
... 18. Saussy DL Jr, Goetz AS, Queen KL, King HK, Lutz MW, Rimele TJ. Structure activity relationships of a series of buspirone analogs at alpha 1 adrenoceptor: further evidence that rat aorta alpha-1 ...
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Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta
... vations, we hypothesized that the cardiovascular effect of cinnamaldehyde may be due to signaling beyond the recep- tor level. In the present study, we systematically evaluated the vasodilatory effects of cinnamaldehyde ...
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Alpha 1 adrenergic receptor induced c fos gene expression in rat aorta and cultured vascular smooth muscle cells
... that rat aorta prominently expressed mRNA for alpha 1B and alpha 1A/D ...in aorta is mediated by a chloroethyl- clonidine-sensitive receptor subtype signaling via increasing intracellular ...
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Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta
... vasculature [30]. Furthermore, it has been demonstrated that the aortic preparations from diabetics showed an impaired endothelium-dependent relaxation to acetyl- choline [14,15,18,31]. Abnormalities in vessels of ...
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Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta
... examined, using quantitative autoradiography, the expression of angiotensin II receptor subtypes AT1 and AT2, and angiotensin-converting enzyme, in the neointima formed in the rat thoracic aorta 15 d after ...
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Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery
... in rat aortas are not due to altered hormonal ...in rat aortas and pulmonary ...the aorta, this response slightly increased in the pulmonary ...the aorta than pulmonary artery ...the ...
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Effects of Androgen Treatment on the Male Rat Aorta
... The amounts of mural fibrous proteins, elastin and collagen, were significantly increased in treated animals; noncollagenous, alkali-soluble protein, thought to reflect the cellular comp[r] ...
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Chilean crude extract of Ruta graveolens generates vasodilatation in rat aorta at subtoxic cellular concentrations
... rat’s aorta incubated and measured in isolated organ bath, and evaluating the toxicity effect in CRL-1730 cell line, through enzymatic assay (MTT), confocal microscopy (propidium iodide stain) and flow cytometry ...
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Fibronectin biosynthesis in the rat aorta in vitro Changes due to experimental hypertension
... 2, A, B, and C, shows representative data on "S-methionine incorporation into total protein and immunoprecipitable fibronectin in the aortic SDS extracts of control and 2 1-d treated rat[r] ...
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Thyroid hormone dysfunctions affect the structure of rat thoracic aorta: a histological and morphometric study
... the rat aorta smooth muscle proliferation by up-regulating a gene called NOX 1 ...the aorta are responsible for the production of extracellular matrix ...
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Peroxynitrite-induced Nitration of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Promotes Their Binding in Diabetic Angiopathy
... Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) play crucial roles in diabetic angiopathy. In vivo, how- ever, the following facts remain unknown: whether COX-2 and iNOS bind, how ...
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Effect of Subchronic Administration of Captopril on a1-Adrenoceptor Agonist-Induced Contraction of Isolated Aorta in Rat
... A ngiotensin converting enzyme (ACE) is a dipeptidyl carboxipeptidase which cleaves angiotensin I (AngI) to angiotensin II (AngII), a potent vasoconstrictor agent. It is well established that AngI produced by renin has ...
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microRNA-98 mediated microvascular hyperpermeability during burn shock phase via inhibiting FIH-1
... To investigate the possible mechanism underlying burn- induced microvascular permeability, in vitro burn injury models of rat aorta endothelial monolayer cells stimu- lated with burn serum were utilized in ...
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