Rat hippocampal neurons
-induced toxicity, oxidative stress, and apoptosis in primary cultured rat hippocampal neurons by targeting miR-132
... the rat spinal cord injury (a neurological disease) model and XIST knockdown has a prominent protective effect on the recovery of spinal cord ...cultured rat hippocampal neurons by ...
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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
... cultured rat hippo- campal neurons to determine the effects of Ab aggre- gates on CREB ...of neurons with Ab fibrils resulted in 40-50% decrease in the activ- ity of CREB-responsive BDNF promoter (p ...
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Original Article Dexmedetomidine reduces hypoxia/reoxygenation injury by regulating mitochondrial fission in rat hippocampal neurons
... of rat hippocampal neurons was used to simulate cerebral I/R injury in vitro, and to explored whether DEX could affect the mitochondria fis- sion in cerebral I/R injury and its possible ...of ...
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Aging and amyloid β oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons
... our hippocampal cultures con- tain a large fraction of glial cells, about 30% in short-term cultures (3 DIV) that rise to 78–84% in long-term cultures of 10 and 20 DIV, respectively, and also, because of the ex- ...
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Original Article Protective against ischemia-reperfusion injury of rat hippocampal neurons and expression of GluR2/NR2B by dexmedetomidine by inhibition miR-199a-SIRT1 signal pathway
... in hippocampal tissues, and related with impaired neurites, regeneration and synaptic ...in hippocampal neurons after ischemia-reperfusion (I/R) injury with Dex pretreatment has not been ...utilized ...
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Measles Virus Spreads in Rat Hippocampal Neurons by Cell-to-Cell Contact and in a Polarized Fashion
... Since neurons are also polarized, we in- vestigated the sorting of F, H, and M proteins by immunoflu- orescence and confocal microscopic ...in neurons is different from that in polarized epi- thelial ...
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Decoding glutamate receptor activation by the Ca2+sensor protein hippocalcin in rat hippocampal neurons
... In neurons clamped at -60 mV glutamate application induced an inward current and spatially restricted hippocalcin-YFP translocation to many ...5 neurons; at least 2 applications to each neuron), which is ...
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Effects of Propofol on Glutamate Induced Calcium Mobilization in Presynaptic Boutons of Rat Hippocampal Neurons
... boutons attached to dendrites in particular, only about half of them responded to glutamate (Table 1). These findings are likely due to the complex effects of glutamate on the modulation of neurotransmitter release from ...
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Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons
... We intended to induce rhythmic hyperexcitation in cultured hippocampal neurons with 10 μM glutamate, to be documented by live-cell calcium imaging [19, 20]. Chromatin immunoprecipitation was performed at ...
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The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells
... dendrite localisation also seems to involve a sorting into different ve- sicles at the Golgi apparatus. Indeed, voltage gated potassium channels (Kv channels) Kv2.1 and Kv4.2 have been shown to be sorted into distinct ...
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Distribution and trafficking of JHM coronavirus structural proteins and virions in primary neurons and the OBL-21 neuronal cell line.
... JHM virus JHMV replication and trafficking of viral proteins and virions in cultured rat hippocampal neurons and a neuronal cell line, OBL-21, were examined, with an emphasis placed on t[r] ...
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Original Article Venlafaxine inhibits apoptosis of hippocampal neurons by up-regulating brain-derived neurotrophic factor in a rat depression model
... in rat hippocampal neurons, as well as its inhibitory effect on apoptosis of hippocampal ...The rat hippocampal tissue was sliced, stained and observed for BDNF distribution by ...
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Neuronal uptake of anti-Hu antibody, but not anti-Ri antibody, leads to cell death in brain slice cultures
... enter neurons during fixation and permeabilization and result in detectable levels of antibody binding to intracellular Hu or Ri antigens ...and hippocampal cultures maintained in a microscope stage ...
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Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons
... in hippocampal neurons relative to cortical ...in hippocampal cell cultures, pyramidal neurons are the predominant neuronal cell type ...the hippocampal neurons as vGLUT1 has ...
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Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
... Hippocampal slices from 16 to 22 days old Wistar rats (Taconic Biosciences (Denmark) and Charles River (Germany)) were used for electrophysiological recordings. All experimental animal procedures were conducted in ...
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Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID
... in hippocampal lysates from these ...pyramidal neurons did not exhibit a morphological ...in hippocampal CA3-CA1 physiology though, including decreased long-term potentiation (LTP) and decreased NDMA ...
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Clustered c Fos Activation in Rat Hippocampus at the Acquisition Stage of Appetitive Instrumental Learning
... suitable neurons in a new neuronal ...that hippocampal neurons are distributed in functional segments along the length of the hippocampus; moreover such segmentation ap- pears to depend on ...
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Exposure to gestational diabetes mellitus induces neuroinflammation, derangement of hippocampal neurons, and cognitive changes in rat offspring
... Young adult rats had behavioral tests starting 1 week prior their sacrifice to analyze whether GDM and/or postweaning diet affected their cognition. The behavioral tests focus on analyzing the anxiety, attention, explor- ...
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Prion protein facilitates uptake of zinc into neuronal cells
... In neurons, zinc is packaged into synaptic vesicles alongside glutamate, and both are released into the synaptic cleft upon exocytotic stimuli 2,6–8 ...postsynaptic neurons, although the molecular ...
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Morphology of Rat Hippocampal CA1 Neurons Following Modified Two and Four-Vessels Global Ischemia Models
... Materials and Methods: In this study, 20 Wistar rats were randomly divided into five groups. In group 2 and 3, both common carotid arteries were occluded for 10 minutes in either 3 or 24 hours of reperfusions, ...
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