Rat Pituitary
Pectic Acid Effects on Prolactin Secretion in GH3/B6 Rat Pituitary Cell Line
... It has been reported that pectic acid is a direct precursors of substances named called elicitors. Elicitors are fragments of pectins and β-glucan which recognize specific receptors on plant cells. Elicitors act as ...
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Effect of Alterations in Thyroid Status on the Metabolism of Thyroxine and Triiodothyronine by Rat Pituitary Gland In Vitro
... of rat pituitary gland and liver from the same animal incubated in vitro with [ 125 I]T 4 and 10 mM ...the pituitary gland, generation of 125 I-labeled 3,5,3¢-triiodothyronine (T 3 ), as well as ...
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Metabolic effect of 3,3',5' triiodothyronine in cultured growth hormone producing rat pituitary tumor cells Evidence for a unique mechanism of thyroid hormone action
... Physiologic levels of 3,3',5'-triiodothyronine (rT3) are generally believed to have minimal metabolic effects in the pituitary gland and other tissues. In the present studies, the regulatory role of rT3 and other ...
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Insulin suppresses growth hormone secretion by rat pituitary cells
... The effects of insulin on basal and hydrocortisone-induced growth hormone (GH) secretion were studied in rat pituitary tumor cells (GH3). Cells were grown in monolayer culture and exposed to exogenously ...
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Regulation of follistatin messenger ribonucleic acid levels in the rat pituitary
... in rat pituitary ...the rat pituitary, we have investigated the effects of gonadectomy (GDX) and of sex steroid replacement on pituitary follistatin gene ...individual rat ...
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Caveolin-1 sensitizes rat pituitary adenoma GH3 cells to bromocriptine induced apoptosis
... prolactin-secreting pituitary adenomas, are the most frequently found functional pituitary tumors in ...anterior pituitary gland which in turn leads to hyperprolactinemia ...other pituitary ...
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The morpho-functional parameters of rat pituitary hormone producing cells after genistein treatment
... cells of adult rats, the chronic G treatment caused an increase in the total number of ACTH cells (67). The plurihormonal cells concept is probably responsible for the increased ACTH cell number. Namely, plurihormonal ...
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Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes
... The goal of these studies was to define the rate-limiting steps in the inactivation of type 2 iodothyronine deiodinase (D2). We examined the effects of ATP depletion, a lysosomal protease inhibitor, and an inhibitor of ...
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In Vivo Manganese–MR Imaging of Calcium Influx in Spontaneous Rat Pituitary Adenoma
... In vitro Assessment of Mn 2ⴙ Uptake into Cultured Cells Mn 2⫹ uptake was evaluated in prolactin- and growth hormone– secreting rat pituitary tumor GH3 cells (ATCC, Manassas, Va). GH3 cells were cultured in ...
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Antagonism of thyroid hormone action by amiodarone in rat pituitary tumor cells
... proportional to their affinities for the receptors. We report that the benzofuran amiodarone acts as a competitive antagonist to thyroid hormone action as defined by its dose-dependent ability to (a) bind to the thyroid ...
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Apoptotic and Necrotic Effects of Pectic Acid on Rat Pituitary GH3/B6 Tumor Cells
... Background: Pectin is composed of complex polysaccharides that can inhibit cancer metastasis and proliferation with no evidence of toxicity. In the present study, the apoptotic and necrotic effects of pectic acid (PA) on ...
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Specific plasma membrane receptors for reovirus on rat pituitary cells in culture
... Specific cellular and host tropism is a characteristic property of many viruses mediated by the interaction of viral attachment proteins with components of the plasma membrane of the cell. We have studied the binding of ...
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Secondary amenorrhea in a woman with spinocerebellar degeneration treated with thyrotropin releasing hormone: a case report and in vitro analysis
... anterior pituitary gland to secrete TRH and thereby regulates thyroid hormone secretion ...to rat pituitary cells [6] or when intravenously infused to humans ...
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Mineralocorticoid and glucocorticoid effects on 31,000 and 29,000 dalton proopiomelanocortin in rat anterior pituitary and neurointermediate lobe
... in rat pituitary have been studied by two-dimensional gel ...anterior pituitary (AP); in both tissues the predominant species appeared to be of 29,000-dalton ...
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Heparin binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription
... primary rat pituitary and pi- tuitary tumor cell cultures with recombinant FGF-4 and also stably transfected pituitary cell lines with full-length human hst ...• pituitary adenoma • growth ...
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Mechanisms for pituitary tumorigenesis: the plastic pituitary
... hypothalamic–anterior pituitary unit integrates stimulatory and inhibitory central and peripheral sig- nals to synthesize and secrete hormones by five highly differentiated cell types: somatotrophs, gonadotrophs, ...
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Thyroid hormone action Demonstration of similar receptors in isolated nuclei of rat liver and cultured GH1 cells
... intact rat pituitary GH1 cells in culture, isolated GH1 cell nuclei, or rat liver ...and rat liver nuclei, and both values were similar to that determined in intact GH2 ...
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Insulin regulation of rat growth hormone gene transcription
... We have previously shown that insulin suppresses growth hormone (GH) messenger (m) RNA levels in rat pituitary cells. To further delineate the molecular mechanism of insulin action, the effect of insulin ...
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Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes
... anterior pituitary and it has been reported to act as a gonadotropin secretagog (Horvath et ...anterior pituitary (McArdle et ...the pituitary CNP system, the biological consequence of ANP signaling ...
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Differential expression of microRNAs in GH-secreting pituitary adenomas
... the PI3K regulatory subunit beta (p85b). Guo et al. [22] reported that miR-126 modulated the activity of PI3K at the level of signal initiation by limiting p85b levels in the normal colon epithelium. Loss of miR-126 ...
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