Rb, retinoblastoma
Cooperation between Rb and Arf in suppressing mouse retinoblastoma
... Human retinoblastoma is initiated by mutation of both alleles of RB, but other changes are required for malignancy (1, ...2). RB is a central regulator of proliferation that acts to inhibit E2F ...
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Going viral: a review of replication-selective oncolytic adenoviruses
... APC: adenoidal-pharyngeal-conjunctival virus; CAR: coxsackie and adenovirus receptor; CR-2: conserved region 2; CRAds: conditionally replicative Ad; CTLA-4: cytotoxic T-lymphocyte antigen 4; DC: dendritic cell; GMCSF: ...
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RECENT DEVELOPMENTS IN DENT INFORMATICS: ROLE OF BIOINFORMATICS
... Rb retinoblastoma, p53, and p16INK4A are TSG involved in HNSCC.[7, 13, 14] In this review article, comprehensive studies have done of research progress or application of bioinformatics t[r] ...
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Cell Cycle Association of the Retinoblastoma Protein Rb and the Histone Demethylase LSD1 with the Epstein-Barr Virus Latency Promoter Cp
... with Rb. Coimmuno- precipitation assays demonstrated that E2F1, Rb, and LSD1 bind to Cp in a cell cycle-dependent ...manner. Rb and LSD1 binding to Cp increased after the S phase, corresponding to a ...
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What do non-ophthalmic health professionals know about retinoblastoma: a survey in Saudi Arabia
... Less than half of non-ophthalmic healthcare professionals of Qassim region had an acceptable level of knowledge regarding retinoblastoma and its management. It was significantly better among males and physicians ...
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BIOLOGICAL ACTIVITY OF INDOMETHACIN LOADED NANOPARTICLES
... The results were confirmed in retinoblastoma cells WERI-Rb-1 (Fig. 9). The cells did not form a monolayer but grew as large clusters (Fig. 9D). All cells died after 18 hours in the sample treated with ...
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Molecular aspects of the teratogenesis of rubella virus
... 7]. Retinoblastoma tumor suppressor protein (Rb), regu- lates multiple pathways that influence cell proliferation and differentiation, by interacting with several transcrip- tion factors and suppress ...
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Induction of Transformation and p53-Dependent Apoptosis by Adenovirus Type 5 E4orf6/7 cDNA
... a retinoblastoma protein (RB)-nonbinding and therefore E2F-nonreleasing mutant of Ad5 E1A (dl922/947) to morphologically transform primary rat cells, suggesting that E2F is an important cellular protein ...
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Primary cilia and aberrant cell signaling in epithelial ovarian cancer
... progression [35,66]. Therefore, we speculated whether the low frequency of primary cilia in cancer OSE cells results from a high rate of proliferation. To address this, we analyzed the wt and cancer OSE cells by WB and ...
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A mouse model of MYCN driven retinoblastoma reveals MYCN independent tumor reemergence
... of Rb deficiency, these tumors evolved to not require ...MYCN-driven retinoblastoma will also likely result in the reemergence of tumors independently of ...the Rb/p107 model ...the ...
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Role of the retinoblastoma gene in the initiation and progression of human cancer
... In addition, recent evidence suggests that the loss of Rb gene function is not only causally related to the development of retinoblastoma and tumors that occur as second cancers in patie[r] ...
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<p>Dinutuximab Synergistically Enhances the Cytotoxicity of Natural Killer Cells to Retinoblastoma Through the Perforin-Granzyme B Pathway</p>
... primary retinoblastoma cultures exerted quite different levels of sensitivity to the combination of NK-92MI hCD16-GFP cells and ...SNPH- Rb-C24 cells, but a much smaller effect on RBJY ...to ...
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Ubiquitin-Independent Proteasomal Degradation of Tumor Suppressors by Human Cytomegalovirus pp71 Requires the 19S Regulatory Particle
... the retinoblastoma (Rb) family members Rb, p107, and p130 ...pression. Rb family inactivation, which also occurs through phos- phorylation by the virally encoded kinase UL97 (12), likely in- ...
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<p>Long Noncoding RNA SNHG16 Sponges miR-182-5p And miR-128-3p To Promote Retinoblastoma Cell Migration And Invasion By Targeting LASP1</p>
... of retinoblastoma cells. LASP1 was up-regulated in both retinoblastoma cells and tissues (Figure 4A and B) and knockdown of LASP1 inhibited migration and invasion of retinoblastoma cells (Figure 4C ...
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Trilateral retinoblastoma: two variations
... recurrent ocular disease (6, 7, 11). Holladay et al (6) in 1991 reported three cases and re- viewed 32 cases in the literature of “true” tri- lateral retinoblastoma, with respect to their clinical presentation, ...
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Effect of rubidium incorporation on the optical properties and intermixing in Mo/Si multilayer mirrors for EUV lithography applications
... the most substantial contribution to the throughput of EUV light after multiple reflections. As Table 1 illustrates, Mo/Rb MLMs show the highest peak re fl ectivity (Peak1 = 81.2%). Accordingly, their normal- ized ...
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Spinal cord RB
... • Posterior gray horns contain somatic and visceral sensory nuclei • Anterior gray horns contain somatic motor nuclei. • Lateral gray horns are in thoracic and lumbar segments ; c[r] ...
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Efferocytosis in Retinoblastoma
... of retinoblastoma were seen where nuclear fragmentation and apoptotic vesicle arrangement were realized and macrophages in the process showed their phagocytic ac- tions on the apoptotic ...
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The Content of Silver, Cobalt, Chromium, Iron, Mercury, Rubidium, Antimony, Selenium, and Zinc in Osteogenic Sarcoma
... Moreover, we found significantly lower values of Rb/Co, Rb/Fe, Rb/Se, and Rb/Zn mass fraction ratios as well as significant higher mean values of Co × Zn, Fe × Zn, Sb × Zn, Se × Zn, Co ×[r] ...
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Temperature dependence of entropy of mixing of liquid alkali alloys
... A semi-empirical approach has been considered to study the temperature dependence of entropy of mixing, (Δs M ), for various alkai-alkali alloys using hard-sphere model. The most important physical parameters occurring ...
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