Reaction scheme for solid-phase DNA synthesis
SOLID PHASE SYNTHESIS
... the solid matrix not only does not have detrimental effects on the synthesis but actually has beneficial effects in certain ...classical synthesis in homogeneous solution is insolubility of some ...
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SOLID PHASE PEPTIDE SYNTHESIS
... Sudden shrinkages should alarm the op- erator. This phenomenon is caused by the aggregation of the peptide chain which will impede the continuation of the synthesis. Complete coupling reaction and ...
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Solid phase protein chemical synthesis
... the solid phase sequential chemoselective ligation of un- protected peptides ...chemical synthesis were assembled in solution using the NCL reaction (see ...The synthesis of large ...
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Solid phase synthesis of recyclable diphosphine ligands
... the Synthesis of Cyclic Sulfates Step 1 To a solution of diol ...the reaction was quenched by addition of 20 ml of ice ...aqueous phase was extracted three times with 10 ml of Et 2 ...next ...
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Solid-Phase Synthesis of Peptide−Viologen Conjugates
... Fmoc-based solid-phase peptide ...each reaction has allowed us to optimize reaction times as a function of peptide sequence and to assure completion of the water-sensitive activation and ...
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Microwave Assisted Solid Phase Synthesis of Trisubstituted
... Keywords: Solid phase synthesis; chlomethyl polystyrene; substituted pyrimidines _____________________________________________________________________________ INTRODUCTION Many biologically active ...
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Optimization of solid phase synthesis of quinazolin 4 ones
... for synthesis of ...the reaction mixture was concentrated in high vacuum and the residue was subjected to HPLC ...the reaction was run with 50 mmol of the reagents and the crude product was extracted ...
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Synthesis of novel interlocked architectures in solution and solid phase
... “click” reaction will be explored as a means of functionalising polysterene resins with novel ...the solid- tethered [2]rotaxanes by gel-phase 1 H HR MAS NMR will enable a direct comparison with the ...
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Cyanopivaloyl Ester in the Automated Solid-Phase Synthesis of Oligorhamnans
... the synthesis of complex oligosaccharides. Automated solid-phase synthesis is an attractive technique for the rapid assembly of oligosaccharides, built up of repetitive ...multiple ...
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Solid-phase synthesis of peptide - metal-complex conjugates
... Abstract: Solid-phase synthesis is a convenient and established method for the preparation of peptide based ...However, solid-phase synthesis of inorganic complexes is a rather ...
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Solid-phase synthesis of C-terminally modified peptides
... cycloaddition reaction, also known as click ...amination reaction and attached to the resin in almost quantitative yields (entry 22 to ...the solid phase at the ...
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Studies in Solid Phase Peptide Synthesis: A Personal Perspective
... neutralization and cyclization of a polymeric peptide nitrophenyl ester. The release of a peptide oxazolone from the polymer support prior to cyclization cannot be ruled out. The formation of a peptide oxazolone would of ...
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Development of New Tags for Solid-phase Peptide Synthesis
... iterative refolding, a technique based on repeated cycles of renaturation and denaturation. During the matrix-assisted refolding, the target protein is bound via the His-tag to the Ni-NTA support. After renaturation, ...
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Rapid Microwave-Assisted Solid Phase Peptide Synthesis
... on solid phase peptide synthesis (SPPS), peptide preparation has almost exclu- sively been performed on ...in solid supported ...with solid phase synthesis, 3 possibly due ...
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DESIGN AND SYNTHESIS OF HANDLES FOR SOLID-PHASE PEPTIDE SYNTHESIS AND CONVERGENT PEPTIDE SYNTHESIS. A Dissertation
... The solid support must have the following characteristics3 for an efficient solid-phase synthesis: 1) physical stability and of the right dimensions to allow for liquid handling and ...
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REACTION AND KINETIC STUDIES ON CATALYTIC VAPOR PHASE PYRIDINE SYNTHESIS
... crucial issue either in movin g or fluid bed options since solid motion introduces the attrition and blocka g e complications. To facilitate insitu re g eneration and recycle of the catalyst particles, a fluid bed ...
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Regeneration of Aged DMF for Use in Solid-Phase Peptide Synthesis
... suspended in DCM (1 mL) with agitation for 15 min. Fmoc-Gly-OH (3 equiv.) and HCTU (3 equiv.) dissolved in the solvent † (0.4 mL) was added to the reactor followed by agitation for 5 min. In the case of greener ...
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Synthesis of Transition Metal Dichalcogenides from Solid Phase Precursors
... (semi-)metallic phase, due to their much higher ...evolution reaction (OER) and the ORR, and demonstrated im- proved catalytic behaviour post surface ...1T’ phase to be much more active than the ...
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Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis
... continuous solid-phase synthesis approach was utilized to obtain prodrug 6 (Scheme 4) (Supplementary Materials Figure ...manual synthesis of the pentapeptide using a down-loading ...
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Initial studies on the development of a solid phase synthesis of vancomycin and analogues
... Solution phase synthesis; 3.3.1. The synthesis of Fmoc-protected dipeptide D1 using EDC/HOBt in ...the solid phase. Accordingly, it was important to try a solution phase method ...
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