Receptor, B2
Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice
... scavenger receptor B2 (hSCARB2), which are required for viral uncoating, and attachment receptors, such are heparan sulfate (HS), which bind vi- rus but do not support ...
16
Gender-related associations of genetic polymorphisms of α-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor with treadmill exercise test responses
... cardiovascular performance during exercise testing. Therefore, we evaluated associations between functional genetic polymorphisms of α -adrenergic receptors, endothelial nitric oxide synthase, bradykinin receptor ...
8
The relationship of Bradykinin B2 receptor gene variation with obesity, hypertension and lipid variables in obese patients
... insulin receptor and in- sulin receptor substrate-1, and B 2 R enhances dephosphorylation of the insulin receptor ...bradykinin receptor has two sub- types, namely; bradykinin B1 (B 1 R) and ...
11
Exploring the Horizons of Ephrin B2 Receptor for Combating Paramoxyviridae Infection
... Ephrine B2 which is a transmembrane receptor which is approximately of 40kda of size, belongs to the class of Eph ...Ephrin- B2 along with its cognate receptors B3 and B4 are expressed in ...
5
The design and synthesis of non-peptide bradykinin B2 receptor antagonists
... Two recent literature reports on the use of the 1,4-benzodiazepin-2-one (BZD) scaffold to mimic a peptide reverse turn are outlined. These reports have been used to formulate a hypothesis that the C-terminal p-turn in ...
288
In vivo bradykinin B2 receptor activation reduces renal fibrosis
... It is known that bradykinin is involved in the control of a wide range of physiological functions, including car- diovascular homeostasis (regulation of systemic blood pressure and organ blood flow), water and ...
10
IMPACT OF GLN/GLU27 POLYMORPHISM OF B2 ADRENERGIC RECEPTOR ON BRONCHIAL ASTHMA SUSCEPTIBILITY AND DRUG RESPONSE IN CHILDREN
... 79, can cause differential agonist-stimulated down-regulation in cell systems of the B2 adrenergic receptor, affecting human airway smooth muscle cells and drug response [8] . Several previous studies have ...
10
Administration of angiotensin II and a bradykinin B2 receptor blocker in midpregnancy impairs gestational outcome in guinea pigs
... constitutive B2 receptor (B2R) and the B1 receptor, the latter of which is scarcely expressed in normal tissues and is mainly induced by tissue injury, endo- toxins, or cytokines ...tutive ...
8
Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy
... B1and B2. Among these two receptors, B2 receptor in constitutively expressed on the surface of many cell types under physiological conditions ...kinin B2 receptor antagonist, blocks the ...
8
Control of B2 bradykinin receptor gene expression
... saturable B2 bradykinin receptor binding of pH]- BK to m em brane p rep aratio n s has been d em o n strated for epithelial, cardiac muscle, intestinal, tracheal, respiratory tract and uterine smooth muscle ...
190
Deletion of Osteopontin Enhances b2-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes
... signaling, including 2 AR-induced cAMP production, in H9c2 cardiomyocytes. Epac1 upregulation by OPN CRISPR-mediated deletion in H9c2 cardiomyocytes 158[r] ...
23
Novel signaling of dynorphin at κ opioid receptor/bradykinin B2 receptor heterodimers
... single-transfected cells and HEK293 cells (Fig. 7A), which is consistent with the evaluation of cAMP accumulation, confirming that the major downstream signaling of KOR/B2R heteromers is the cAMP pathway via Gαs protein. ...
35
Infrared emitting, peptidase resistant fluorescent ligands of the bradykinin B2 receptor: application to cytofluorometry and imaging
... Background: We have previously reported the design, pharmacological properties and imaging application of brad‑ ykinin (BK) B 2 receptor (B 2 R) ligands conjugated with fluorophores such as fluorescein derivatives ...
10
Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis
... ephrin B2 (Efnb2), a gene encoding a transmembrane signaling molecule specifically expressed in arterial ECs prior to the onset of circulation, unveiled a genetic program of arteriovenous differentiation (Wang et ...
10
Mechanisms of hyperresponsiveness in the human nasal airway: Role of kinins and nitric oxide
... The mechanism of MBP-induced AHR is unknown, though it may be dependent on causing epithelial damage (Gleich et al., 1988), since MBP only induces AHR in guinea pig tracheal preparations with an intact epithelium ...
271
Senescence associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
... bradykinin B2 receptor increases the severity of a variety of senescence-associated changes that occur in untreated diabetic ...the B2 receptor on TBARSs and GSH were both highly significant ...
9
An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell specific over expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary selective resistance to thyroid hormone
... TR b2 isoforms from specific promoters (Figure ...TR b2 is restricted with main sites of expression in the anterior pituitary, hypothalamus, cochlea and retina ...TR b2 in the pituitary and retina in ...
7
Hereditary angioedema: what the gastroenterologist needs to know
... bradykinin B2-receptor antagonist, or a kallikrein inhibitor as first-line therapy and solvent/detergent-treated or fresh frozen plasma as second-line therapy for acute ...
11
Antibodies to Henipavirus or Henipa Like Viruses in Domestic Pigs in Ghana, West Africa
... quantified by the fluorescence emitted by phycoerythrin. This is read as the median fluorescence intensity (M.F.I.). Gamma- irradiated positive pig and cat sera controls from naturally or experimentally infected animals, ...
5
Label-free quantitative mass spectrometry analysis of differential protein expression in the developing cochlear sensory epithelium
... lipoprotein receptor-related protein 2, which are involved in the de- velopment of sensory organs [49] and nervous system [50, 51] and thus may contribute to the development of the cochlear sensory ...
15