Receptor Binding Specificity
The Receptor Binding Specificity of the Live Attenuated Influenza H2 and H6 Vaccine Viruses Contributes to Vaccine Immunogenicity and Protection in Ferrets
... and receptor binding specificity of H2 vaccine vi- ...affect receptor binding preference and host range (13, 28, ...on receptor binding specificity and replication ...
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Alterations in Hemagglutinin Receptor-Binding Specificity Accompany the Emergence of Highly Pathogenic Avian Influenza Viruses
... HA receptor-binding and NA receptor-destroying activities of a panel of HPAIVs and LPAIVs using a set of synthetic receptor analogs, ␣ 2-3-sialylated glycopolymers, and determined that ...
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Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution
... the receptor binding ...the receptor binding site are different in H1 ...dual receptor binding speci- ficity of the D225G mutant and summarize how the different amino acid ...
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Effects of Receptor Binding Specificity of Avian Influenza Virus on the Human Innate Immune Response
... 2,6 receptor binding receptor ...of receptor binding specificity to the initiation of innate immune responses in human ...the receptor binding site of the HA and ...
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Receptor binding specificity and origin of 2009 H1N1 pandemic influenza virus
... New influenza viruses arise through genetic reassort- ment. The 2009 H1N1 virus is a novel virus with its eight gene segments derived from North American and Eurasian swine lineages [1]. Intensive research on this virus ...
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Interactions between the two surface proteins of rotavirus may alter the receptor-binding specificity of the virus.
... The infection of target cells by most animal rotavirus strains requires the presence of sialic acids (SAs) on the cell surface. We recently isolated variants from simian rotavirus RRV whose infectivity is no longer ...
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Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6
... its receptor binding activity was ...acid receptor; no binding to the mammalian ␣2-6-linked sialic acid receptor was ...H13 receptor binding specificity was ...
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Quantifying the effects of mutations on receptor binding specificity of influenza viruses
... by binding of HA1 to its host cell receptors and followed by the fusion between viral and host endosomal membranes mediated by ...the receptor binding specificity from each mutation in HA1 in ...
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Relationship between mitogenic activity of influenza viruses and the receptor-binding specificity of their hemagglutinin molecules.
... The ability of anti-I-E MAb to block H2 influenza virus-induced mitogenesis and the ability of H2 virus to inhibit the binding of anti-I-E MAb to spleen cells indicate that the B-cell re[r] ...
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Identification of highly conserved domains in hemagglutinin associated with the receptor binding specificity of influenza viruses: 2009 H1N1, avian H5N1, and swine H1N2
... Using sequence analysis and homology modeling [4], the HA protein of 2009 H1N1 was found to have the signature amino acid Asp190 and Asp225 known to confer binding affinity to α2-6 sialylated glycan recep- tors. ...
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Influenza H1N1 A/Solomon Island/3/06 Virus Receptor Binding Specificity Correlates with Virus Pathogenicity, Antigenicity, and Immunogenicity in Ferrets
... bind to the epithelial surface of the trachea less well but bind avidly to the submucosal connective tissue. These results are in agreement with those reported previously for the distribution of receptors in the ...
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Structural Basis for the Receptor Binding Specificity of Norwalk Virus
... sugar- binding pocket of the P dimer ...sugar binding by the P particle is the stoichiometric result of the presence of multiple sugar binding ...
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Subtle differences in receptor binding specificity and gene sequences of the 2009 pandemic H1N1 influenza virus
... the receptor binding patterns of the two ...man binding affinity, their secondary binding pref- erences were ...swine binding as its secondary binding pattern, whereas cluster ...
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Receptor binding specificity of recent human H3N2 influenza viruses
... minimum binding motif: Neu5Acα2-6Galβ1-4GlcNAc, as in polylactosamine struc- tures found on N- and O- linked carbohydrates or Neu5Acα2-6GalNAcβ1-4GlcNAc- (Fig ...higher binding to longer and fuco- sylated ...
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A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice
... (HA) receptor binding site, which is critical for binding human type sialic acid ...virus receptor binding specificity but enhances binding affinity to human cells and ...
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Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition
... amino acid substitutions at residue 145 were tested for receptor binding specificity with varying 713. concentrations of SAα2-3Gal (α2-3-linked SA) or SAα2-6Gal (α2-6-linked SA).[r] ...
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Highly conserved domains in hemagglutinin of influenza viruses characterizing dual receptor binding
... primary receptor binding preference in [12] (Table ...primary receptor binding preference in different subtypes were discovered (Table ...of receptor binding specificity ...
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Envelope Determinants for Dual-Receptor Specificity in Feline Leukemia Virus Subgroup A and T Variants
... a receptor. In some cases, such as FeLV-T, a nonclassical receptor that includes both a transport protein (Pit1) and a soluble cofactor (FeLIX) is required for ...confer specificity to classical ...
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PDZ domains and their binding partners: structure, specificity, and modification
... AMPA receptor GluR2 subunit is phosphorylated by PKC in vitro and in vivo ...vivo binding studies have shown that phos- phorylation significantly decreases binding of GluR2 to the PDZ domain of ...
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Injury affects coelomic fluid proteome of the common starfish, Asterias rubens
... The largest fraction of the CF proteome is represented by pattern recognition receptors. As echinoderms, starfish lack an acquired immunity, relying on the presence of pattern recognition receptors for discriminating and ...
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