receptor trafficking
Inhibition of AMPA receptor trafficking at hippocampal synapses by β-amyloid oligomers: the mitochondrial contribution
... endo/exocytotic trafficking of membrane ...synaptic receptor trafficking: the former requires a high Ca 2+ elevation for activating CaMKII and downstream effectors for AMPA insertion whereas the ...
13
VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation
... AMPA receptor trafficking, which may underlie its function in promoting spine mat- uration and glutamatergic neurotransmission, revealing a molecular mechanisms by which VPS35/retromer in hippocampal ...
12
A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function
... lipophilic characteristics of steroidal ligands, they may interact differentially with membrane components. However our mass spec studies in fact showed an accelerated ligand accumulation with the NSGs compared to Dex. ...
11
Protease-activated receptor 4 variant p.Tyr157Cys reduces platelet functional responses and alters receptor trafficking
... The common coding PAR4 A120T variant (rs773902), has previously been associated with gain of PAR4 receptor function. 19 Since the index case Y157C.1 was heterozygous for A120T, this may have modified the phenotype ...
20
Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia
... Several studies have reported the involvement of SMAP1 in onco- genesis in humans. For example, the MLL gene is a frequent target for recurrent chromosomal translocations in acute myeloid leu- kemia (AML), and more than ...
16
Dpp gradient formation by dynamin dependent endocytosis: receptor trafficking and the diffusion model
... We then addressed whether the levels of surface Tkv are altered in shibire mutant clones when endocytosis is blocked. Fig. 5E shows that in the shibire mutant cells after 5 hours at the restrictive temperature (the ...
14
Insect odorant receptor trafficking requires calmodulin
... projection neuron output into higher brain centers, ra- ther than via changes in the OSNs themselves [30, 31]. Interestingly, although flies exposed to a high concen- tration (10 -1 v/v) of benzaldehyde for 4 days show ...
14
Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.
... control receptor availability at the plasma membrane and dictate trafficking before recycling or ...of receptor ubiquitination significantly impairs endocytosis resulting in increased cell surface ...
24
Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs
... Here we firstly confirm our previous observations [24] that NMDA results in a rapid and reversible decrease in fluorescence in dendritic shafts and a delayed decrease in fluorescence in puncta (putative spines). Secondly ...
10
A leptin fragment mirrors the cognitive enhancing and neuroprotective actions of leptin
... driven trafficking of GluA1 involves inhibition of PTEN (Moult et al, ...GluA1 trafficking involves inhibition of PTEN, as application of the PTEN inhibitor bpV blocked the increase in GluA1 surface ...
42
Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants
... We identified sec8 mutants in an unbiased forward genetic screen for mutations causing defects in development of glutamatergic Drosophila neuromuscular junctions (NMJs) [5,6]. Sec8 is a core member of the sec 6/8 ...
20
Trafficking routes to the plant vacuole: connecting alternative and classical pathways
... KŸnzl F, FrŸholz S, FŠ§ler F, Li B, Pimpl P. 2016. Receptor-mediated sorting of soluble vacuolar proteins ends at the trans-Golgi network/early endosome. Nature plants 2, 16017. Lee KH, Piao HL, Kim H-Y, Choi SM, ...
34
Original Article Characterization of karyopherins in androgen receptor intracellular trafficking in the yeast model
... Abstract: Background: Mechanisms regulating androgen receptor (AR) subcellular localization represent an es- sential component of AR signaling. Karyopherins are a family of nucleocytoplasmic trafficking ...
12
Combating Human Trafficking with Multimodal Deep Models
... Detecting whether or not an advertisement is suspi- cious requires years of practice and experience in working closely with law enforcement. As a result, annotation is a highly complicated and expensive process, which ...
10
LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance
... Several other hypotheses suggest a link between GC mutations and α-syn accumulation (10). For example, mutant GC localizes to LBs (39) and has been shown to interact directly with α-syn (40). Another group identified ...
6
Organized Crime Phenomenon Threatening Public Safety and Rule of Law in Kosovo
... They are involved in many areas of criminal activity ranging from drug trafficking, human trafficking, goods trafficking (weapons, stolen cars, cigarettes, etc.), as we[r] ...
17
Human Trafficking in South Asia: Issues of Corruption and Human Security
... of the region has been prevalent. While on the move, people may become more vulnerable to exploitation in several forms. Trafficking for commercial sexual exploitation is considered as the most virulent form in ...
10
Molecular mechanisms of GABAA receptor anchoring and trafficking
... ^ receptor subtypes provides the p o te n tia l fo r c o n s id e ra b le stru c tu ra l d iv e rsity ...study receptor assem bly and clustering in live ...study receptor processes (C arter and ...
171
Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking
... CGRP-induced receptor internalization may be due to the overexpression system in the current study wherein the rate-limiting ma- chinery of internalization is out-numbered by the over- whelming amount of the ...
12
The Endosomal Protein-Sorting Receptor Sortilin Has a Role in Trafficking α-1 Antitrypsin
... ABSTRACT Up to 1 in 3000 individuals in the United States have a-1 antitrypsin deficiency, and the most common cause of this disease is homozygosity for the antitrypsin-Z variant (ATZ). ATZ is inefficiently secreted, ...
24