Receptors, Nicotinic
Long lasting depolarization of leech neurons mediated by receptors with a nicotinic binding site
... neuronal nicotinic receptors are a highly diverse family of ligand-gated ion channels present in neurons of the central nervous system of vertebrates and invertebrates (Gerschenfeld, 1973; McGehee and Role, ...
12
Nicotinic acetylcholine receptors: specific antibodies and functions in humoral immunity
... α7-containing nicotinic receptors in knockout mice or their desensitization in mice chronically treated with nicotine decreased the number of myeloid and erythroid progenitors and junior ...containing ...
10
Nematode nicotinic acetylcholine receptors: a single channel study in Ascaris suum and Caenorhabditis elegans
... Cholinergic neurotransmission mediated by nicotinic acetylcholine receptors (nAChRs) plays important roles in both vertebrates and invertebrates. In vertebrates, dysfunctions of certain subtypes of neuronal ...
145
Effects of TI-299423 on Neuronal Nicotinic Acetylcholine Receptors
... α6-containing receptors, α4β2*-nAChRs express readily in oocytes and mammalian cell ...other nicotinic compounds on these receptors much easier to ...
95
Neuronal nicotinic receptors: the role of β3 and α5 subunits
... that nicotinic fast synaptic transmission takes place in the ...agonist-evoked nicotinic currents they ...decaying nicotinic inward current, reproduced by choline and sensitive to low concentrations ...
280
Possible role of the α7 nicotinic receptors in mediating nicotine’s effect on developing lung – implications in unexplained human perinatal death
... the nicotinic receptors that are widely expressed in the airway cells of the developing lung ...other nicotinic receptor subtypes are more ...
10
Downregulation of α7 nicotinic acetylcholine receptors in peripheral blood monocytes is associated with enhanced inflammation in preeclampsia
... The cholinergic anti-inflammatory pathway regulates systemic inflammatory responses and plays an important role in a variety of inflammation-related disorders, such as hypertension and kidney diseases [10–12]. In the ...
9
Lophotoxin insensitive nematode nicotinic acetylcholine receptors
... Nematode nicotinic acetylcholine receptors (nAChRs) are molecular targets of several anthelmintic drugs. Studies to date on Caenorhabditis elegans and Ascaris suum have demonstrated atypical pharmacology ...
8
A novel angiogenic pathway mediated by non neuronal nicotinic acetylcholine receptors
... We have recently reported that nicotine has angiogenic effects, which appear to be mediated through non-neuronal nicotinic acetylcholine receptors (nAChRs). Here, we describe the endogenous cholin- ergic ...
11
Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
... Abstract: We identified a novel class of direct ion-channel blockers of ligand-gated ion channels called the gold nanoparticle–choline complex. Negatively charged gold nanoparticles (1.4 nm) block ion pores by binding to ...
7
Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
... are nicotinic in nature and are mediated by α 7 n nAChRs since they are potentiated by PNU 120596 (a known positive allosteric modulator of α 7 n nAChRs), inhibited by methyl- lycaconitine but not DH β E, and not ...
16
Structure-function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids
... In the Cys loop superfamily of ligand-gated ion channels, a global conformational change, initiated by agonist binding, results in channel opening and the passage of ions across the cell membrane. The detailed mechanism ...
157
Binding Studies of Neuronal Nicotinic Acetylcholine Receptors Expressing Unnatural Amino Acids
... the nicotinic pharmacophore by failing to make a functionally significant additional hydrogen bond to the backbone NH of a conserved leucine residue (L119 in rat ...other nicotinic agonists studied ...
138
Lynx1 Modulation of Nicotinic Acetylcholine Receptors
... clamp to confirm that they were DA neurons (Drenan et al., 2008). DA cells were puffed with 1 and 10 µM nicotine, and these puffs were separated by at least 4 minutes to allow recovery from desensitization. For some ...
91
Nicotinic acetylcholine receptors modulate osteoclastogenesis
... Our observation that nAChR antagonists also inhibit osteoclastogenesis, coupled with our results showing re- duced osteoclastogenesis in α7–/– mice, can be inter- preted in the context of desensitization, a key property ...
12
Nicotine effects on mitochondria membrane potential: participation of nicotinic acetylcholine receptors
... The effect of nicotine on the mouse liver mitochondria was studied by fluorescent flow cy- tometry. Mice consumed nicotine during 65 days; alternatively, nicotine was added to isolated mito- chondria. Mitochondria of ...
9
Fluorescence Microscopy of Nicotinic Acetylcholine Receptors
... Mutation of a conserved leucine (L) at the 9’ position within a nAChR subunit confers “hypersensitivity” to agonist in receptors containing L9’ mutant subunits [27-29]. Thus, 9’ mutations can act as a reporter for ...
83
The assembly and folding of neuronal nicotinic acetylcholine receptors
... There have been reports that show that the subunit combinations a4/p2 and a3/p4 are located predom inantly in the CNS and the autonomic ganglia of the peripheral nervous system (PNS), respectively (Whiting et a l, 1991). ...
226
Chemical-Scale Studies of the Nicotinic and Muscarinic Acetylcholine Receptors
... In this study, we have evaluated the structural role of the highly conserved residue, D89. According to the AChBP crystal structures, D89 provides the contact point between loop A, which contains D89 and agonist binding ...
153
Chemical-scale studies of the nicotinic and muscarinic acetylcholine receptors
... Figure 1.7. Classic Zhong plot for αW149 residue of nAChR 11 Figure 2.1. Alignment of loops A and B for several Cys-loop receptors 17 Figure 2.2. Region investigated in Chapter 2 studies 18 Figure 2.3. Schematics ...
17