recombinant human interleukin-1
Recombinant human interleukin 1 induces meningitis and blood brain barrier injury in the rat Characterization and comparison with tumor necrosis factor
... mediators for induction of meningitis and BBB injury. Intracisternal challenge of rIL-1 beta into rats induced neutrophil emigration into cerebrospinal fluid (CSF) and significantly increased BBB permeability to ...
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Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1 Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163 171
... natural human interleukin (IL-1)1 beta and human recombinant (hrIL)-1 alpha and beta are potent stimulators of HA production by fibroblasts in ...
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Development of the method for microbiological purity testing of recombinant human interleukin-7-based product
... tion 1 : 50, which assures partial neutralization of antimicrobial effects, and receipt of reliable results of viable cells ...to 1 : 100 is not correct, as in case of using such dilution during control of ...
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Original Article Effect of human recombinant interleukin-10 on cytokines in adjuvant arthritis rat
... for 1 ml from inner can- thus using capillary glass tube at before model- ing, modeling, and 2 and 4 weeks after treat- ment to test serum IL-1, IL-4, and TNF-α ...
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Validation of biological activity testing procedure of recombinant human interleukin-7
... tion CV intra were carried out simultaneously. As biological activity test method is quantitative, the measurements were performed by testing 9 dilu tions, concentrations of which were uniformly dis tributed within the ...
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Fibroblast chemotaxis induction by human recombinant interleukin 4 Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70 88 and 89 122
... Fibroblast Chemotaxis Induction by Human Recombinant Interleukin-4 Identification by Synthetic Peptide Analysis of Two Chemotactic Domains Residing in Amino Acid Sequences 70-88 and 89-1[r] ...
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Granulocyte-Macrophage Colony-Stimulating Factor Amplification of Interleukin-1β and Tumor Necrosis Factor Alpha Production in THP-1 Human Monocytic Cells Stimulated with Lipopolysaccharide of Oral Microorganisms
... years, recombinant human GM-CSF has been used in the treatment of chemo- therapy-induced bone marrow suppression in patients under- going transplantation for the treatment of cancer (8, ...a human ...
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Evaluating the Effect of Oprelvekin on Cardiac Repolarization in Subjects with Chemotherapy-Induced Thrombocytopenia: An Observational Chart Review of a Phase 2 Clinical Trial in Laredo, Texas Soriano RA *1 and Gonzalez M 2
... the interleukin-11 pathway as outlined in Figures 1 and 2 ...of recombinant human interleukin 11 (rhIL-11) in severe chemotherapy-induced thrombocytopenia who those receiving a variety ...
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Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony stimulating factor 1, and recombinant murine granulocyte macrophage colony stimulating factor on myelopoiesis in mice
... (CSF) recombinant interleukin 3 (IL-3), natural CSF-1, and recombinant granulocyte-macrophage (GM) CSF were assessed in vivo for their effects on BDF1 mouse bone marrow and spleen ...
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Effect of recombinant human interleukin-7 on Pseudomonas aeruginosa wound infection
... I nterleukin-7 (IL-7) is a central cytokine of the immune system, which plays an important role in the modulation of T- and B-cell development and T-cell homeostasis [1, 2]. The potential and wide range of its ...
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Interleukin 1 stimulates fibroblasts to produce granulocyte macrophage colony stimulating activity and prostaglandin E2
... monocyte-derived IL-1 and human recombinant IL-1 (10(-10) M) can be substituted for monocyte-conditioned medium in stimulating fibroblast GM-CSA and PGE2 production. Both forms of IL-1 ...
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Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease
... of interleukin-5 is restricted to eosinophils, it should be an ideal target to block this response in the lungs of allergic animal models of asthma, and has been studied in several ...to interleukin-5 ...
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Biological properties of recombinant human monocyte derived interleukin 1 receptor antagonist
... coli. Recombinant IL-1ra has 17,000 mol wt and binds to IL-1 receptors on T lymphocytes, synovial cells, and chondrocytes with an affinity nearly equal to that of ...purified recombinant human ...
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Role of interleukin 1 in the pathogenesis of experimental shigellosis
... The effect of human recombinant interleukin-1 receptor antagonist on intestinal inflammation, tissue destruction, and bacterial invasion during experimental shigellosis caused by Shigell[r] ...
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Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells
... of human monocyte-derived IL-1 (T-lymphocyte activation and human synovial cell prostaglandin E2 and collagenase production) ...of human IL-1 was expressed, purified, and ...homogeneous ...
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Cloning and Expression of Recombinant Human Interleukin-7 in Chinese Hamster Ovary (CHO) Cells
... Enzyme-linked immunosorbent assay (ELISA) Recombinant human IL-7 secreted into the medium was measured by indirect ELISA. Wells of ELISA plates were coated with 10 µl of supernatant diluted in 40 µl of ...
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Multiple biological activities of human recombinant interleukin 1
... for human monocyte interleukin 1 (IL-1), pI 7 form, was expressed in Escherichia ...the recombinant protein. Homogeneous human recombinant IL-1 (hrIL-1) was ...
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Epidermal cytokines: Homeostasis and the regulation of langerhans cell migration and cutaneous immunity
... skin, human kératinocytes constitutively express IL-12 p35 mRNA, but the p40 mRNA that is needed for the production of the biologically active heterodimer is expressed only after exposure to contact allergen or ...
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Expression and Immunogenicity of Recombinant Immunoreactive Surface Protein 2 of Anaplasma phagocytophilum
... Bacterial strains and sera. A. phagocytophilum strain Webster (GenBank sequence accession number AY164491.1, which was kindly provided by J. S. Dumler, Medical College of Johns Hopkins University), was culti- vated in ...
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Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation
... IL-1. Human epidermis is normally exposed to significant amounts of solar ultraviolet ...cultured human keratinocytes. Cultured human keratinocytes contain detectable amounts of IL-1 ...
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