recombinant human protein C
Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation
... (TM)/activated protein C (APC) system plays an important role in maintaining the homeostasis of thrombosis and hemostasis and maintaining vascular integrity in ...activates protein C to ...
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Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin induced lung injury in anaesthetised sheep
... Activated protein C (APC) counteracts coagulation, promotes fibrinolysis [8] and inhibits leucocyte infiltration and, subse- quently, the release of pro-inflammatory cytokines ...administered ...
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Recombinant human activated protein C for the treatment of severe sepsis and septic shock: a study protocol for incorporating observational evidence using a Bayesian approach
... after the large clinical trial PROWESS-SHOCK failed to identify any bene fi cial effect in patients with sepsis. However, in the fi rst place, aPC was approved for use in patients with sepsis because the PROWESS study ...
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Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study
... In the present clinical study, we studied the dynamics of the anticoagulant, pro-fibrinolytic and anti-inflammatory action of rhAPC when used in severe sepsis, by comparing rhAPC treated patients with case controls. We ...
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Recombinant human activated protein C attenuates endotoxin induced lung injury in awake sheep
... Protein C is an inactive precursor of the serine protease acti- vated protein C (APC), which is catalyzed by the action of thrombin/thrombomodulin complex when protein C is bound ...
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Original Article Prokaryotic expression of partial E gene of DENV strain and its effect on HUVEC permeability
... E protein EDI domain, an important domain involved in by protein E medi- ating membrane fusion process [15, ...fusion protein of E gene 1-476 sequence of DENV-2 M strain and NGC strain, named M476 ...
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Cell Surface Delivery of the Measles Virus Nucleoprotein: a Viral Strategy To Induce Immunosuppression
... with human Fc␥RIIb1 were infected with a recombinant vaccinia virus expressing MV N protein (MOI, ...Nonpermeabilized human PBLs, (G to I) P815-N cells, or (J to M) P815-M cells were analyzed ...
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Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis
... prospective recombinant human activated protein C worldwide evaluation in severe sepsis; IRP: improved response polymorphism; DROTAA: drotrecogin alfa (activated); APACHE II: acute physiology ...
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Microcirculatory alterations in ischemia–reperfusion injury and sepsis: effects of activated protein C and thrombin inhibition
... the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study in vivo reduced the extent of transient leukocyte–endothelial-cell interactions (leukocyte ...
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Steroid use in PROWESS severe sepsis patients treated with drotrecogin alfa (activated)
... 23. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein ...
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A case report of a new pulmonary embolism occurring in a patient receiving continuous infusion of recombinant activated protein C
... Recombinant human activated protein C (rhAPC) has been demonstrated to improve mortality in critically ill patients with septic shock ...
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Activated protein C ameliorates impaired renal microvascular oxygenation and sodium reabsorption in endotoxemic rats
... We are aware that our study suffers from some limitations. First, no markers of systemic or renal inflammation or coagulation disorders or oxidative stress were measured. Instead, we merely focused on the acute ...
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Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin
... This prospective observational study conformed to the pro- visions of the Declaration of Helsinki and was approved by the Ethics Committee of Kagoshima University Hospital. Be- tween May 2016 and March 2017, written ...
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Recombinant human activated protein C ameliorates oleic acid induced lung injury in awake sheep
... of protein C was associated with lung injury, upregulation of iNOS, and angiotensin-converting enzyme I/II ratio, all changes that were antagonized by administration of APC ...
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Expression and Immunogenicity of Recombinant Immunoreactive Surface Protein 2 of Anaplasma phagocytophilum
... of recombinant immunodominant proteins of the HGA agent will greatly help to meet the need for diagnostic methods for this ...the recombinant MSP2 was demonstrated by Western blotting using human ...
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Fibrinogen and Fibronectin Binding Activity and Immunogenic Nature of Choline Binding Protein M
... 2015). Recombinant CbpM protein (10 μg/well) was adsorbed in PBS 1x buffer into 96-well po- lystyrene plates (Greinerbio-one, Fricken-hausen, Germany) overnight at ...
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Recombinant human activated protein C: current insights into its mechanism of action
... the protein C system, and in particular APC, plays a central role in the pathogenesis of ...the human in vivo situation and their importance to the treatment of sepsis remain to be ...or ...
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The protein C pathway: implications for the design of the RESPOND study
... plasma protein C level in sepsis has been demonstrated in a number of studies in which depressed protein C levels were associated with increased likelihood of negative ...(Recombinant ...
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The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis
... of recombinant human skel- etal C-protein fragment emulsified in Freund’s adjuvant with heat-inactivated ...of human polymyositis including CD4+ and CD8+ T cell in- ...
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Interlaboratory Optimization and Evaluation of a Serological Assay for Diagnosis of Human Baylisascariasis
... pRSET C/RAG1 expression plasmid. The cultures were incubated at 37°C with shaking at 225 rpm until the optical density at 600 nm (OD 600 ) reached ...the recombinant 6 ⫻ His-tagged RAG1 ...
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