recombinant tumor necrosis factor alpha
Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor alpha in rodents
... gastrointestinal inflammation. Within 30 min gastric emptying was blocked and tissue edema occurred in the small and large intestine. In the cecum hemorrhage occurred after 4 h at doses greater than or equal to 250 ...
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Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways.
... 1265 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest We have recently reported that administration of recombinant tumor necrosis factor alpha TNF-a to hepatitis B virus [r] ...
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Treatment with recombinant human tumor necrosis factor alpha protects rats against the lethality, hypotension, and hypothermia of gram negative sepsis
... of recombinant human TNF-alpha (100 micrograms/kg) to rats undergoing CLP 1 d after the treatment period resulted in a significant reduction in mortality compared to control rats previously unexposed to ...
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Development of a Recombinant Xenogeneic Tumor Necrosis Factor Alpha Protein Vaccine To Protect Mice from Experimental Colitis
... Plasmid construction. Human TNF- ␣ (hTNF- ␣ ) and mouse TNF- ␣ (mTNF- ␣ ) open reading frames (ORF) were purchased from InvivoGen (San Diego, CA, USA). cDNA fragments coding soluble mTNF- ␣ (resi- dues 80 to 235) and ...
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Recombinant human tumor necrosis factor alpha Regulation of N formylmethionylleucylphenylalanine receptor affinity and function on human neutrophils
... concentrations of N-formylmethionylleucylphenylalanine (FMLP). Enhanced superoxide anion production was evident by 5 min and had reached a plateau by 15 min. Not only was the total amount of superoxide anion released ...
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The role of tumor necrosis factor alpha in systemic lupus erythematosus
... In 1988, Jacob and McDevitt [9] reported that NZB/W mice showed diminished production of TNF, a defect stemming from the otherwise healthy NZW parent, and proved that NZB/W disease was at least partly reversible by ...
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Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice
... Among recombinant mouse IFN gamma, human IL1 alpha, human IL2, mouse granulocyte-macrophage colony-stimulating factor and human TNF alpha, only human TNF alpha suppressed insulitis and ...
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Effect of recombinant human tumor necrosis factor alpha on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: role of nitric oxide
... of tumor necrosis factor-alpha in the central nervous system in a rabbit ...of recombinant human TNF into the cisterna magna in the rabbit led to an acute reduction in cerebral oxygen ...
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The 55 kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor alpha and by ultraviolet B radiation
... by recombinant human (rh) TNF ...rhTNF alpha initially decreased, but later increased, 55-kD TNFR surface ...TNF alpha by human keratinocytes, was found to mimic TNF alpha-induced modulation ...
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Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin 25 Mediated Protection from Amebic Colitis
... Recombinant IL-25 treatment. Mice were injected intraperitoneally with 0.5 g recombinant IL-25 (R&D Systems) or 100 l PBS each day for 4 days before and through 4 days after E. histolytica ...
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Dose-effect relationship of CpG oligodeoxyribonucleotide 1826 in murine Lewis lung cancer treated with irradiation
... in tumor volume between the groups before treatment while the tumor volume was remarkably decreased after treatment (P , ...delayed tumor growth for ...the tumor growth delay seen with each ...
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Systemic use of tumor necrosis factor alpha as an anticancer agent
... TNF-α has been proven an effective anticancer agent in in vitro and in vivo preclinical studies. Sadly, the promise of systemic TNF-α has, as of yet, not translated to a patient therapy and enthusiasm has been curbed due ...
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The reduction of CSF tumor necrosis factor alpha levels in schizophrenia: no correlations with psychopathology and coincident metabolic characteristics
... Aim: The aim of this study was to assess whether tumor necrosis factor alpha (TNF-α) levels are correlated with the behavioral syndrome of schizophrenia and/or metabolic abnormalities. ...
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The effect of the pro inflammatory cytokine tumor necrosis factor alpha on human joint capsule myofibroblasts
... The antiproliferative impact of TNF-Į in human HSCs, the MFs of the liver, was previously described to be medi- ated by increased formation of nuclear factor-kappa-B (NF- țB) DNA-binding complexes [29]. ...
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TUMOR NECROSIS FACTOR ALPHA AND INTERLEUKIN 6 IN ESSENTIAL HYPERTENSION
... of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) which might play an important role in the initiation and progression of hypertension by a variety of mechanisms such as giving ...
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Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.
... These classes of inflammatory cells produce an assortment of cytokines, such as tumor necrosis factor alpha TNF-a, alpha interferon IFN-ot, gamma interferon IFN-y, interleukin-1 alpha IL[r] ...
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Tumor Necrosis Factor-alpha (-308 G/A) is a Predictor for Development of Gestational Diabetes Mellitus in Saudi Pregnant Women
... prevalence among saudi women is about 4 to 14% of all pregnancies [14]. Both environmental risk factors and genetic background contribute to the development of GDM. TNF-α increase with pregnancy development and the ...
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Epidermal cytokines: Homeostasis and the regulation of langerhans cell migration and cutaneous immunity
... TNF-a is processed as a membrane-bound protein from which the soluble active factor is derived by cleavage of the extracellular domain by the convertase, TACE (Perez et al, 1990; Moss et al, 1997; Black et al, ...
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Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha Downregulating Genes for the Development of Antituberculous Vaccines
... TNF is arguably the best-established antimycobacterial immuno- logical factor in humans, as reflected by the enhanced susceptibil- ity to M. tuberculosis infection of individuals treated with TNF blockade therapy ...
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DAS 28 based EULAR response and HAQ improvement in rheumatoid arthritis patients switching between TNF antagonists
... Results of a multicenter, randomized, double-blind, placebo- controlled, Phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006, 54:2793-2806. 5. Emery P, Keystone E, Tony HP, ...
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