Redox Homeostasis
Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer
... Cancer cells often encounter increased oxidative stress due to their altered metabolic programs as well as chang- ing microenvironments that induce ROS. Consequently, cancer cells upregulate their antioxidant ...
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Engineering redox homeostasis to develop efficient alcohol-producing microbial cell factories
... GSH is the most abundant non-protein thiol, and is widely distributed in living organisms [80]. It plays important roles in many physiological and metabolic processes, including thiol redox homeostasis, ...
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Thioredoxin like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF κB signaling
... TXNL2 knockdown induces intracellular ROS accumulation. TXNL2 has Trx-like and Grx domains and can rescue the yeast grx3/4 mutant under oxidative stress (data not shown). We thus hypoth- esized that TXNL2 may play an ...
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exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling
... glucose homeostasis (8, ...(redox) homeostasis (10, 11), it is not surprising that redox biology has been proposed as a possible modulator of glycemic control and skeletal muscle adaptation to ...
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Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells
... Despite the aforementioned effects of MSCs on redox homeostasis, it remains to be answered in how far OXPHOS function can be improved in NDUFS4- deficient fibroblasts via MSC treatment. However, for ...
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Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.
... Consistent with our findings that QECs, exposed to high oxygen levels and thus prone to oxidative stress, require FAO to secure redox homeostasis, human QECs expressed higher CPT1A levels in the highly- ...
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Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
... Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism. The genes encoding clock proteins ...
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Perisic, Tamara (2010): Addressing the Role of Mitochondrial Thioredoxin Reductase and xCT in the Maintenance of Redox Homeostasis. Dissertation, LMU München: Fakultät für Biologie
... has been associated with many cardiovascular diseases, including infarction (ischemia/reperfusion injury) and heart failure (Francis, 2001; Griendling and FitzGerald, 2003a; Ide et al., 2000). Ischemia causes alterations ...
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1 4-Hydroxynonenal in Redox Homeostasis of
... Keywords: 4-Hydroxynonenal; lipid peroxidation; redox balance; oxidative stress; stomach; peptic 27.. ulcer; gastritis; Helicobacter pylori; gastric cancer; non-steroid anti-infl[r] ...
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Redox biology of exercise: an integrative and comparative consideration of some overlooked issues
... on redox homeostasis of other tissues is of equal importance considering that exercise affects virtually every tissue of the body in multiple ways (Booth and Laye, ...in redox homeostasis ...
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Molecular Control of Redox Homoeostasis in Specifying the Cell Identity of Tapetal and Microsporocyte Cells in Rice
... of redox status during ...and redox status ...maintain redox homeostasis for normal ...controlling redox status will be elucidated which is crit- ical for both fundamental biology and ...
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Effect of short-term water deficit stress on antioxidative systems in cucumber seedling roots
... maintain redox homeostasis, plants have evolved a complex array of antioxidant defense systems to prevent oxidative in- jury resulting from high levels of ROS, which includes antioxidative enzymes ...
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... various redox-regulatory mechanisms of the cells in order to protect the cells against oxidative stress and the maintenance of the cellular “redox ...
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Oxidative damage parameters in renal tissues of aged and young rats based on gender
... protein redox-homeostasis with renal ...protein redox-homeostasis mechanisms in the aging kidney is ...investigate redox homeostasis as it related to sexual dimorphism on protein ...
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An Analysis of Selected Art Songs for High Voice by Adolphus Hailstork, A Performer's Guide
... maintaining redox balance within the ...the redox states of this subcellular compartment when the cell was exposed to oxidative ...the redox sensor was about 70% oxidized when the glutathione ...
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New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.
... the redox stress: under basal conditions, Nrf2 is ubiquitinylated by Keap1 and Cul3 and targeted for proteosomal ...is redox sensitive and, as a consequence, controls the transcriptional output in function ...
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A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling
... An untested scenario is whether the overexpression of TSPO consequent acute intoxication (e.g., high glutamate level), or similar forms of toxicological stress, may prime alternative ways of cell death in which the ...
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Seven-Up Is a Novel Regulator of Insulin Signaling
... with roles in proteolysis, iron binding, redox homeostasis, metabolism, and immunity. Therefore, although a fraction of genes overlap, many distinct genes related to the same processes were detected with ...
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Manganese Homeostasis in Group A Streptococcus Is Critical for Resistance to Oxidative Stress and Virulence
... It is also established that mutation of high-affinity manganese acquisition systems in S. pneumoniae (46) and GAS (4) leads to reduced growth and survival of these human pathogens in a mouse model of infection. Manganese ...
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Redox regulation of cell proliferation: Bioinformatics and redox proteomics approaches to identify redox-sensitive cell cycle regulators
... Global redox proteomics studies in plants and other photosynthetic organisms: S-Nitrosylation * = endogenous level detection Biological system Methodology Quantification and site identif[r] ...
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