Regulation by post-translational modifications
Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates
... posttranslational modifications, such as SUMOylation, acetylation, O-GlcNAcylation and ADP-ribosylation, are essential modulators of clock proteins, regulating their trans- criptional activity, subcellular ...
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Functions and regulation of Hdmx and post-translational modifications in drug sensitivity and cancer.
... chemotherapy. Post-translational modifications in the p53 pathway: Cross-talk on the ...The regulation of p53 levels and activity is mainly at the protein level; changes in protein stability ...
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Intrinsically disordered proteins link alternative splicing and post-translational modifications to complex cell signaling and regulation
... splicing, post-translational modification, differential and context-dependent signaling, signaling modulation, and regulation Abbreviations: IDPs or IDRs, intrinsically disordered proteins or ...
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Regulation of pannexin channels by post-translational modifications
... tight regulation of channel opening is necessary to modulate their function in ...vivo. Post- translational modifications have been postulated as some of the regulating mechanisms for Panx1, while ...
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Regulation of gene silencing: From microRNA biogenesis to post-translational modifications of TNRC6 complexes
... suggested that TNRC6 may act as binding platform for different nuclear processes such as splicing and transcription. However, this assumption is speculative and relies on proteomic screens which were performed lacking ...
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Quantitative protein expression profiling reveals extensive post transcriptional regulation and post translational modifications in schizont stage malaria parasites
... gene regulation and many instances of proteins that occur in multiple isoforms that are probably due to PTMs and/or pre-translational events, such as alternative splicing or transcription ...that ...
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Covalent Post Translational Modifications
... posttranslational modifications in red line connects the host proteins ability to undergo ptms and the ...covalent post modifications of cellular state of dmvs, specificity of all cells are related ...
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Event Extraction for Post Translational Modifications
... separate Regulation events to capture ...Positive regulation and the other a Nega- tive regulation event), reducing the sparseness of specific event structures in the data, and matching the ...
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Post-translational modifications and mass spectrometry detection
... redox regulation of enzyme activity has been ...redox regulation is determined by the chemistry of its thiol ...in regulation of the activity of several signalling proteins ...
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Does Lysozyme Have Post Translational Modifications
... to modifications and post your ...and post your interest is lysozyme peak from sigma chemical ...such modifications have helped handling the lysozyme and post your protein express assay ...
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An investigation into the post-translational modifications of Annexin VI
... Chapter 5 Discussion 5.1 Why Investigate Annexin VI Phosphorylation? The impetus for studying annexin VI phosphorylation was based on the knowledge that in numerous instances, protein phosphorylation is an important ...
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Proteomics of protein post translational modifications implicated in neurodegeneration
... 3.3 Signalling through receptors and kinase cascades, the secretome and roles of protein cleavage We use the term signalling here in the context of pathways relevant to neurobiological function including, but not limited ...
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Post translational modifications of HOX proteins, an underestimated issue
... coordinated regulation of target genes by HOXA9 and HOXA10 in myelopoiesis, with distinct effects of their phosphorylated status with regard to their DNA binding but also their ability to activate target genes ...
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Functional role of post-translational modifications of Sp1 in tumorigenesis
... results indicate that Sp1 is an ATM substrate that plays a role in the cellular response to DNA damage. Ser101 phosphorylation did not affect transcriptional activity from the Sp1 responsive promoter, but it did promote ...
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Enhanced top down characterization of histone post translational modifications
... detect modifications up to K20 within the N-terminal ...epigenetic regulation of specific target genes, further highlighting the need for top- down analysis of histone ...
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Coordinated of Post-Translational Modifications of Yeast Transcriptional Activator Gcn4
... 17 of the PIC and thus triggering transcription during amino acid deprivation (Ptashne & Gann 1997; Brzovic et al., 2011). Although the Gcn4 protein plays an important role in many biological functions, its ...
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Post-translational modifications of RINT1 (RAD50-interacting protein 1)
... 71 3.2.3. RINT1 is also polyubiquitinated by K29- and K63-linked chains The finding that RINT1 is markedly ubiquitinated with or without addition of MG132 (Fig. 15), suggested the existence of additional ubiquitination ...
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Lysine Post-Translational Modifications of Saccharomyces Cerevisiae Chromatin Proteins
... Cdc28 was similarly abundant in the different phases as expected whereas Clb2, a G2- M marker, was most abundant with Nocodazole treatment and undetectable with Alpha Factor treatment. WCEs were then loaded into protein ...
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Dual Coordination of Post Translational Modifications in Human Protein Networks
... mRNA regulation, predominantly through modification of spliceosomal and ribosomal sub-complexes (Grey boxes, Figure ...functional regulation for each modification supporting our approach to PTM complex ...
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Evolution and functional cross-talk of protein post-translational modifications
... seen for cell-cycle kinases (Alexander et al, 2011). While new PTM types arise only rarely and PTM domain sub- families and specificity diverge by duplication and divergence, new PTM sites and interactions have much ...
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