REGULATORY REGIONS
HiCoP, a simple and robust method for detecting interactions of regulatory regions
... whether regulatory regions are specifically enriched in CoP chromatin, we detected an enhancer (T cell receptor gene Tcra enhancer Eα in mouse thymocytes), three promoters (active gene GAPDH promoter in ...
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A statistical thin-tail test of predicting regulatory regions in the Drosophila genome
... The identification of transcription factor binding sites (TFBSs) and cis-regulatory modules (CRMs) is a crucial step in studying gene expression. The computational methods of predicting CRMs from non-coding ...
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Genetic variants in regulatory regions of microRNAs are associated with lung cancer risk
... In recent years, comprehensive analyses based on genome-wide association studies (GWAS) have indicated that disease/trait-associated loci are enriched in the genomic regulatory regions [25–27]. Thus, it is ...
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Identification of regulatory regions of bidirectional genes in cervical cancer
... promoter regions (Figure ...the regulatory region of each gene, the overlaps of regulatory regions of 249 gene pairs are shown in Figure ...ulatory regions were found for 55 pairs of ...
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Computational Methods for Identifying and Characterizing the Human Gene Regulatory Regions and Cis-elements
... CNS regions of three species and all CNS regions obtained from one species compared with two other species ...noncoding regions that maximize number of overlapping regions, and minimize number ...
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Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice
... gene regulatory regions, and/or the human regulatory regions present in the BAC being non-functional in the mouse ...important regulatory elements reside in these differential ...
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Analysis of transcriptional regulatory regions in vivo
... transcriptional regulatory regions and the great molecular distance these regions may reside from the transcribed ...control regions present at the chromosomal inte- gration ...control ...
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Evolution of cis regulatory regions versus codifying regions
... of regulatory motifs can affect tran- scription in other ...noncoding regions, owed to their overall greater sequence ...new regulatory modules to other cis-regulatory ...lack ...
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Evolution of DNAase I Hypersensitive Sites in MHC Regulatory Regions of Primates
... Additionally, regulatory variants have been linked to the susceptibility to various human diseases outside the MHC region, including infectious, autoimmune, psychiatric, neo- plastic, and neurodegenerative ...
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Molecular Evolution of Duplicated Amylase Gene Regions in Drosophila melanogaster: Evidence of Positive Selection in the Coding Regions and Selective Constraints in the cis-Regulatory Regions
... Figure 4.—Sliding window plot of the nucleotide diversity, , of the two populations ( JP and KN) and the nucleotide divergence be- tween D. melanogaster and D. sim- ulans, (interspecific), across the Amy gene ...
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MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis
... the regulatory network that in- cludes all nodes ...direct regulatory elements) ...the regulatory neighbors of the target gene (see ...the regulatory network and the DRE-target pair (see “ ...
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Four distinct regulatory regions of the cut locus and their effect on cell type specification in Drosophila.
... II alleles, the Malpighian tubules are missing and are replaced by a thickening in the wall of the gut. The mutant structure can be identified as transformed Malpighi[r] ...
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Regulatory regions of the homeotic gene proboscipedia are sensitive to chromosomal pairing.
... If these gene products interact with the p b PS sites, an enhancement or repression of white expression could be expected in transformants carrying a p b PS region[r] ...
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Identification of regulatory regions that determine expression of the murine CD8 locus
... (D em bic et a l , 1986, K appler et al., 1983). T cell receptors, like im m unoglobulins, have variable and constant regions. However, the m ain difference betw een B and T lym phocyte receptors is that the cell ...
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Interactions of Drosophila Ultrabithorax Regulatory Regions With Native and Foreign Promoters
... These authors report that in larvae carrying a construct of 35 kb of Ubx upstream regulatory region fused to the lac2 gene there is p- galactosidase protein in the post[r] ...
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The Pygo2 H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling dependent transcription
... transcriptional regulatory function of ...the regulatory regions of several genes (both Wnt targets and others) ...the regulatory regions: we arbitrarily designed primers spanning the ...
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Primer Pairs for Rice (Oryza sativa L.) Bisulfite Sequencing Studies
... Occurrence of GC, GHG and GHH islets among sucrose phosphate synthase, 3-hydroxy- 3-methylglutaryl-CoA reductase, BP-73 gene for SAP-like protein, tub A2 gene for tubulin alpha, promoter region and 5’- UTR of CDPK2, tub6 ...
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DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis
... Subsequently, regulatory regions mapping to upregulated or downregulated genes were further sub- divided according to transitions in Pc-binding at each of their associated taGATCf ([r] ...
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The search for cis -regulatory driver mutations in cancer genomes
... determine regulatory regions that are recurrently ...promoter regions with more mutations than expected by chance alone ...the regions focused upon in analysis demonstrates the need for the ...
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The Origin of Subfunctions and Modular Gene Regulation
... a regulatory region may facilitate the formation there are two ancestral A sites to lose, four (two B and and preservation of two fully independent regulatory ele- two C) sites may be ...duplicate ...
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