Regulatory T cell (Treg)
Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy
... assessed using the Novolink Kit (Menarini Diagnostics, RE7140-K). FFPE cancer tissue sections were deparaffinized for antigen retrieval and then rehydrated through graded alcohols to water. Antigen retrieval was carried ...
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Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3
... novel Treg regulatory mole- cules with differential expression were revealed here and original findings relevant for human immunology are discussed below, both from a global genomic perspective and a ...
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
... from Treg cells present in a naïve mouse, confirming that pathogen-specific Treg cells exist in the steady state and proliferate after encountering cognate Ag (Shafiani et ...of Treg cells expressing ...
158
Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell Function
... of regulatory T cells (59, ...Foxp3+ Treg function ...opposes Treg suppressive function both in vitro and in vivo, but did not determine a mechanism by which CDK2 acts in Tregs ...controls ...
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Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high dose interferon α 2b treatment
... Patients with stage III and IV operable and inoperable melanoma who were referred to the National Cancer Institute of Naples from July 2006 to December 2008 were enrolled to receive treatment with IFN- a 2b. The study ...
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Increased activated regulatory T cell subsets and aging Treg-like cells in multiple myeloma and monoclonal gammopathy of undetermined significance: a case control study
... activated Treg cells (aTregs), resting Treg cells (rTregs) and non-suppressive Treg cells (non-Tregs) [8, ...aTreg cell which has a stronger immunosuppressive function than rTreg cell ...
8
Toll like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease
... cells; Treg: regulatory T cell; TLR: Toll-like receptor; CD: Crohn ’ s disease; UC: ulcerative colitis; DNBS: dinitrobenzene sulfate; DSS: dextran sodium sulfate; PRRs: pattern recognition ...
8
Serum IFN γ levels predict the therapeutic effect of mesenchymal stem cell transplantation in active rheumatoid arthritis
... and T lymphocytes [5] to induce regulatory T cell (Treg) dif- ferentiation and inhibit T helper 17 (Th17) cell func- tion [6]; it is through these mechanisms that MSCs ...
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Regulatory T Cells Promote Early Influx of CD8+ T Cells in the Lungs of Respiratory Syncytial Virus-Infected Mice and Diminish Immunodominance Disparities
... natural regulatory T (Treg) cells are global regulators of adaptive immune ...ⴙ T-cell responses were enhanced in Treg-cell-depleted mice at all time points following ...
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Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos
... the regulatory T cell (Treg), responder CD4+ T helper cell (Tresp), CD8+ cytotoxic T lymphocytes (CTL), and natural killer (NK) cells were ...of regulatory T ...
7
Autophagy enhances mesenchymal stem cell-mediated CD4+ T cell migration and differentiation through CXCL8 and TGF-β1
... T cell recruitment and differentiation can be used to assess the efficiency of MSC-mediated ...+ T cell migration through ...+ T cell recruitment enhanced by autophagy plays a ...
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Changes in plasma EBV-DNA and immune status in patients with nasopharyngeal carcinoma after treatment with intensity-modulated radiotherapy
... paired t test was used to com- pare the indexes between the pretreatment and post-treatment groups when the data were normally distributed; otherwise, the Wilcoxon signed-rank test was ...
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Y27, a novel derivative of 4 hydroxyquinoline 3 formamide, prevents the development of murine systemic lupus erythematosus like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice
... defective Treg cell function ...effector T cells through its soluble forms, or its direct contact with Tregs, which display TGF-b on their surface ...When cell-to-cell contact takes ...
13
How to detour Treg cells in T cell-based antitumor immune therapy
... of Treg cells or other immune suppressive cells in peripheral blood may provide the clue for prediction of tumor volume and therapeutic ...ing Treg cells in response to delivery of the killer ...the ...
5
The clinical importance of changes in Treg and Th17 lymphocyte subsets in splenectomized patients after spleen injury
... 25 ng/mL of phorbol 12-myristate 13-acetate (PMA, Sigma Chemical, St. Louis, USA) and 1 μg/mL of ionomycin (Sig- ma Aldrich) in the presence of 10 μg/mL of brefeldin A (Sig- ma-Aldrich), which blocks the intracellular ...
8
Extract from mango mistletoes Dendrophthoe pentandra ameliorates TNBS induced colitis by regulating CD4+ T cells in mesenteric lymph nodes
... Results: MMDP extract potently suppressed colon shortening and MPO in mice with TNBS-induced colitis. Administration of the extract significantly decreased the severity of TNBS-induced colitis in a dose-dependent manner. ...
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Analysis of lymphocytes in patients with Plasmodium vivax malaria and its relation to the annexin A1 and IL 10
... Results: The cytokine IL-10 plasma levels showed a significant increase in both patients with low (650.4 ± 59.3 pg/mL) and high (2870 ± 185.3 pg/mL) parasitaemia compared to the control (326.1 ± 40.1 pg/mL). In addition, ...
7
Mechanisms of allergen-specific immunotherapy
... Th2 shift is established, the mechanism of allergic dis- eases consists of two main phases. In the early phase sensitization and the development of memory cells takes place. The late phase is characterized by ...
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Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells
... + T cells by Jagged-1 resulted in increased expression of CD25 and FoxP3 ...in Treg induction and the high expression by MSC, Jagged-1 was chosen for targeted in- hibition ...+ T cells to determine ...
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Transplant trials with Tregs: perils and promises
... of Treg and Teff responses in vivo and found that Teffs arrive at the graft site first and expand in number before the arrival of Tregs (22); thus, the grafts are dominated by Teffs and are quickly ...affecting ...
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