Renal Fibrosis
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice
... administration of neuroprotective agents, such as dexamethasone and neurotrophins. Moreover, the in vivo administration of tamoxifen, a selective estrogen receptor modulator, restored attenuated erythropoietin production ...
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Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis
... preserve renal function in early stage genetic mouse strains with PKD1 mutations [45] and ameliorates renal inflammation ...on renal fibroblast activation and renal fibrosis development ...
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Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
... during renal fibrosis is tightly regulated by TGF-β1 via the Smad3, but not Smad2, dependent mechanism [78-80], which is also illustrated in Figure ...
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Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review
... of renal outcomes to be able to capture the maximum number of biomarkers of fibrosis assessed in the ...with fibrosis on biopsy and were associated with renal ...of fibrosis and ...
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A nonclassical vitamin D receptor pathway suppresses renal fibrosis
... disease, renal fibrosis is a promising treatment ...addition, renal fibrosis is often asso- ciated with inflammatory infiltration of monocytes and macro- phages, which are essential for the ...
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Impact of heparanase on renal fibrosis
... of renal fibrosis (glo- merulosclerosis, TIF, inflammatory infiltration, and loss of renal parenchyma, characterized by tubular atrophy, capillary loss, and podocyte depletion) are caused by sev- ...
7
Endoplasmic Reticulum Stress Implicated in the Development of Renal Fibrosis
... as XBP-1 expression, may lower cellular protection. On the other hand, the down- streams signals of IRE1α, such as activa- tion of caspase-12 and JNK, help initiate ER stress–mediated apoptosis (8,18,35). In this work, ...
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Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin
... A mouse model of UUO was established in C57BL6 male mice (6 weeks of age, 20-22g) by ligating the left ureter as previously described [11]. Animals were randomly divided into 5 groups including Sham, UUO with vehicle ...
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In vivo bradykinin B2 receptor activation reduces renal fibrosis
... fibrotic renal diseases both in humans and in animal ...accelerated renal tubulointerstitial fibrosis that is attenuated by ACE ...in renal fibrosis has not been ...interstitial ...
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The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis
... kidney fibrosis in adult male Wistar rats submitted to subtotal nephrectomy ...the renal fibrosis score throughout the 120 observation days (r = ...
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Analysis of renal fibrosis in a rabbit model of crescentic nephritis
... elevated by day 3, peaked at days 7-15, and returned towards baseline by day 21. Collagen content of both glomeruli and cortex were increased starting on days 14-16, and remained constant in cortex thereafter. Light ...
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Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease
... lointerstitial fibrosis (6, 7). All the renal tissues were fixed in neutral buffered formalin, except for fixation with 70% ethanol to detect TGF- b and embedded in ...
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Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
... Present studies on the role of KLF15 in kidney biology mainly focus on podocyte injury, mesangial pathology, and renal fibrosis. In this review, we have introduced several major functions and the ...
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Original Article Pax2 expression correlates with EMT markers in an experimental model of obstructive nephropathy
... after renal injury to limit apoptotic dam- age ...protects renal col- lecting duct cells against apoptosis that would typically be induced by obstructive injury ...the renal tubular epithelial ...of ...
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No difference in renal injury and fibrosis between wild-type and NOD1/NOD2 double knockout mice with chronic kidney disease induced by ureteral obstruction
... tubulointerstitial fibrosis and inflammation nor in the progression of renal damage after UUO-induced ...of renal fibrosis in NOD1/2 DKO ...and renal in- jury by inducing inflammation ...
8
Original Article Tannins from pomegranate seeds ameliorate renal injury in streptozotocin-induced diabetic rat through the activation of microRNA-495 via regulating SMAD7
... on renal in- jury in streptozotocin (STZ)-induced experimentally type 1 diabetic ...on renal fibrogenesis was investigated, and the down-regulation of E-cadherin and the up-regulation of α-SMA in kidney ...
9
RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase
... Renal fibrosis is a common pathogenic response to injury in chronic kidney disease ...(AD-induced) renal fibrosis, models of progressive kidney fibrosis, we demonstrate increased kidney ...
15
Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
... against renal diseases was not yet ...hepatic fibrosis induced by carbon tetrachloride, one compound that could reduce a-SMA expression and collagen syn- thesis ...of renal diseases. For instance, in ...
7
Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition
... consequently renal fibrosis ...many renal dis- eases, playing an important role in diabetic neuropathy, acute kidney injury, polycystic kidney disease, glomeru- lopathy, intrarenal inflammation, and ...
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Grigorescu Vlass, Melissa (2018): Inflammasome-independent NLRP3 signaling in chronic kidney disease. Dissertation, LMU München: Medizinische Fakultät
... of renal interstitial fibrosis by regulating TGF- β signaling in an inflammasome-independent ...from renal interstitial fibrosis compared to Nlrp- 3-deficient ...
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