Renal tubular damage and cellular dysfunction
RENAL TUBULAR DAMAGE IN INFANTILE GASTRO-ENTERITIS
... %; this rise coincided with a rise in the protein intake and was not associated with dehydration nor did it appear that glomerular insufficiency was responsible, as a urea clearance five[r] ...
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Tenofovir is associated with increased tubular proteinuria and asymptomatic renal tubular dysfunction in Ghana
... active tubular secretion, with uptake in the proximal tubule and secretion into the tubular space ...favourable renal safety profile [21, 22], however there were rare post- marketing reports of ...
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Tubular overexpression of gremlin induces renal damage susceptibility in mice
... 4 Cellular Biology in Renal Diseases Laboratory, Universidad Auto´noma Madrid, Madrid, Spain Abstract A growing number of patients are recognized worldwide to have chronic kidney ...human renal ...
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UT-B-deficient mice develop renal dysfunction and structural damage
... in renal morphology have been seen in aquaporin-null mice, which exhibit polyuria as a result of increased intrarenal pressure ...the renal cortex and medulla, which may result from long-term polyuria, ...
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Cofilin1 is involved in hypertension induced renal damage via the regulation of NF κB in renal tubular epithelial cells
... Quan‑zhen Wang 1 , Hai‑qing Gao 1 , Ying Liang 2 , Jun Zhang 1 , Jian Wang 1 and Jie Qiu 1* Abstract Background: Inflammation mediated by nuclear factor‑κB (NF‑κB) plays a critical role in the pathogenesis of hyper‑ ...
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NGAL protects against endotoxin-induced renal tubular cell damage by suppressing apoptosis
... of renal NGAL mRNA from 3 to 12 h after treatment compared with controls (p < ...rat renal epithelia cells, we se- lected the 6 h time point post-LPS treatment to evaluate NGAL and kidney ...
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Ischemic acute renal failure and antioxidant therapy in the rat The relation between glomerular and tubular dysfunction
... J Clin Invest. 1988;81(5):1630-1638. https://doi.org/10.1172/JCI113498. The effects of antioxidant therapy with probucol were evaluated in rats subjected to 1 h renal ischemia and to 24 h reperfusion. Probucol ...
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The Pnh3 of Renal Tubular Cells
... spiratory and acute metabolic acidosis, renal pro- duction of ammonia is unchanged, cellular PNH3 is reduced, and a portion of the ammonia usually added to renal venous blood is now excr[r] ...
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Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model
... Major limitations of our study were that we compared an iso- oncotic 6% HES 130/0.42 solution (in vitro COP 37.8 mmHg) with a hyperoncotic 10% HES 200/0.5 solution (in vitro COP 80 to 85 mmHg), thus we cannot ...
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Quantifying cellular mechanics and adhesion in renal tubular injury using single cell force spectroscopy
... specific and non-specific adhesions. Figure 4, B, shows the changes in elasticity between the two groups of treatments, and is the culmination of processing more than 150 curves for each treatment obtained from 5 ...
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Endonuclease induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells
... DNA damage and cell death have been attributed to the direct cytotoxicity of H2O2 and other oxidant species generated from ...DNA damage and cell death in renal tubular epithelial cells, ...
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Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage
... enrolled. Renal diseases included the following: IgA nephropathy (IgAN; n = 25; males/fe- males, 13/12; age, ...of renal biopsy specimens, and through the results of immunoglobulin and complement deposition ...
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Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy
... on renal cell mitochondrial metabolism, but the mechanisms by which this was caused remains ...chain. Dysfunction in mitochondrial metabolism could be caused by the direct effect of the glucose through ...
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Intragraft transcriptional profiling of renal transplant patients with tubular dysfunction reveals mechanisms underlying graft injury and recovery
... and maintenance of an epithelial phenotype in tubular cells [48]. Conclusions This study showed that increased retinol-binding pro- teinuria is associated with kidney function worsening in renal transplant ...
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Evaluation of Urinary Tubular Enzymes as Screening Markers of Renal Dysfunction in Patients Suffering from Diabetes Mellitus Type 2
... Diabetes mellitus ty p e 2 patients show elevated levels of albumin in urine and assessment of renal injury based on the concentrations of blood urea nitrogen (BUN), serum creatinine (S.[r] ...
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Impaired Proteostasis Contributes to Renal Tubular Dysgenesis
... of renal tubular dysgenesis (RTD) is linked to mutations in the angiotensin- converting enzyme ...of cellular proteostasis by temperature shift causes an extension in the processing time and ...
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Renal damage associated with proteinuria
... Renal damage associated with proteinuria M ANUEL P RAGA and E NRIQUE M ORALES Servicio de Nefrologı´a, Hospital 12 de Octubre, Madrid, Spain Renal damage associated with ...proximal ...
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Clinicopathological Spectrum of Renal Allograft Dysfunction.
... and tubular epithelial cells and leads to ...the renal tubules and causes ...through renal tubular basement membrane, there they proliferate and cause apoptosis of the tubular ...
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Renal dysfunction in chronic liver disease
... from tubular cells damaged by ischemia impairs reabsorption of sodium, which polymerizes Tamm-Horsfall proteins form ing a gellike substance that occludes the tubule causing increased backpressure and ...further ...
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RENAL TUBULAR DYSFUNCTION COMPLICATING THE NEPHROTIC SYNDROME
... phrotic syndrome.9 No data are available on the excretion of amino acid in the urine of the present patients during the early part of their disease; .nevertheless, it is known that they [r] ...
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