Repair Proteins
FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication
... Fanconi anemia patients have an inherent susceptibility to HPV-associated malig- nancies, suggesting that the loss of FA pathway activity promotes oncogenesis (48); however, the role that the FA pathway plays during ...
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Repair of traumatized mammalian hair cells via sea anemone repair proteins
... Fig. 2. Effects of anemone RPs on morphology of hair bundles of OHCs. Specimens were treated as described in the legend for Fig. 1 and then fixed and processed for F-actin cytochemistry using a fluorescent derivative of ...
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Distinct Roles for the Saccharomyces cerevisiae Mismatch Repair Proteins in Heteroduplex Rejection, Mismatch Repair and Nonhomologous Tail Removal
... migration repair of the mismatch using the parental strand as a enzymes are capable of promoting recombination be- template (Modrich and Lahue 1996; Schofield and tween DNA sequences that display up to 10% ...
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Global Genome Nucleotide Excision Repair Proteins Rhp7p and Rhp41p Are Involved in Abasic Site Repair of Schizosaccharomyces pombe
... nize and directly bind to AP sites, a protein-protein interaction seems to be important for the stimulation of DNA glycosylases by XPC, rather than competition for AP sites [42]. We showed that Rhp41p synergistically ...
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1 Small molecule docking of DNA repair proteins
... docking, drug- and lead-like filtering of docked ligands, and computational toxicology and ADME 385. predictions[r] ...
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DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication
... the repair of DNA replication errors and the maintenance of genomic stability (20, ...MMR proteins play key roles in nonrepair mechanisms as well ...MMR proteins play an as-yet-undefined role in ...
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Elucidating the Role of [4Fe4S] Clusters in DNA Replication and Repair Proteins
... search for damage across a vase genome (8, 14-15). If there is no DNA damage between the two binding sites, the charge transfer can proceed efficiently, and one of the DNA-bound proteins is reduced, thus its ...
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Chromatin structure and DNA damage repair
... DNA-interacting proteins to chromatin and it is a versatile control mechanism in all nuclear processes ...DSB repair, including SWR1, RSC, INO80, Rad54 and SWI/SNF ...DNA repair proteins such ...
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C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response
... with proteins that function in DDR pathways and in RNA processing events as well as in the induction of apoptosis position it as an ideal candidate to coordinate processes that main- tain genomic stability ...DSB ...
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Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?
... DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glyco- sylase 1 [SMUG1], Flap endonuclease 1 [FEN1], X-ray repair ...
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Genetic requirements for the targeted integration of Agrobacterium T-DNA in Saccharomyces cerevisiae
... Xrs2 proteins are required for T-DNA integration by NHR ...Rad52 proteins, which are exclusively involved in HR (12), were found to be dispensable for the integration of T-DNA by NHR ...DNA repair ...
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Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair
... from MM patients, which was higher than that of bendamustine and independent of the p53 status and previous melphalan resistance. This activity was confirmed in vivo, in a CB17-SCID murine plasmacytoma model and in de ...
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Emergence of a daptomycin non susceptible Enterococcus faecium strain that encodes mutations in DNA repair genes after high dose daptomycin therapy
... Notably, by comparing the genomes of the two E. fae- cium isolates, we detected mutations that were present in the genes encoding the DNA repair proteins MutL (mutL) and RecJ (recJ) of the DNSE strain, but ...
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Stimulation of Homology-Directed Repair at I-SceI-Induced DNA Breaks during the Permissive Life Cycle of Human Cytomegalovirus
... DNA repair proteins, thereby avoiding a poten- tially detrimental damage ...homology-directed repair (HDR) ...break repair assay was used to determine that HCMV stimulated HDR. Repair ...
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DNA damage induces nuclear translocation of parkin
... nuclear proteins involved in DNA ...DNA repair proteins trig- gered through DNA damage-mediated ...DNA repair [28,29]. These results suggest that parkin pro- motes DNA repair and ...
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Magnetic Field Effects and Biophysical Studies on DNA Charge Transport and Repair
... Many repair mechanisms have evolved to uphold genome integrity by repairing DNA damage caused by oxidative stress ...DNA repair systems utilize diverse teams of proteins to respond, search, and ...
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Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients
... DSB repair proteins in CRC ...DSB repair and CRC is limited and contro- versial, particularly regarding Ku70 and ATM coexpression with poor disease-free survival ...DNA repair proteins ...
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The archaeal RecJ like proteins : nucleases and ex nucleases with diverse roles in replication and repair
... for proteins that interacted with the intrinsically disordered region (IDR) that separates the N-terminal helicase and C-terminal nuclease domains of the TkoHef protein ...HAN proteins are found across the ...
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Muscle membrane repair and inflammatory attack in dysferlinopathy
... receptors) proteins [27] and synaptotagmins (Syt), transmembrane proteins with two highly conserved C2 domains that may serve as calcium sensors in the regulation of vesicle exocytosis in neurons and other ...
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Evolutionary Rate Covariation in Meiotic Proteins Results from Fluctuating Evolutionary Pressure in Yeasts and Mammals
... interacting proteins; it is signifi- cantly elevated between many noninteracting, functionally related proteins such as metabolic enzymes and distant members of protein complexes (Hakes et ...all ...
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