Replication in the brain
Ultrastructural Analysis of ICP34.5− Herpes Simplex Virus 1 Replication in Mouse Brain Cells In Vivo
... normal brain cell types in vivo is poorly ...mouse brain cell ...normal brain cells in animal models is needed to enhance our understanding of the risks associated with the use of current and future ...
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Role of Microglial Cells in Selective Replication of Simian Immunodeficiency Virus Genotypes in the Brain
... the replication of specific genotypes in the brain and, more specifically, in the ...the brain, and from peripheral blood mononuclear cells (PBMC) isolated from blood at the time of ...the ...
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Theiler's virus replication in brain macrophages cultured in vitro.
... 3188-3193 0022-538X/92/053188-06$02.00/0 Copyright © 1992, American Society for Microbiology Theiler's Virus Replication in Brain Macrophages Cultured In Vitro MARTINE LEVY,* CHRISTINE A[r] ...
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Development of Neurological Disease Is Associated with Increased Immune Activation in Simian Immunodeficiency Virus-Infected Macaques
... virus replication in the brain appeared to outpace that outside the CNS, as observed with significantly higher viral loads (1- to 2-log steps) in the CSF versus plasma at the time of death of animals with ...
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Blood borne transit of CJD from brain to gut at early stages of infection
... Abnormal PrP accumulation is a sign of agent invasion. Because ileal Peyer's patches were insufficient for West- ern blotting analysis of PrP change, and could not be cleanly dissected, we used in situ methods that ...
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Susceptibility and resistance to poliovirus-induced paralysis of inbred mouse strains.
... We were unable to correlate H-2 haplotype with high disease incidence, virus replication in the brain or spinal cord, neutralizing antibody or ELISA antibody responses, or TPRLF response[r] ...
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Baxter-Heise2018_Article_GeneticControlOfAlphavirusPath.pdf
... viral replication in the brain, clinical encephalitis, and death, indi- cating that IRF2, an ISG that negatively regulates IFN sign- aling, protects mice from neuroinvasion through promotion of immune cell ...
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Development of a model of Saint Louis encephalitis infection and disease in mice
... acute brain inflammation, corroborating previous reports [22, ...SLEV replication in the brain triggers the local production of proinflammatory cytokines that ultimately causes SLEV- induced ...
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Passive Immunization Reduces Murine Cytomegalovirus-Induced Brain Pathology in Newborn Mice
... developing brain by both direct neutralization of the virus or by mechanisms which clear virus-infected cells such as antibody -dependent cellular ...virus replication in the brain, were also ...
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Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis
... VSV replication in the brain neurons and prevents neuro- ...virus replication in neu- rons in all regions of the brain, in spite of strong induction and action of IFN-  , indicating that, ...
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Differential Replication of Pathogenic and Nonpathogenic Strains of West Nile Virus within Astrocytes
... of brain endo- thelial cells and astrocytes establish a tighter barrier than endothe- lial cells alone, and secretion and activation of matrix metalloproteases (MMPs) by astrocytes result in disruption of the BBB ...
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Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1.
... viral replication, such as necrosis or inclusion bodies ...the brain stem, but not thereafter, although the number of macrophages and/or activated micro- glia remained minimally elevated up to 9 months ...
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Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1
... viral replication in neurons, simi- lar to LGTV-infected TLR7 −/− mice brains ...the brain and when activated could act as potential source of proinflammatory ...the brain contributed to ...
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Circuit-Specific Coinfection of Neurons in the Rat Central Nervous System with Two Pseudorabies Virus Recombinants
... and replication in single- and dual-injection paradigms is ...the brain that receive visual ...the brain (11). (Right panel) Caudal brain stem neurons involved in the regulation of visceral ...
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Human Immunodeficiency Virus Type 1 Infection Increases the In Vivo Capacity of Peripheral Monocytes To Cross the Blood-Brain Barrier into the Brain and the In Vivo Sensitivity of the Blood-Brain Barrier to Disruption by Lipopolysaccharide
... the brain, particularly after partial compromise of the BBB in response to LPS treatment, and indicate the applicability of these mice as an in vivo system to study the mechanism by which HIV-1-infected monocytes ...
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Interferon Regulatory Factor 3-Dependent Pathways Are Critical for Control of Herpes Simplex Virus Type 1 Central Nervous System Infection
... amining replication in corneas, trigeminal ganglia, and periocular skin (data not shown), but there are also some sharp distinctions when considering the current observation of in- creased lethality and ...
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Macrophages sustain HIV replication in vivo independently of T cells
... This work was supported in part by grants from the National Insti- tute of Allergy and Infectious Diseases (NIAID) (AI-096113 and AI-111899) and the National Institute of Mental Health (NIMH) (MH-108179). J.B. Honeycutt ...
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Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
... support replication of highly infectious PrP Sc with assistance of cofactors of polyanionic nature and/or ...by brain-derived PrP Sc gave rise to new prion strains with new disease phenotypes documenting ...
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Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis.
... Viral replication, apoptosis, and tissue damage are restrict- ed to distinct regions within the neonatal mouse ...the brain as reovirus replication and tissue injury, brain tissue sections ...
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Brain structural networks and connectomes: the brain–obesity interface and its impact on mental health
... Results: The diffusion indices of the posterior limb of the internal capsule, corona radiata, and superior longitudinal fasciculus were significantly lower among obese subjects when compared with controls. Moreover, ...
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