replication stress
Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress
... resolve replication stress leads to a rampant increase in chromosomal abnormalities and cancer heterogeneity ...of replication stress, and in its absence, RAD51 is not recruited, lead- ing to ...
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Establishing DNA combing to investigate DNA replication stress in vitro
... the Replication Initiation Capacity of Recombinant Cyclin A/CDK2 Results shown earlier display that in in vitro replication assays an N terminal fragment of Ciz1 can alter the kinetics of DNA ...
108
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
... DNA replication stress and genomic in- stability [26, ...for replication-associated damage in triggering the transcriptional response to APOBEC3 ...DNA replication stress- invoked ...
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Human CDK18 promotes replication stress signaling and genome stability.
... efficient replication stress signaling, how this ac- tivity specifically regulates such signaling is presently un- ...of replication stress ...
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The Drosophila Werner Exonuclease Participates in an Exonuclease-Independent Response to Replication Stress
... during replication stress does not depend on exonuclease activity, suggesting that it acts as part of a larger protein complex to respond to stalled or collapsed replication ...
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RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability
... simulate replication stress, we subjected WT-B8 and VF-B8 cells to low-serum conditions to deprive cells of de- oxynucleotide triphosphate (dNTP) (Bester et ...endogenous replication stress ...
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Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs
... and was confirmed to have no effect on cell survival. Cisplatin (Sigma) stock solution was prepared in physi- ological solution and diluted to applied final concentra- tion. U251 or NCH421k cells or primary GSC cells ...
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Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase
... stalled replication forks (Alcasabas et ...by replication stress in which repli- cation forks bypass the lesion, leaving ssDNA gaps behind (Sun et ...
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DNA replication stress underlies renal phenotypes in CEP290 associated Joubert syndrome
... CEP290 depletion causes DNA damage ex vivo, in vitro, and in vivo. Recent studies have implicated DDR and sensitivity to replication stress in the development of ciliopathies. To explore the breadth of ...
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Targeting Mcl 1 enhances DNA replication stress sensitivity to cancer therapy
... DNA replication stress led to formation of γ-H2AX DSB foci in MEFs expressing Mcl-1 WT or various dele- tion mutants (Figure 7B, left ...DNA replication stress–induced DSBs mainly occurs ...
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Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
... RINGs are dependent upon regulator of replication stress ATR. We hypothesised that RINGs signal activation of ATR that counteracts DNA replication stress by phosphorylating diverse substrates ...
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Impact of Replication Stress in Human Papillomavirus Pathogenesis
... THE REPLICATION STRESS RESPONSE FOR REPLICATION Several studies indicate that HPV hijacks the constitutively active ATR DDR for viral ...productive replication of HPV31 upon differentiation ...
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An essential role for dNTP homeostasis following CDK induced replication stress
... replication stress. (A) set2 Δ wee1-50, rad3 Δ wee1-50 or chk1 Δ wee1-50 result in premature entry into mitosis but the proportion of cells with the ‘ cut ’ phenotype in the set2 Δ wee1-50 mutant is ...
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Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency
... active replication forks in the patients’ ...increased replication speed will impact the den- sity of initiation events, with a lower number of active forks ...higher replication speed in cells from ...
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The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response
... used replication stress-inducing chemotherapeutic agents 5-FU, cyclophosphamide and methotrexate (n = 416, Log Rank ...induced replication stress ...
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Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication
... DNA replication has attracted much ...DNA replication through phosphorylation of ...DNA replication stress, since it is a critical factor of pre-RC in cases of depletion of other pre-RC ...
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Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae
... Dietary regimens have proven to delay aging and age-associated diseases in several eukaryotic model organisms but the input of nutritional balance to longevity regulation is still poorly understood. Here, we present data ...
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Karras, Georgios Ioannis (2010): Mechanism and function of RAD6-mediated DNA damage tolerance. Dissertation, LMU München: Fakultät für Biologie
... of replication stress in eukaryotes may not involve a single DNA ...interpret replication stress-induced foci ...stalled replication, although the radius of these foci is large enough ...
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Novel Connections Between DNA Replication, Telomere Homeostasis, and the DNA Damage Response Revealed by a Genome-Wide Screen for TEL1/ATM Interactions in Saccharomyces cerevisiae
... increased replication stress in the tel1-D xxx-D mutants, we show that depletion of dNTP pools through pretreatment with hydroxyurea renders tel1-D cells (but not wild type) MMS-sensitive, demonstrating ...
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DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication
... sensing replication-induced stress, we took advantage of the availability of phosphospecifi c antibodies that recognize the substrate specifi city motif (SQ and TQ) shared by PIKKs (O’Neill et ...to ...
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