reporter mice
Diet-induced obesity increases NF-κB signaling in reporter mice
... in mice-fed HFD Male and female NF-jB reporter mice were separated in two groups, and fed either HFD (4 females and 4 males) or LFD (5 females and 4 males) for 12 ...NF-jB reporter gene ...
8
In vivo multi-modal imaging of experimental autoimmune uveoretinitis in transgenic reporter mice reveals the dynamic nature of inflammatory changes during disease progression
... modified reporter mice in which leukocyte subtypes are endogenously labelled with a fluorescent reporter gene transcript has greatly enhanced our understanding of cellular and immuno- logical ...
12
Apln-CreERT:mT/mG reporter mice as a tool for sprouting angiogenesis study
... mT/mG reporter mice (Jackson strain: ...mT/mG reporter mice with transgenic mice expressing a tamoxifen regulated Apelin promoter driven Cre recombinase for the study of sprouting ...
9
Sphingosine 1 phosphate receptor 1 reporter mice reveal receptor activation sites in vivo
... These mice, known as S1P1 GFP signaling mice, produce a S1P1 fusion protein containing a tran- scription factor linked by a protease cleavage site at the C terminus as well as a β-arrestin/protease fusion ...
12
p16INK4a reporter mice reveal age promoting effects of environmental toxicants
... exposure, mice were further observed without CS up to 1 year of ...CS-exposed mice showed particulate deposits along the epithelial layer of the nasal papilla, whereas no differences were noted in lung ...
6
Alternatives to animal experimentation for hormonal compounds research
... as reporter mice, xenopus, or zebrafish, and models obtained by somatic gene transfer in reporter sys- tems, combined with imaging technologies, may contribute to strongly decreasing the overall ...
8
Emerging biology of sphingosine 1 phosphate: its role in pathogenesis and therapy
... these mice so that a transcription factor is released from activated S1P 1 to turn on a GFP reporter ...these reporter mice, S1P 1 activation was apparent in the developing cardiovascular ...
10
Upon Intranasal Vesicular Stomatitis Virus Infection, Astrocytes in the Olfactory Bulb Are Important Interferon Beta Producers That Protect from Lethal Encephalitis
... porter mice. A detailed analysis of cell type-specific IFN- reporter mice revealed that within the olfactory bulb IFN- was ex- pressed by neuroectodermal cells, primarily by astrocytes and to a ...
8
Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain
... tional-reporter mice that express firefly luciferase under the con- trol of the IFN- promoter in either all or only distinct cell types, we found that astrocytes are the main producers of IFN-  after ...
8
The mouse cortical meninges are the site of immune responses to many different pathogens, and are accessible to intravital imaging
... In reporter mice in which selected cell types express fluorescent proteins, imaging after infection with fluorescent pathogens (lymphocytic choriomeningitis virus, Trypanosoma brucei or Plasmodium berghei) ...
10
Visualizing the Beta Interferon Response in Mice during Infection with Influenza A Viruses Expressing or Lacking Nonstructural Protein 1
... Nkx-Cre mice to generate animals in which IFN-  promoter-controlled luciferase expression is restricted to lung ep- ithelial cells ...LysM-Cre mice to generate reporter mice which express the ...
6
Suppression of lung inflammation in an LPS induced acute lung injury model by the fruit hull of Gleditsia sinensis
... the reporter mice that received ...h. Mice were anesthetized with Zoletil (Virbac) before imaging to immobilize them for the duration of the integration time of photon counting (3 ...min). ...
8
Directed Evolution of an Influenza Reporter Virus To Restore Replication and Virulence and Enhance Noninvasive Bioluminescence Imaging in Mice
... ABSTRACT Reporter viruses provide a powerful tool to study infection, yet incorporat- ing a nonessential gene often results in virus attenuation and genetic ...in mice to restore replication kinetics and ...
17
A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes
... TGM1 is normally expressed in the suprabasal cells of stratifying epithelia such as epidermis, the upper digestive tract, the female lower genital tract and in the endometrial epithelium late in pregnancy [9]. It is also ...
15
Schönfeld, Regine Margarete (2003): Generation of Transgenic Mice to Evaluate Promoter Activity and Specificity of Two Human Endogenous Retrovirus Long Terminal Repeats = Untersuchungen zur Promotor-Aktivität und -Spezifität von zwei Long Terminal Repeats humaner endogener Retroviren in transgenen Mäusen. Dissertation, LMU München: Tierärztliche Fakultät
... The sensitivity of GFP as reporter gene was described in a recent review as “somewhat disappointing” (Tsien, 1998). GFP´s independence from enzymatic substrates is on the one hand particularly useful for ...
120
Borchardt_unc_0153D_16305.pdf
... We first tested the circGFP-CD construct following plasmid transfection in mammalian cells and observed reporter expression via fluorescence microscopy. CircGFP, which is constitutively backspliced for GFP ...
124
Sox10- Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes
... Sox10 is a well-known marker of neural crest stem cells (NCSCs), along with slug, snail, and p75 [35,36]. There have been numerous reports recently of NCSCs surviving in a wide range of tissues through the entire ...
14
Identification of regulatory elements in the CD8 gene locus.
... The second and m inor initiation site was identified to lie 102bp upstream of the aforem entioned ATG codon. The 5' flanking sequences lack a typical TATA box as well as CAAT sequences. It is rich in GC sequences ...
340
Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors
... the reporter gene luciferase ...apoE-deficient mice with preinfusion plasma total cholesterol of 644 +/- 149 mg/dl an cholesterol rich ...of mice infused with ...control mice infused with ...
10
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia
... Tumor necrosis factor (TNF) is a protein hormone implicated in the development of septic shock and other pathologic states. However, complexities inherent in detecting TNF synthesis by individual tissues have left the ...
7