resident memory t cells
Vaccine-generated lung tissue–resident memory T cells provide heterosubtypic protection to influenza infection
... Tissue-resident memory T cells (TRM) are a recently defined, noncirculating subset with the potential for rapid in situ protective responses, although their generation and role in vaccine- ...
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Influenza specific lung resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles
... Trm cells. The high proportion of influenza- specific Trm cells in HLA-B57 individuals could reflect a differ- ence among HLA-A– and HLA-B–restricted epitopes in develop- ing into Trm cells or could ...
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ABC transporters and NR4A1 identify a quiescent subset of tissue resident memory T cells
... human T cells is to provide lifelong immunity against pathogens lasting several decades ...of T cells within an individual is heterogeneous and includes naive T cells that ...
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Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities
... Distinct functional profile and proliferative capacity of efflux(+) TRMs. Differential expression of key genes involved in cell cycle, quiescence, and T cell function suggested distinct proliferative and ...
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A systematic review: the role of resident memory T cells in infectious diseases and their relevance for vaccine development
... Herpes simplex virus causes infections that present with a varying range of symptoms. The primary clinical manifesta- tions of HSV infection are intraepithelial vesicles. There are two antigenically distinct HSV ...
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Resident memory T cells, critical components in tumor immunology
... on T cells residing in tissue microenvironments, where TGF-β is abundant, such as mucosal CD8 + T lymphocytes and, mainly, IEL [53], but it is also expressed on CD4 + and CD8 + regula- tory T ...
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The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis
... suspensions, cells were treated with Fc block (anti-CD32/CD16 in the form of ...binding. Cells were then counted using the trypan blue dye exclusion method, and 1 × 10 [6] cells were subsequently ...
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Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells
... wherein T cells do not migrate to other antigen-bear- ing tissues in spite of shared systemic circulation ...for T RM cells sug- gested the possibility that each of the metastatic lesions may ...
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Early alterations in stem-like/marrow-resident T cells and innate and myeloid cells in preneoplastic gammopathy
... and resident T cells in the MGUS marrow that we observed may be affect- ed by local signals in the tumor ...ing cells in situ may be critical for tissue retention of murine ...
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Memory regulatory T cells reside in human skin
... of cells purified from peripheral tissue in ...other T cell populations in skin ...cutaneous T cell ...tissue-resident cells as a result of a variety of essential functions they play ...
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Mucosal BCG vaccination induces protective lung-resident memory T cell populations against tuberculosis
... of memory T cells has been shown to be essential for protective TB vaccines ...on T helper type 1 (Th1) CD4 ⫹ T cell responses (7, ...weak memory lymphocyte generation, which in ...
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Mucosal BCG Vaccination Induces Protective Lung Resident Memory T Cell Populations against Tuberculosis
... CD8 T cells infiltrating the airways postvaccination, which revealed heteroge- neous expression of transcription factors and effector molecules and confirmed their ability to mount a recall response to an ...
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Intravaginal immunization with HPV vectors induces tissue resident CD8+ T cell responses
... the T cells extracted from the cervicovaginal tissues after the systemic immunization procedures may have largely been retained within the mucosal vasculature or were loosely associated with the ...
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A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool
... OT-I T cells) by FACS sorting on a FACSAria Fusion (BD Biosciences), cells derived from the three mice were mixed 1:1:1 and taken up in PBS supplemented with ...
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Resident memory CD8+ T cells within cancer islands mediate survival in breast cancer patients
... of T cells into and around the tumor parenchyma (cancer islands), while immune-excluded tumors have T cell infiltration only into tumor stroma but not cancer ...lack T cell infiltration ...
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Tissue patrol by resident memory CD8+ T cells in human skin
... approach to healthy human skin samples and demonstrate that human CD8 + skin-resident TRM cells.. 87.[r] ...
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Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia
... 9]. T cell lymphoblastic leukemia/lymphoma has been described in a patient with concurrent invasive thymoma found at autopsy ...CD8+ T‑LGL was confirmed by flow cytometry and clonality by ...CD8+ T ...
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Increased attrition of memory T cells during sepsis requires 2B4
... generate T cell memory before sepsis induction (48, ...anti-CD3–mediated T cell activation and memory T cell generation demonstrat- ed increased immune dysregulation following sepsis ...
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IgE in asthma and atopy: cellular and molecular connections
... resting T cells, appears on their surface after T-cell receptor (TCR) activation by antigen/MHC (Figure ...B cells provides the second signal for the induction of deletional switch ...
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Cytomegalovirus infection and progressive differentiation of effector-memory T cells
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