Resistance mutations
Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer.
... passenger mutations, are randomly ...passenger mutations can provide the substrate for an evolutionary advantage throughout cancer progression, for example, under the selective pressure of a tar- geted ...
16
Predictable Phenotypes of Antibiotic Resistance Mutations
... chromosomal resistance mutations, we studied the phenotypic expression of 13 resistance mutations (Table 1) in 10 different strain backgrounds with differing genetic distances ...13 ...
14
Emergence of HIV 1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana
... drug resistance mutations to NNRTIs seen in this study all work against the susceptibility of HIV to the ARVs recommended for use in ...high-level resistance to NVP and ...NNRTIs resistance ...
9
Knockdown resistance mutations predict DDT resistance and pyrethroid tolerance in the visceral leishmaniasis vector Phlebotomus argentipes
... of resistance mutations in phlebotomine sandflies and adds significantly to the very limited body of knowledge on insecticide resistance mecha- ...with resistance in any previous studies ...
14
Pre treatment minority HIV 1 drug resistance mutations and long term virological outcomes: is prediction possible?
... The study has a number of limitations in particular the absence of resistance data at the time of virological failure. Additional samples taken at the time of routine viral load testing were not always available ...
9
Ciprofloxacin Resistance in Campylobacter jejuniIsolates: Detection of gyrA Resistance Mutations by Mismatch Amplification Mutation Assay PCR and DNA Sequence Analysis
... quinolone resistance mutation at amino acid position 86 due to separate environmental ...for mutations at amino acid positions 86 and ...additional mutations arose in isolate CS50 following ex- ...
5
Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran
... drug resistance similar to another study per- formed in Ethiopia and China (18, ...Drug resistance test was not carried out before the patients initi- ating ART initiation and also measuring adher- ence to ...
9
Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole Genome Sequencing
... nomes due to falling costs (31). Driven by rapid technological advances, the application of whole-genome sequencing (WGS) to type microbial genomes is increasingly used to improve patient care (32–36). WGS is now ...
12
Tryptophan analog resistance mutations in Chlamydomonas reinhardtii.
... The slow growth phenotypes of strains with class I mutations are not rescued by the addition of tryptophan, but the slow growth phenotype of the maa6-1 mutant strain is partially[r] ...
15
Efavirenz-based simplification after successful early lopinavir-boosted-ritonavir-based therapy in HIV-infected children in Burkina Faso and Côte d’Ivoire: the MONOD ANRS 12206 non-inferiority randomised trial
... NNRTI-resistance mutations at ART initiation in children who failed to develop virological suppression, and the emergence of newly acquired mutations at 12-months post-randomisation (compared to ...
16
Mutations in Human Immunodeficiency Virus Type 1 RNase H Primer Grip Enhance 3′-Azido-3′-Deoxythymidine Resistance
... drug resistance mutations that allow HIV-1 to replicate in the presence of antiviral drugs (5, 14, ...analog resistance mutations (TAMs) allows the virus to increase the efficiency of ...
9
Increased Replicative Fitness Can Lead to Decreased Drug Sensitivity of Hepatitis C Virus
... not become dominant upon passage of HCV p45 and HCV p100 in the presence of cyclosporine (see Table S7 at the URL men- tioned above). (ii) Reductions in the infecting MOI did not affect the kinetics of viral production ...
14
Epistatic Interactions Among Herbicide Resistances in Arabidopsis thaliana: The Fitness Cost of Multiresistance
... three resistance loci, was isolated and selfed to produce the 27 expected genotypes numbered and de- scribed in Table ...several mutations other than the ones conferring resistance ( J ander et ...
12
Mutations Located outside the Integrase Gene Can Confer Resistance to HIV 1 Integrase Strand Transfer Inhibitors
... of mutations selected in the IN gene, mostly involving three residues, N155, Q148, and Y143 ...have mutations in the IN gene (12, ...to resistance and efficacy against viruses resistant to RAL and EVG ...
11
PubMedCentral-PMC4912444.pdf
... to resistance due to active site ...to resistance, avoiding such protrusions will minimize the chances of active site mutations that can confer ...DRV resistance; protease needs to extensively ...
20
Effects of Dipeptide Insertions between Codons 69 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Primer Unblocking, Deoxynucleoside Triphosphate Inhibition, and DNA Chain Elongation
... AZT resistance muta- tions confer an increase in removal of most chain terminators and likely confer some resistance to many types of chain ter- minators in HIV-infected individuals, the impact of these mu- ...
7
In Vivo Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae
... Antibiotic resistance mutations can impact bacterial fitness by conferring a fitness cost or benefit in the absence of antibiotic pressure ...that resistance mutations in gyrA and the mtrR gene ...
18
HIV AIDS Clinical Care - Testing and Assessment
... the mutations that confer resistance to that drug may decrease below the threshold of detection by the resistance assay, so the resistance test may not reveal certain resistance ...
64
Systematic Molecular Characterization of Multidrug Resistant Mycobacterium tuberculosis Complex Isolates from Spain
... different mutations confer- ring resistance, were transmitted before the acquisition of drug resis- ...rpoB mutations (lanes 1 through 5, wild-type sequence of the gene; lane 6, Asp516Gly mutant; ...
8
Chromosomal and plasmid mediated fluoroquinolone resistance in human Salmonella enterica infection in Ghana
... of resistance to fluoroquinolones in ...chromosomal mutations and plasmid-mediated resistance as possible mechanisms of fluoroquinolone resistance from clinical isolates in ...and/or ...
10