resistant cells
Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells in a cell line model
... between resistant and sensitive ...when resistant cells are more fit compared to sensitive cells when drug pressure is on, while when no treatment is present sensitive cells are more ...
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Lonidamine induces apoptosis in drug resistant cells independently of the p53 gene
... in resistant cells, we investi- gated whether LND could also activate the apoptotic program in parental-sensitive ...B) cells in spite of longer time ...LND-treated cells both in MCF-7 WT and ...
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Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
... cisplatin-resistant cells, including glycolysis, glutaminolysis, and metabolic pathways involved in redox ...Cisplatin-resistant cells exhibited increased glucose uptake, overexpression of the ...
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Whole Genome Sequencing of Invasion Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion
... pgsA745 cells differs. Bacterial invasion of cells contributes to penetration of host barriers, a hallmark of pathogenicity, and provides an intracellular niche for bacterial survival and ...CHO-K1 ...
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BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance
... cell lines (Figure 4). The PI3K/mTOR pathway was not comparably inactivated by imatinib, as assessed by RPS6 phosphorylation (Figure 2 Figure 4). These results imply that TKI-resistance is caused by constitutive ...
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EXPERIMENTAL BASIS FOR PREDICTION OF THERAPEUTIC EFFICACY OF STREPTOMYCIN IN INFECTIONS CAUSED BY GRAM NEGATIVE BACILLI
... Correlation with Therapeutic Efficacy of Streptomycin: The relationship of these 2 factors, mutation frequency of resistant cells and speed of lethal action on sensitive cells, to therap[r] ...
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MAMMALIAN CELL GENETICS I. SELECTION AND CHARACTERIZATION OF MUTATIONS AUXOTROPHIC FOR L-GLUTAMINE OR RESISTANT TO 8-AZAGUANINE IN CHINESE HAMSTER CELLS IN VITRO
... The partial revertants were interpreted as representing single-step, isoallelic mutations.-By plating the glutamine-requiring cells and azaguanine-resistant cells together [r] ...
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Citral induced apoptosis in MDA MB 231 spheroid cells
... drug- resistant human breast cancer spheroids by decreasing the ALDH1 population and downregulating Wnt/beta- catenin self-renewal pathway ...drug resistant breast cancer cells has not yet been ...
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Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide
... castration resistant prostate ...DuCaP cells which overexpress wild-type AR, as well as a cell which has been adapted to long term androgen ablation (LNCaP Abl) and harbors the AR T878A ...controls, ...
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<p>MiR-145 Regulates the Chemoresistance of Hepatic Carcinoma Cells Against 5-Fluorouracil by Targeting Toll-Like Receptor 4</p>
... of cells in vitro experiments, and can target ROCK1 to further inhibit the metastasis and progression of ...HCC cells is signi fi cantly down-regulated, and up-regulation of miR-145 can degrade the growth of ...
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P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors
... cancer cells [1, ...Chemoresistant cells have a slightly alkaline pH i that contributes to the maintenance of their drug-resistant phenotype ...doxorubicin-resistant cells analyzed ...
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Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia
... leukemic cells by bone marrow stromal cells (BMSC) as a putative mechanism of drug ...multidrug resistant phenotype in ALL ...ALL cells. In response to this oxidative stress, drug ...
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FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells
... The MAPK signaling and PI3K/AKT signaling are two canonical pathways of RTK signal transduction, functioning in a variety of cellular processes [1,45]. Transcriptomics and proteomics profiles on TNBC samples indicate ...
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5-Fluorouracil Chemotherapy of Gastric Cancer Generates Residual Cells with Properties of Cancer Stem Cells
... patient-derived cells to imatinib resulted in the enrichment of a qui- escent CD34+ population [24]; similar results were observed in an independent study by Jorgensen et ...CML cells were sensitized to ...
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GSK1838705A, an insulin-like growth factor-1 receptor/insulin receptor inhibitor, induces apoptosis and reduces viability of docetaxel-resistant prostate cancer cells both in vitro and in vivo
... Abstract: Prostate cancer is the leading malignancy and the second most common cause of cancer-related death in men. Despite high cure rates with surgery and/or radiation, 30%–40% of patients eventually develop advanced ...
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Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells
... A375 cells with homozy- gous BRAF V600E and IGR37 and 501Mel cells heterozy- gous for BRAF ...Matching cells resistant to these 2 BRAF inhibitors had previously been generated and ...
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On a Mathematical Model of HAART
... become resistant to the drug before the drug is able to eliminate ...drug resistant viruses which are developing rapidly, most notably in the developed countries, where the ARV treatment is relatively more ...
5
Human breast cancer cell lines contain stem like cells that self renew, give rise to phenotypically diverse progeny and survive chemotherapy
... In order to overcome problems associated with procuring and using primary human tissues, continuous breast cancer cell lines have been developed from various sources, including pleural effusions (MDA.MB.231 and MCF7), ...
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Mesenchymal stem cells are resistant to carbon ion radiotherapy
... the cells kept their ability to expand in vitro after exposure to high-dose photon or carbon ion ...the cells’ adherence potential was not significantly altered after both forms of radiation ...those ...
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Glycoprotein D of Bovine Herpesvirus 5 (BoHV-5) Confers an Extended Host Range to BoHV-1 but Does Not Contribute to Invasion of the Brain
... 1gD5 did not group with BoHV-5 and BoHV-5gD1 but rather grouped with the viruses with BoHV-1 backbones. Only BoHV-5 viruses, regardless of their gD types, were able to invade and replicate in the brain. This observation ...
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