retinal pigmented epithelial cells
The loss of gap junctional cell to cell communication is coupled with dedifferentiation of retinal pigmented epithelial cells in the course of transdifferentiation into the lens
... Inl J Oe\' Riol 38 357 364 (1994) 357 The loss of gap junctional cell to cell communication is coupled with dedifferentiation of retinal pigmented epithelial cells in the course of transdifferentiatio[.] ...
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Blue-light filtering alters angiogenic signaling in human retinal pigmented epithelial cells culture model
... RPE cells are well documented in vitro and in vivo [39 – ...RPE cells from light-induced damage and apoptosis in RPE cell cultures [10, 11, ...RPE cells under normoxia, hyp- oxia, and ...
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Effects of Hypoxia and Iron Chelation on the Metabolism of the Amyloid Precursor Protein in Retinal Pigmented Epithelial Cells.
... HEK293T cells, primary neuronal cultures, and brain endothelial cells [47, 94, 95]. This ability to stabilize ferroportin was localized to the E2 domain on the soluble form of APP, but it was now shown that ...
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Artemisinin Protects Human Retinal Pigmented Epithelial Cells Against Hydrogen Peroxide-induced Oxidative Damage by Enhancing the Activation of AMP-active Protein Kinase
... modulation of AMPK. We have previously showed the regulation of ERK/CREB by artemisinin treatment. It was reported that AMPK phosphorylate CREB links our previous finding about ERK/CREB with our present observation about ...
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Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration
... P5 cells (one-way ANOVA P value ...P5 cells, and the products of these genes promote the activity of TGFB1 and ...P5 cells and as such it is a prime candidate for participating in the prevention of ...
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Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease
... stem cells (ESCs) are considered to be the main source for regenerative ...iPSC cells bypass ethical issues and immunological challenges when compared to ESCs [10, ...into retinal pigment epithelium ...
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Zika virus infection of cellular components of the blood-retinal barriers: implications for viral associated congenital ocular disease
... human retinal microvascular endothelial cells, retinal pericytes, and Müller cells as well as retinal pigmented epithelial cells of the OBRB to the PRVABC56 strain ...
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In Vitro Differentiation of Human Bone Marrow Stem Cells into Retinal Pigment Epithelium
... of retinal pigment epithelial (RPE) cells are prominent features of subtypes of retinitis pigmentosa (RP) which is a cause of visual ...Stem cells are self-renewing cells capable of ...
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A unique aged human retinal pigmented epithelial cell line useful for studying lens differentiation in vitro
... untreated cells do not seem to synthesize ...H80HrPE-6 cells proceeded to differentiate, but not in the sma fashion. For cells in agar it took nearly 20 days to achieve lentoid-like appearance while ...
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Original Article Effect of bradykinin on cultured retinal pigment epithelial cells
... rhegmatogenous retinal detachment or after major ocular trauma and its surgical ...with retinal detachment repair is the primary treatment for ...The retinal pigment epi- thelium (RPE) is a highly ...
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Reprogramming of the chick retinal pigmented epithelium after retinal injury
... of cells entering the cell cycle have been observed 24 to 72 h post lesion (for reviews see ...mented epithelial cells from the dorsal iris that are respon- sible for replacing the missing lens ...
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Enhanced generation of retinal progenitor cells from human retinal pigment epithelial cells induced by amniotic fluid
... induce retinal progenitor genes and thus convert an RPE culture into an invaluable source of retinal progenitor ...RPE cells of several of these growth factors, including TGF- β , complement C3, ...
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NLRP3 Inflammasome and Pathobiology in AMD
... understood, a number of genetic and environmental risk factors have been associated with the disease. A recent meta-analysis of genome-wide association studies identified 19 genetic loci associated with increased ...
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In vitro differentiation of cGMP-grade retinal pigmented epithelium from human embryonic stem cells
... these cells by measuring their ability to undergo ...differentiated cells than by the control samples ...stem cells (hESCs) cultured at the Cell and Molecular Therapy ...
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Flammer Syndrome, A Potential Risk Factor for Central Serous Chorioretinopathy?
... of CSCR. Choroidal blood-flow changes can be induced through the production of free radicals, inflammatory cells, and nitric oxide. Long-standing choroidal changes and vein congestion together with the extensive ...
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Transcriptional Reactivation of OTX2, RX1 and SIX3 during Reprogramming Contributes to the Generation of RPE Cells from Human iPSCs
... RPE-like cells can be observed ...RPE-like cells de- veloped pigmented areas at week 8 after initiation of ...cultured cells expressed neural retinal progenitor marker (PAX6) at week 4 ...
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Ion channels of cultured human retinal pigment epithelial cells
... RPE cells in culture are initially undifferentiated and seem to require a precisely defined environment to redifferentiate into cells which resemble those in vivo and display some degree of ...chick ...
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Functional Genetic Analysis of Rhesus Cytomegalovirus: Rh01 Is an Epithelial Cell Tropism Factor
... the very low yields of particles. We have, however, noted a difference in wild-type versus Rhsub01 virus stocks produced in telo-RFs. When cells are infected with the mutant, they con- tain much more pRh112 at 1.5 ...
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Original Article Plasticity of adult human retinal pigment epithelial cells
... RPE cells dedifferenti- ated in vitro, compared with RPE ...treated cells were comparable with the levels in RPE ...RPE cells in vitro both in the presence and absence of Wnt7a ...some cells ...
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Optimization of an in vitro bilayer model for studying the functional interplay between human primary retinal pigment epithelial and choroidal endothelial cells isolated from donor eyes
... hCEC cells would exhibit donor-to-donor ...RPE cells could be used. Also, while we cultured cells upto 11 days, extended growth period is recommended for high polarity, which needs to be further ...
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