Retinal progenitor
Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
... Models of Ccnd1 function in the retina. (A) General model of Ccnd1-dependence in retinal progenitor cells (RPCs). Most, if not all RPCs express CCND1. At least one division before cell cycle exit, RPCs ...
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VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation
... influence progenitor cell fate choices. The process by which uncommitted progenitor cells interpret and integrate signals is not well ...on progenitor cells to influence cell proliferation and ...
10
Characterizing and influencing differentiation of Retinal Progenitor Cells
... by retinal degeneration we need to be able to regenerate these cells in order to restore ...of retinal progenitor cells at the bottom of a 24 well plate and culture retinal explants in a ...
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Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes
... of retinal ganglion cells in various vertebrate species (Liu et ...of retinal ganglion cells (Austin et ...of retinal progenitor cells, and that of the dominant-negative form of the ligand ...
12
Dual requirement for Pax6 in retinal progenitor cells
... The retinal neuroepithelium emerges from the distal tip of the optic vesicles (OVs), established as lateral protrusions from the ventral ...from retinal progenitor cells (RPCs) in the central OC, and ...
11
The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells
... In this report, we isolated and maintained adult mouse retinal progenitor cells (RPCs) under a chemically de- fined culture. The self-renewing mNRPCs could differ- entiate into rod photoreceptor-like cells ...
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Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically induced rotenone mouse model of Leber hereditary optic neuropathy
... embryonic retinal cells do not integrate into the ganglion cell layer (GCL), unlike similarly obtained photoreceptor precursors, which can integrate retinally and act to preserve vision in models of ...cultured ...
7
The early retinal progenitor expressed gene Sox11 regulates the timing of the differentiation of retinal cells
... early retinal progenitor cells and that Sox4 expression began around birth, when expression of Sox11 ...in retinal development, we perturbed their expression patterns in retinal explant ...in ...
11
Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration
... Degenerative retinal diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP), are the leading causes of blindness in the developed world, and their common pathology includes the ...
19
Original Article Comparison of human retinal progenitor cells cultured in media with or without serum: in vitro and in vivo characteristics and retinal transplantation
... Abstract: Retinal progenitor cells (RPCs) have a potential role in the treatment of retinal degenerative ...and retinal transplantation of RPCs cultured in media with or without ...serum. ...
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Defining retinal progenitor cell competence in Xenopus laevis by clonal analysis
... individual retinal progenitor cells (RPCs) generate ...of retinal cells is formed in 2 ...All retinal cell types were generated throughout nearly the entire retinogenesis ...same ...
9
Enhanced generation of retinal progenitor cells from human retinal pigment epithelial cells induced by amniotic fluid
... cells, retinal derived progenitor cells may be a more efficient treatment for vis- ual impairment ...of retinal pigment epithelium (RPE) transplantation in animal models [21-23] and human trials ...
10
Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells
... retina, retinal pigment epithelium (RPE), and optic ...specified retinal progenitor cells (RPCs) undergoes extensive proliferative expansion to generate sufficient cell numbers for the formation of a ...
22
Original Article Transplanted retinal progenitor cells exhibit long-term survival and function in a murine model of laser photocoagulation
... sub retinal space receiving neonatal retinal allografts can induces immune deviation ...transplanted retinal sheets can sur- vive in the sub retinal space for several months, although older ...
6
Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions
... rat retinal progenitor cell (RPC) undergoing a P/D division (t20:30) and a terminal D/D division (t58:11) giving rise to a three-cell clone composed of an amacrine (Am), a bipolar (Bi) and a rod ...
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Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients
... Given the crucial role played by photoreceptors in vis- ual perception, current transplantation strategies aim to replace degenerating photoreceptors as a way of restor- ing some functional vision. The use of ...
12
Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development
... To substantiate these results, we performed clonal analysis with a replication-incompetent avian retrovirus [RIS(B)]. We infected chick embryos at the optic vesicle stage with low-titer RIS(B) viruses that contained ...
7
Retinal horizontal cells: challenging paradigms of neural development and cancer biology
... common retinal progenitor cell population (Turner et ...these retinal progenitor cells translocate to the future outer limiting membrane (OLM) of the developing retina (the ventricular ...
11
A directional Wnt/β catenin Sox2 proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina
... promotes retinal progenitor proliferation, whereas Sox2 activation does not If both Wnt/ β -catenin activation and Sox2 overexpression prevent neuronal differentiation through the same mechanism, why is it ...
11
Progress of stem/progenitor cell based therapy for retinal degeneration
... critical retinal progenitor-related marker) and co-expression of extensive mature retinal specific markers including rho- dopsin, protein kinase C-α, cellular retinaldehyde binding protein and ...
13